Lineage-specific biology revealed by a finished genome assembly of the mouse.Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L.[...], Ponting C.P.View abstractCited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCPLoS Biol. 7:E1000112-E1000112 (2009)Cited in99+99+
Modernizing reference genome assemblies.Church D.M., Schneider V.A., Graves T., Auger K., Cunningham F., Bouk N., Chen H.C., Agarwala R., McLaren W.M.[...], Hubbard T.Cited forNUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]StrainC57BL/6JCategoriesSequencesSourceUniProtKB unreviewed (TrEMBL)PubMedEurope PMCPLoS Biol 9:e1001091-e1001091 (2011)Cited in99+
No title available.EnsemblCited forIDENTIFICATIONStrainC57BL/6JSourceUniProtKB unreviewed (TrEMBL)Submission Submitted to UniProtKB (JUN-2024)Cited in99+
Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase.Yamauchi T., Kaburagi Y., Ueki K., Tsuji Y., Stark G.R., Kerr I.M., Tsushima T., Akanuma Y., Komuro I.[...], Kadowaki T.View abstractCategoriesPTM / ProcessingSourceMGI: 1098772PubMedEurope PMCJ Biol Chem 273:15719-15726 (1998)Mapped to29
An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme.Janssen J.W.G., Schleithhoff L., Bartram C.R., Schulz A.S.View abstractCategoriesSequencesSourceMGI: 1098772PubMedEurope PMCOncogene 16:1767-1772 (1998)Cited in2Mapped to3
The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.Laviola L., Giorgino F., Chow J.C., Baquero J.A., Hansen H., Ooi J., Zhu J., Riedel H., Smith R.J.View abstractCategoriesSequences, InteractionSourceMGI: 1098772PubMedEurope PMCJ. Clin. Invest. 99:830-837 (1997)Cited in1Mapped to45
Mouse p170 is a novel phosphatidylinositol 3-kinase containing a C2 domain.Virbasius J.V., Guilherme A., Czech M.P.View abstractCategoriesSequencesSourceMGI: 1098772PubMedEurope PMCJ. Biol. Chem. 271:13304-13307 (1996)Cited in1Mapped to14
The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase.Pons S., Asano T., Glasheen E., Miralpeix M., Zhang Y., Fisher T.L., Myers M.G. Jr., Sun X.J., White M.F.View abstractCategoriesSequencesSourceMGI: 1098772PubMedEurope PMCMol. Cell. Biol. 15:4453-4465 (1995)Cited in1Mapped to18
Genetic determinants of micronucleus formation in vivo.Adams D.J., Barlas B., McIntyre R.E., Salguero I., van der Weyden L., Barros A., Vicente J.R., Karimpour N., Haider A.[...], White J.K.View abstractSourceMGI: 1098772PubMedEurope PMCNature 627:130-136 (2024)Mapped to99+
Identification and analysis of key circRNAs in the mouse embryonic ovary provides insight into primordial follicle development.Wang X., Zhang Y., Yu J., Ma Y., Xu Y., Shi J., Qi Z., Liu X.View abstractSourceMGI: 1098772PubMedEurope PMCBMC Genomics 25:139-139 (2024)Mapped to84
Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling.Wang Q., Tao C., Hannan A., Yoon S., Min X., Peregrin J., Qu X., Li H., Yu H.[...], Zhang X.View abstractCategoriesFunctionSourceMGI: 1098772PubMedEurope PMCSci Adv 7:eabf1068-eabf1068 (2021)Mapped to99+
Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality.Mendenhall M.A., Liu S., Portley M.K., O'Mard D., Fattah R., Szabo R., Bugge T.H., Khillan J.S., Leppla S.H., Moayeri M.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1098772PubMedEurope PMCNat Microbiol 5:1464-1471 (2020)Mapped to13
PIK3R2/Pik3r2 Activating Mutations Result in Brain Overgrowth and EEG Changes.Shi X., Lim Y., Myers A.K., Stallings B.L., Mccoy A., Zeiger J., Scheck J., Cho G., Marsh E.D.[...], Golden J.A.View abstractCategoriesFunctionSourceMGI: 1098772PubMedEurope PMCAnn Neurol 88:1077-1094 (2020)Mapped to73
IL-7R-Dependent Phosphatidylinositol 3-Kinase Competes with the STAT5 Signal to Modulate T Cell Development and Homeostasis.Cui G., Shimba A., Ma G., Takahara K., Tani-Ichi S., Zhu Y., Asahi T., Abe A., Miyachi H.[...], Ikuta K.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1098772PubMedEurope PMCJ Immunol 204:844-857 (2020)Mapped to21
