F6R7W3 · F6R7W3_MONDO

Function

function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Fe2+ (UniProtKB | Rhea| CHEBI:29033 )

Pathway

Cofactor biosynthesis; NAD+ biosynthesis; quinolinate from L-kynurenine: step 3/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site128O2 (UniProtKB | ChEBI)
Binding site132Fe cation (UniProtKB | ChEBI); catalytic
Binding site138Fe cation (UniProtKB | ChEBI); catalytic
Binding site138substrate
Binding site176Fe cation (UniProtKB | ChEBI); catalytic
Binding site180substrate
Binding site190substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentcytosol
Molecular Function3-hydroxyanthranilate 3,4-dioxygenase activity
Molecular Functionferrous iron binding
Biological Process'de novo' NAD biosynthetic process from tryptophan
Biological Processanthranilate metabolic process
Biological Processneuron cellular homeostasis
Biological Processquinolinate biosynthetic process
Biological Processquinolinate metabolic process
Biological Processresponse to cadmium ion
Biological Processresponse to zinc ion
Biological Processtryptophan catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    3-hydroxyanthranilate 3,4-dioxygenase
  • EC number
  • Alternative names
    • 3-hydroxyanthranilate oxygenase
      (3-HAO
      )
    • 3-hydroxyanthranilic acid dioxygenase
      (HAD
      )

Gene names

    • Name
      HAAO

Organism names

Accessions

  • Primary accession
    F6R7W3

Proteomes

Subcellular Location

Keywords

Expression

Gene expression databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-299Domain A (catalytic)
Region299-371Domain B

Sequence similarities

Belongs to the 3-HAO family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    371
  • Mass (Da)
    41,377
  • Last updated
    2019-12-11 v2
  • Checksum
    C2EFC8456D1896F1
MTADLRNSDCQLVTVGHQSFLVMGVLLIPGVPDVVEELVGGKRDRDGMDIFSPQSRDQGKQLAIEAHPERGEKDFMGGKSQPVGNGASVASSHIGGLHSVVFKDLISLLDFWHQSQLKVMFVGGPNQRKDYHIEEGEEIFYQLEGHMVLGILEKGQRRDVLIRQGEIFLLPAGIPHSPQRFANTVGLVVERERLKTETDGLRYYVGDTTNVLFEKWFYCEDLGTQLAPIIQEFFNSEQYKTGKPCPDQLLKEPPFPLSTRTVMEPLSLQGWLDTHRRELKAGSTLSMFGDTYETEVKVCGSGSSKGPKLNVDLWLWQLEGSSVVTIEGQKLHLAPDDSLLVPKGTMYLWERAQDCVALAVTQNPENKKPLG

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F8HG89A0A5F8HG89_MONDOHAAO316

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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