F6PUC5 · F6PUC5_MONDO
- ProteinPlasma membrane ascorbate-dependent reductase CYBRD1
- GeneCYBRD1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids284 (go to sequence)
- Protein existencePredicted
- Annotation score4/5
Function
Catalytic activity
- Cu2+(out) + L-ascorbate(in) = Cu+(out) + H+ + monodehydro-L-ascorbate radical(in)This reaction proceeds in the forward direction.Cu2+ (out)CHEBI:29036
+ L-ascorbate (in)CHEBI:38290= Cu+ (out)CHEBI:49552+ CHEBI:15378 + CHEBI:59513 - L-ascorbate(in) + monodehydro-L-ascorbate radical(out) = L-ascorbate(out) + monodehydro-L-ascorbate radical(in)This reaction proceeds in the forward direction.
Cofactor
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | apical plasma membrane | |
Cellular Component | brush border membrane | |
Cellular Component | lysosomal membrane | |
Molecular Function | identical protein binding | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity | |
Molecular Function | transmembrane ascorbate ferrireductase activity | |
Molecular Function | transmembrane monodehydroascorbate reductase activity | |
Biological Process | ascorbate homeostasis | |
Biological Process | intracellular iron ion homeostasis | |
Biological Process | multicellular organismal-level iron ion homeostasis | |
Biological Process | response to iron ion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePlasma membrane ascorbate-dependent reductase CYBRD1
- EC number
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Metatheria > Didelphimorphia > Didelphidae > Monodelphis
Accessions
- Primary accessionF6PUC5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Apical cell membrane ; Multi-pass membrane protein
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 7-33 | Helical | ||||
Sequence: YCGFLGLLVSALLVGFLAVLFTLVWVV | ||||||
Transmembrane | 53-73 | Helical | ||||
Sequence: VLTVTGFVFIQGLAIIVYRLP | ||||||
Transmembrane | 85-106 | Helical | ||||
Sequence: FIHAGLNTIALILAIISLVAVF | ||||||
Transmembrane | 126-147 | Helical | ||||
Sequence: LIAVIFYTSQLLLGFLTFLLPC | ||||||
Transmembrane | 159-180 | Helical | ||||
Sequence: IHVYSGLLIFGTVIAAVLTGVT | ||||||
Transmembrane | 200-220 | Helical | ||||
Sequence: IFVNTLGILILVFGAVVFWIV |
Keywords
- Cellular component
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 16-221 | Cytochrome b561 | ||||
Sequence: SALLVGFLAVLFTLVWVVHYREGLGWDGGSQEFNWHPVLTVTGFVFIQGLAIIVYRLPWTWKCSKLLMKFIHAGLNTIALILAIISLVAVFDFHNTKNIPNMYSLHSWIGLIAVIFYTSQLLLGFLTFLLPCTPPALRAFIMPIHVYSGLLIFGTVIAAVLTGVTEKLIFTLKNPAYSTLPPEGIFVNTLGILILVFGAVVFWIVT | ||||||
Region | 230-284 | Disordered | ||||
Sequence: EPNAKLLQPNGSTPEGTDYSITGDFGNVDKSDEDGEAAARKRNLKLDEVGQRSTM | ||||||
Compositional bias | 234-249 | Polar residues | ||||
Sequence: KLLQPNGSTPEGTDYS | ||||||
Compositional bias | 256-277 | Basic and acidic residues | ||||
Sequence: NVDKSDEDGEAAARKRNLKLDE |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length284
- Mass (Da)31,435
- Last updated2011-07-27 v1
- Checksum4B99516504A96C07
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 234-249 | Polar residues | ||||
Sequence: KLLQPNGSTPEGTDYS | ||||||
Compositional bias | 256-277 | Basic and acidic residues | ||||
Sequence: NVDKSDEDGEAAARKRNLKLDE |
Keywords
- Technical term