Mouse screen reveals multiple new genes underlying mouse and human hearing loss.Ingham N.J., Pearson S.A., Vancollie V.E., Rook V., Lewis M.A., Chen J., Buniello A., Martelletti E., Preite L.[...], Steel K.P.View abstractCategoriesFunctionSourceMGI: 1098772PubMedEurope PMCPLoS Biol. 17:E3000194-E3000194 (2019)Cited in4Mapped to99+
Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.Mathew G., Hannan A., Hertzler-Schaefer K., Wang F., Feng G.S., Zhong J., Zhao J.J., Downward J., Zhang X.View abstractCategoriesFunctionSourceMGI: 1098772PubMedEurope PMCProc Natl Acad Sci U S A 113:13156-13161 (2016)Mapped to75
PI3K p85 beta regulatory subunit deficiency does not affect NK cell differentiation and increases NKG2D-mediated activation.Rojas J.M., Spada R., Sanz-Ortega L., Morillas L., Mejias R., Mulens-Arias V., Perez-Yague S., Barber D.F.View abstractCategoriesFunction, InteractionSourceMGI: 1098772PubMedEurope PMCJ Leukoc Biol 100:1285-1296 (2016)Mapped to5
Defective podocyte insulin signalling through p85-XBP1 promotes ATF6- dependent maladaptive ER-stress response in diabetic nephropathy.Madhusudhan T., Wang H., Dong W., Ghosh S., Bock F., Thangapandi V.R., Ranjan S., Wolter J., Kohli S.[...], Isermann B.View abstractCategoriesFunctionSourceMGI: 1098772PubMedEurope PMCNat Commun 6:6496-6496 (2015)Mapped to45
Phosphoinositide 3-kinase p85beta regulates invadopodium formation.Cariaga-Martinez A.E., Cortes I., Garcia E., Perez-Garcia V., Pajares M.J., Idoate M.A., Redondo-Munoz J., Anton I.M., Carrera A.C.View abstractCategoriesFunctionSourceMGI: 1098772PubMedEurope PMCBiol Open 3:924-936 (2014)Mapped to42
Optogenetic control of PIP3: PIP3 is sufficient to induce the actin-based active part of growth cones and is regulated via endocytosis.Kakumoto T., Nakata T.View abstractCategoriesFunction, Subcellular LocationSourceMGI: 1098772PubMedEurope PMCPLoS One 8:e70861-e70861 (2013)Mapped to29
p38alpha senses environmental stress to control innate immune responses via mechanistic target of rapamycin.Katholnig K., Kaltenecker C.C., Hayakawa H., Rosner M., Lassnig C., Zlabinger G.J., Gaestel M., Muller M., Hengstschlager M.[...], Weichhart T.View abstractCategoriesFunctionSourceMGI: 1098772PubMedEurope PMCJ Immunol 190:1519-1527 (2013)Mapped to50
Acute inhibition of PI3K-PDK1-Akt pathway potentiates insulin secretion through upregulation of newcomer granule fusions in pancreatic beta- cells.Aoyagi K., Ohara-Imaizumi M., Nishiwaki C., Nakamichi Y., Ueki K., Kadowaki T., Nagamatsu S.View abstractCategoriesFunction, Phenotypes & VariantsSourceMGI: 1098772PubMedEurope PMCPLoS One 7:e47381-e47381 (2012)Mapped to12
The miR-126 regulates angiopoietin-1 signaling and vessel maturation by targeting p85beta.Sessa R., Seano G., di Blasio L., Gagliardi P.A., Isella C., Medico E., Cotelli F., Bussolino F., Primo L.View abstractCategoriesFunctionSourceMGI: 1098772PubMedEurope PMCBiochim Biophys Acta 1823:1925-1935 (2012)Mapped to9
Class IA phosphatidylinositol 3-kinase regulates osteoclastic bone resorption through protein kinase B-mediated vesicle transport.Shinohara M., Nakamura M., Masuda H., Hirose J., Kadono Y., Iwasawa M., Nagase Y., Ueki K., Kadowaki T.[...], Takayanagi H.View abstractCategoriesFunctionSourceMGI: 1098772PubMedEurope PMCJ Bone Miner Res 27:2464-2475 (2012)Mapped to16
p85beta phosphoinositide 3-kinase subunit regulates tumor progression.Cortes I., Sanchez-Ruiz J., Zuluaga S., Calvanese V., Marques M., Hernandez C., Rivera T., Kremer L., Gonzalez-Garcia A., Carrera A.C.View abstractCategoriesFunctionSourceMGI: 1098772PubMedEurope PMCProc Natl Acad Sci U S A 109:11318-11323 (2012)Mapped to9