F6PWC8 · F6PWC8_HORSE

  • Protein
    Prostaglandin reductase 1
  • Gene
    PTGR1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

Catalytic activity

  • (5S,12S)-dihydroxy-(6E,10E,12E,14Z)-eicosatetraenoate + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H+
    This reaction proceeds in the forward direction.
  • 13,14-dihydro-15-oxo-PGF2alpha + NADP+ = 15-oxoprostaglandin F2alpha + NADPH + H+
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin E1 + NADP+ = 15-oxoprostaglandin E1 + NADPH + H+
    This reaction proceeds in the backward direction.
  • 13,14-dihydro-15-oxo-prostaglandin F1alpha + NADP+ = 15-oxoprostaglandin F1alpha + NADPH + H+
    This reaction proceeds in the backward direction.
  • 20-hydroxy-leukotriene B4 + NADP+ = 12-oxo-20-hydroxy-leukotriene B4 + NADPH + H+
    This reaction proceeds in the forward direction.
  • 4-hydroxynonanal + NADP+ = (E)-4-hydroxynon-2-enal + NADPH + H+
    This reaction proceeds in the backward direction.
  • 6-trans-leukotriene B4 + NADP+ = 12-oxo-(5S)-hydroxy-(6E,8E,10E,14Z)-eicosatetraenoate + NADPH + H+
    This reaction proceeds in the forward direction.
  • nonan-2-one + NADP+ = (3E)-nonen-2-one + NADPH + H+
    This reaction proceeds in the backward direction.
  • octanal + NADP+ = (2E)-octenal + NADPH + H+
    This reaction proceeds in the backward direction.
  • pentan-2-one + NADP+ = (E)-pent-3-en-2-one + NADPH + H+
    This reaction proceeds in the backward direction.
  • an n-alkanal + NADP+ = an alk-2-enal + NADPH + H+
    This reaction proceeds in the backward direction.
    EC:1.3.1.74 (UniProtKB | ENZYME | Rhea)
  • decanal + NADP+ = (2E)-decenal + NADPH + H+
    This reaction proceeds in the backward direction.
  • dodecanal + NADP+ = (2E)-dodecenal + NADPH + H+
    This reaction proceeds in the backward direction.
  • hexanal + NADP+ = (E)-hex-2-enal + NADPH + H+
    This reaction proceeds in the backward direction.
  • leukotriene B4 + NADP+ = 12-oxo-leukotriene B4 + NADPH + H+
    This reaction proceeds in the forward direction.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function15-oxoprostaglandin 13-oxidase [NAD(P)+] activity
Molecular Function2-alkenal reductase [NAD(P)+] activity
Biological Processprostaglandin metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Prostaglandin reductase 1
  • EC number
  • Alternative names
    • 15-oxoprostaglandin 13-reductase
    • Dithiolethione-inducible gene 1 protein
    • Leukotriene B4 12-hydroxydehydrogenase
    • NAD(P)H-dependent alkenal/one oxidoreductase

Gene names

    • Name
      PTGR1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Thoroughbred
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Perissodactyla > Equidae > Equus

Accessions

  • Primary accession
    F6PWC8

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Monomer or homodimer.

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain15-310Enoyl reductase (ER)

Sequence similarities

Belongs to the NADP-dependent oxidoreductase L4BD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    312
  • Mass (Da)
    33,659
  • Last updated
    2023-09-13 v3
  • Checksum
    047944D30680B472
MVHAKTWILKKHFEGSPTNSNFELKTVELPPLKNGAATKLKEGDVMMGQQVARVVESQNSAFPTGTIVLAHSGWTMHSISDGKALEKLPTGWPDTLPLSLALGTVGMPGLTAYFGLLEICGVKGGETVMVNAAAGAVGSVVGQIAKLKGCKVVGAAGSDEKVAYLKKIGFDVAFNYKKVESLEETLKKASPDGYDCYFDNVGGVFSNTVICQMKKFGRIAICGAISTYNRTGELPPGPPPENMIYQQLRMEGFIVTTWQGEVREKALKDLLKWVLEGKIQYHEHITEGFENMPAAFMGMLKGENLGKAIVKA

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A9L0S2F1A0A9L0S2F1_HORSEPTGR1329
A0A5F5PMB4A0A5F5PMB4_HORSEPTGR1301

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp