F6P7Z9 · F6P7Z9_DANRE
- ProteinCarnitine O-palmitoyltransferase 1, muscle isoform
- Genecpt1b
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids770 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion.
Catalytic activity
- (R)-carnitine + hexadecanoyl-CoA = CoA + O-hexadecanoyl-(R)-carnitineThis reaction proceeds in the forward direction.
Pathway
Lipid metabolism; fatty acid beta-oxidation.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 471 | Proton acceptor | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | mitochondrial outer membrane | |
Cellular Component | mitochondrion | |
Molecular Function | carnitine O-palmitoyltransferase activity | |
Biological Process | carnitine metabolic process | |
Biological Process | energy homeostasis | |
Biological Process | fatty acid beta-oxidation | |
Biological Process | fatty acid metabolic process | |
Biological Process | long-chain fatty acid transport | |
Biological Process | response to (R)-carnitine | |
Biological Process | response to bacterium |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameCarnitine O-palmitoyltransferase 1, muscle isoform
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionF6P7Z9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Mitochondrion outer membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 104-126 | Helical | ||||
Sequence: VLSAILFATGLWLSVIFLLRYLL |
Keywords
- Cellular component
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-47 | Carnitine O-palmitoyltransferase N-terminal | ||||
Sequence: MAEAHQAVAFQFTVTPDGIDLQLSREVLKHIYISGVTSWKKRAIRFK | ||||||
Domain | 174-754 | Choline/carnitine acyltransferase | ||||
Sequence: LPVPSIDDTIRRYLESVRPLLDDEQYKQMETVANDFKKDPAPKLQKHLKLKSWWATNYVSDWWEEYIYLRGRDPIMVNSNFYTMDLLYVIPTYRQAARAGNVVHAMLQYRRKLERGELTPLRALGIVPMCSFQYERMFNTTRIPGIETDFVQHLKDRKHLVVYHRGRLFKVWLYYGGRHLWPSELELQFQRILDDKSEPQPGELKLPSLTAGNRVPWARARLKYFGEGVNRASLEAIETAAFFLTLDDEAHGYDPENIRSLDLYAKSLLHGKCYDRWFDKSFNLIVYKNGKMGVNTEHSWADSPIIGHMWEYVLATDCFHLGYTAEGHCKGDVNKTLAPPTRLQWDIPKACQEIIEGSYRIAKGIADDVDFHGCLFNEFGKGLIKKCRTSPDAFIQLALQLAQYRDKGEFCLTYESSMTRMFREGRTETVRSCTCESTAFVRAMEDDTTTNEQRLALFKQAAEKHQNMYRLAMTGAGIDRHLFCLYIVSKVMGIDSPFLKQVLSEPWRLSTSQTPQQQLNLIDTQKFPKYVSAGGGFGPVADDGYGVSYIIVGENLITFHISSKFSSPETDSFRFGQNIRQ |
Sequence similarities
Belongs to the carnitine/choline acetyltransferase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length770
- Mass (Da)88,450
- Last updated2018-06-20 v2
- ChecksumB6A6FEBBE0A143B8
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX276107 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |