F6TVP2 · F6TVP2_MOUSE
- ProteinDeoxynucleoside triphosphate triphosphohydrolase SAMHD1
- GeneSamhd1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids631 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
Catalytic activity
- a 2'-deoxyribonucleoside 5'-triphosphate + H2O = a 2'-deoxyribonucleoside + triphosphate + H+This reaction proceeds in the forward direction.
- dATP + H2O = 2'-deoxyadenosine + triphosphate + H+This reaction proceeds in the forward direction.
- dCTP + H2O = 2'-deoxycytidine + triphosphate + H+This reaction proceeds in the forward direction.
- dGTP + H2O = 2'-deoxyguanosine + triphosphate + H+This reaction proceeds in the forward direction.
- dTTP + H2O = thymidine + triphosphate + H+This reaction proceeds in the forward direction.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromosome | |
Molecular Function | catalytic activity | |
Molecular Function | GTP binding | |
Molecular Function | metal ion binding | |
Biological Process | defense response to virus | |
Biological Process | DNA repair | |
Biological Process | DNA replication |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameDeoxynucleoside triphosphate triphosphohydrolase SAMHD1
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionF6TVP2
Proteomes
Organism-specific databases
Subcellular Location
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-51 | Disordered | ||||
Sequence: XTSQPRVSEVAMQSAPLEQPAKRPRCDGSPRTPPSTPPATANLSADDDFQN | ||||||
Domain | 57-122 | SAM | ||||
Sequence: WEPEDVCSFLENRGFREKKVLDIFRDNKIAGSFLPFLDEDRLEDLGVSSLEERKKMIECIQQLSQS | ||||||
Domain | 176-328 | HD | ||||
Sequence: RFEHSLGVGYLAGCLVRALAEKQPELQISERDILCVQIAGLCHDLGHGPFSHMFDGRFIPRARPEKKWKHEQGSIEMFEHLVNSNELKLVMKNYGLVPEEDITFIKEQIMGPPITPVKDSLWPYKGRPATKSFLYEIVSNKRNGIDVDKWDYF | ||||||
Region | 606-631 | Disordered | ||||
Sequence: CGAGEMAEDPDSIPSTQQPHAAHNQL | ||||||
Compositional bias | 616-631 | Polar residues | ||||
Sequence: DSIPSTQQPHAAHNQL |
Sequence similarities
Belongs to the SAMHD1 family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length631
- Mass (Da)72,858
- Last updated2011-07-27 v1
- ChecksumE3B40F6C4DDB9639
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for non-terminal residue, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: X | ||||||
Compositional bias | 616-631 | Polar residues | ||||
Sequence: DSIPSTQQPHAAHNQL |
Keywords
- Technical term