F6TXY0 · F6TXY0_MONDO

Function

Catalytic activity

  • S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.
    EC:2.3.2.23 (UniProtKB | ENZYME | Rhea)
  • S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E1 ubiquitin-activating enzyme]-L-cysteine + N6-monoubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.24 (UniProtKB | ENZYME | Rhea)

Features

Showing features for active site.

118020406080100120140160180
TypeIDPosition(s)Description
Active site115Glycyl thioester intermediate

GO annotations

AspectTerm
Cellular Componentanaphase-promoting complex
Cellular Componentcytosol
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionubiquitin conjugating enzyme activity
Molecular Functionubiquitin-like protein ligase binding
Biological Processanaphase-promoting complex-dependent catabolic process
Biological Processexit from mitosis
Biological Processfree ubiquitin chain polymerization
Biological Processpositive regulation of exit from mitosis
Biological Processpositive regulation of mitotic metaphase/anaphase transition
Biological Processprotein K11-linked ubiquitination
Biological Processprotein K48-linked ubiquitination
Biological Processprotein polyubiquitination
Biological Processregulation of mitotic metaphase/anaphase transition

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ubiquitin-conjugating enzyme E2 C
  • EC number
  • Alternative names
    • (E3-independent) E2 ubiquitin-conjugating enzyme C
    • E2 ubiquitin-conjugating enzyme C
    • Ubiquitin carrier protein C
    • Ubiquitin-protein ligase C

Gene names

    • Name
      UBE2C

Organism names

Accessions

  • Primary accession
    F6TXY0

Proteomes

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-32Disordered
Domain31-176UBC core

Sequence similarities

Belongs to the ubiquitin-conjugating enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    180
  • Mass (Da)
    19,629
  • Last updated
    2011-07-27 v1
  • Checksum
    F8D61E41E7110E64
MASQNRDPAAASAAAASRKGAEPGAGAARGSVGKRLQQELMTLMMSGDKGISAFPESDNLFKWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFVTPCYHPNVDTQGNICLDILKDKWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWTNPTAFKKYLLETYMKQVTSQEP

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F8GPJ2A0A5F8GPJ2_MONDOUBE2C151
A0A5F8HKQ0A0A5F8HKQ0_MONDOUBE2C80
A0A5F8HEB3A0A5F8HEB3_MONDOUBE2C51

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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