F6RQL9 · MTAP_MACMU

Function

function

Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.

Catalytic activity

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.

Features

Showing features for binding site, site.

Type
IDPosition(s)Description
Binding site18phosphate (UniProtKB | ChEBI)
Binding site60-61phosphate (UniProtKB | ChEBI)
Binding site93-94phosphate (UniProtKB | ChEBI)
Site178Important for substrate specificity
Binding site196substrate
Binding site197phosphate (UniProtKB | ChEBI)
Binding site220-222substrate
Site233Important for substrate specificity

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentnucleoplasm
Molecular FunctionS-methyl-5-thioadenosine phosphorylase activity
Biological ProcessL-methionine salvage from methylthioadenosine
Biological Processmethylation
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-methyl-5'-thioadenosine phosphorylase
  • EC number
  • Alternative names
    • 5'-methylthioadenosine phosphorylase
      (MTA phosphorylase
      ; MTAP
      ; MTAPase
      )

Gene names

    • Name
      MTAP

Organism names

  • Taxonomic identifier
  • Strain
    • 17573
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca

Accessions

  • Primary accession
    F6RQL9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00004151131-283S-methyl-5'-thioadenosine phosphorylase
Modified residue51N6-acetyllysine

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    283
  • Mass (Da)
    31,236
  • Last updated
    2011-07-27 v1
  • MD5 Checksum
    72821AE23BC4114E21E7F392E7D65658
MASGTTTTAVKIGIIGGTGLDDPEILEGRTEKYVDTPFGKPSDALILGKIKNVDCVLLARHGRQHTIMPSKVNYQANIWALKEEGCTHVIVTTACGSLREEIQPGDIVIIDQFIDRTTMRPQSFYDGSHSCARGVCHIPMAEPFCPKTREVLIETAKKLGLRCHSKGTMVTIEGPRFSSRAESFMFRTWGADVINMTTVPEVVLAKEAGICYASIAMATDYDCWKEHEEAVSVDRVLKTLKENANKAKSLLLTTIPQIGSTEWSETLHNLKNMAQFSVLLPRH

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1I7Q457A0A1I7Q457_MACMUMTAP273

Keywords

Sequence databases

Genome annotation databases

Similar Proteins

Disclaimer

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