F6S3S1 · F6S3S1_MONDO

Function

function

Produces nitric oxide (NO) which is a messenger molecule with diverse functions.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin (UniProtKB | Rhea| CHEBI:59560 )

FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD.
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN.
heme b (UniProtKB | Rhea| CHEBI:60344 )

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site174Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue

GO annotations

AspectTerm
Cellular Componentcaveola
Cellular Componentcytosol
Cellular ComponentGolgi apparatus
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular Functionactin monomer binding
Molecular Functionarginine binding
Molecular Functioncalmodulin binding
Molecular Functionflavin adenine dinucleotide binding
Molecular FunctionFMN binding
Molecular Functionheme binding
Molecular Functionmetal ion binding
Molecular FunctionNADP binding
Molecular Functionnitric-oxide synthase activity
Molecular Functiontetrahydrobiopterin binding
Biological Processarginine catabolic process
Biological Processendothelial cell migration
Biological Processnegative regulation of blood pressure
Biological Processnitric oxide biosynthetic process
Biological Processnitric oxide mediated signal transduction
Biological Processpositive regulation of angiogenesis
Biological Processpositive regulation of blood vessel endothelial cell migration
Biological Processpositive regulation of guanylate cyclase activity
Biological Processregulation of systemic arterial blood pressure by endothelin
Biological Processremoval of superoxide radicals
Biological Processresponse to fluid shear stress
Biological Processresponse to hormone
Biological Processresponse to lipopolysaccharide

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Nitric oxide synthase
  • EC number

Gene names

    • Name
      NOS3

Organism names

Accessions

  • Primary accession
    F6S3S1

Proteomes

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region26-59Disordered
Compositional bias40-54Pro residues
Region78-111Disordered
Domain510-693Flavodoxin-like
Domain746-992FAD-binding FR-type

Sequence similarities

Belongs to the NOS family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,193
  • Mass (Da)
    131,808
  • Last updated
    2013-01-09 v2
  • Checksum
    28C0C6999C6D8305
MGNLKSVGQEPGPPCGLGLGLGLGLCSKQSGTPGPENGGPPVADISPPVARPPEGPKFSRIKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVSPRQLQSRPTEGPPSPGQLLIQARDFINQYYSSIKRSGSPAHGQRLGEVEAEVAATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCSSAQEMFTYICNHIKYATNKGNLRSAITVFPQRSPGKGDFRIWNSQLIRYAGYRQQDGSVLGDPANVEITELCIQHGWTPGDGRFDVLPLLLQASDEPPELFPLPPELVLEVPLQHPTLEWFESLGLRWYALPAVSNMLLEIGGLEFPAVPFSGWYMSSEIGMRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINLAVLHSYQLAKVTIVDHHAATASFMKHLENEQRARGGCPADWVWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGTTTKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGERFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSDTLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFQGWAQAAFRASCETFCVGDDAKAAARDIFSPKRSWKRQRYRLSAQPEGLQLLPGLIHVHRRKMFPATVLSVENLQSSKSTRATILVRLATGGQEGLQYQPGDHIGICPPNRPGLVEALLSRVEDPPLPSEPIAVEQLEKGSPGGPPPGWVRDPRLPSCTLQQALTFFLDITSPPGPQLLRLLSTLAEEASEQQELEALSKDARRYEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVLAYRTQDGLGPLHYGVCSSWLSQLKAGDIVPCFIRGAPSFRLPSDPNVPCILVGPGTGIAPFRGFWQERLHDIENKGLHPAPMTLVFGCRCSQLDHLYREEVQDAQHRGVFGRVLTAFSRELDSPKTYVQDILRTELASEVHRVLCREGGHMFVCGDVTMATSVLQTVQRILATEGGMELSEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTNRIRTQSFSLQERQARSAVPWALSEPTPETPES

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias40-54Pro residues

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

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