F6Q262 · F6Q262_MACMU

Function

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

112211002003004005006007008009001,0001,1001,200
TypeIDPosition(s)Description
Binding site296Ca2+ 1 (UniProtKB | ChEBI)
Binding site296Ca2+ 2 (UniProtKB | ChEBI)
Binding site384Ca2+ 1 (UniProtKB | ChEBI)
Binding site436Zn2+ (UniProtKB | ChEBI); catalytic
Active site437
Binding site440Zn2+ (UniProtKB | ChEBI); catalytic
Binding site446Zn2+ (UniProtKB | ChEBI); catalytic
Binding site493Ca2+ 1 (UniProtKB | ChEBI)
Binding site496Ca2+ 1 (UniProtKB | ChEBI)
Binding site496Ca2+ 2 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular matrix
Cellular Componentextracellular region
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processextracellular matrix organization
Biological Processeye development
Biological Processnegative regulation of platelet aggregation
Biological Processproteolysis

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Submitted names
    • ADAM metallopeptidase with thrombospondin type 1 motif 18

Gene names

    • Name
      ADAMTS18

Organism names

  • Taxonomic identifier
  • Strain
    • 17573
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Cercopithecidae > Cercopithecinae > Macaca

Accessions

  • Primary accession
    F6Q262

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-16
ChainPRO_500334447317-1221
Disulfide bond369↔420
Disulfide bond395↔402
Disulfide bond414↔493
Disulfide bond453↔477
Disulfide bond521↔546
Disulfide bond532↔553
Disulfide bond541↔572
Disulfide bond566↔577
Disulfide bond601↔638
Disulfide bond605↔643
Disulfide bond616↔628

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

TypeIDPosition(s)Description
Compositional bias216-237Polar residues
Region216-291Disordered
Domain293-498Peptidase M12B
Domain1184-1221PLAC

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,221
  • Mass (Da)
    135,080
  • Last updated
    2016-11-30 v2
  • Checksum
    F8FC3790D808CC55
MECALLLACALPAAGSGPPRGPAGLGRVAKALQLCCLCCASVAAALASDSSSGASGLNDDYVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSSHFIVQVVGKDGASETLKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKVQRYRGYPSSGQNYPGYSPSHIPHASQSQETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKYQERHCNNPKPQYGGKFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVIIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNLPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYAWSIVQSECPVSCGGGYINVKAICLRDQNIQVNSSFCSVRTKPVTEPKICNAFSCPAYWMPGEWSTCSKSCAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPEWSLGPWSQCSKTCGRGVRRRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNNRLQWVASSWSECSATCGLGVRKREIKCSEKGFQGKLITFPERRCRNIKRPNLDLEETCNQRACPAHPVYNVVAGWYSSPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRKI

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5F7ZNN3A0A5F7ZNN3_MACMUADAMTS181198

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias216-237Polar residues

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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