F6S3S1 · F6S3S1_MONDO
- ProteinNitric oxide synthase
- GeneNOS3
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1193 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Produces nitric oxide (NO) which is a messenger molecule with diverse functions.
Catalytic activity
- 2 L-arginine + 3 NADPH + 4 O2 + H+ = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2OThis reaction proceeds in the forward direction.
2 CHEBI:32682 + 3 CHEBI:57783 + 4 CHEBI:15379 + CHEBI:15378 = 2 CHEBI:57743 + 2 CHEBI:16480 + 3 CHEBI:58349 + 4 CHEBI:15377
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 FAD.
Note: Binds 1 FMN.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 174 | Fe (UniProtKB | ChEBI) of heme b (UniProtKB | ChEBI); axial binding residue | |||
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNitric oxide synthase
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Metatheria > Didelphimorphia > Didelphidae > Monodelphis
Accessions
- Primary accessionF6S3S1
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 26-59 | Disordered | |||
Compositional bias | 40-54 | Pro residues | |||
Region | 78-111 | Disordered | |||
Domain | 510-693 | Flavodoxin-like | |||
Domain | 746-992 | FAD-binding FR-type | |||
Sequence similarities
Belongs to the NOS family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,193
- Mass (Da)131,808
- Last updated2013-01-09 v2
- Checksum28C0C6999C6D8305
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 40-54 | Pro residues | |||
Keywords
- Technical term