F6NHA0 · F6NHA0_DANRE

Function

function

Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentadherens junction
Cellular Componentcell-cell contact zone
Cellular Componentcytoplasm
Cellular Componentcytoskeleton
Cellular Componentfocal adhesion
Cellular Componentplasma membrane
Cellular Componentpodosome
Molecular Functionactin filament binding
Molecular Functionalpha-catenin binding
Molecular Functionbeta-catenin binding
Molecular Functionstructural molecule activity
Biological Processatrioventricular valve morphogenesis
Biological Processcell adhesion
Biological Processheart contraction
Biological Processmembrane repolarization during cardiac muscle cell action potential
Biological Processsarcomere organization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Metavinculin

Gene names

    • Name
      vcla
    • Synonyms
      hm:zehn2160
      , im:6902790
      , vcl

Organism names

  • Taxonomic identifier
  • Strain
    • Tuebingen
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    F6NHA0
  • Secondary accessions
    • A0A8M2B2X1

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cell projection, podosome
Membrane
; Peripheral membrane protein

Keywords

Expression

Gene expression databases

Family & Domains

Features

Showing features for coiled coil, region, compositional bias.

TypeIDPosition(s)Description
Coiled coil360-387
Coiled coil538-593
Region837-890Disordered
Compositional bias859-873Pro residues
Compositional bias874-890Basic and acidic residues

Sequence similarities

Belongs to the vinculin/alpha-catenin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,066
  • Mass (Da)
    116,730
  • Last updated
    2018-06-20 v1
  • Checksum
    3E3FF1BC49FE2ECE
MPVFHTKTIESILEPVAQQISHLVIMHEEGEVDGKAIPDLTSPVAAVQAAVSNLVRVGKETVQTTEDKIMKRDMPSAFIKVENACAKLVEAAQMLRTDPYSVPARDYLIDGSRGILSGTSDLLLTFDEAEVRKIIRVCKGILEYLTVAEVVETMEDLITYTKNLGPGMTKMAKMIDERQQELTHQEHRVMLVTSMNTVKELLPVLISAIKIFVTTKCTKSHGVEEALKNRNYTFDKMTAEINEIIRVLQLTSWDEDAWANKDTEAMKRALALIESKMGQAKGWLRDPNALPGDPGEHALRQILDEAGKVGELCAGKERREILGTAKTLGQMTDQVSDVRARGQGATPMGMQKAQQVAQGLDILVGKVENAARKLEALTNAKQAIAKRIDNAQSWLADPNGGPEGEENIRALLAEAKRIADLCEDPKERDDILRSIGEIAGLTARLVELRRIGKGDTPEARALAKQIGTALQNLQAKTNRAVANMRPAKAAVTLEGKMEQALRWINNPGVDDHGVGQAAIRGLIAEGRRLASSLPGPYRQELLAKCEQVEQLMMQLADLAARGEGESPQARAVAAHLLEAIKDLKAKMQEAMTQEVSDVFSDTTTPIKLLAVAATAPLEAPNREEVFEERASNFENHASRLGATAEKAAAVGTANKSTVEGIQAAVKSARDLTPQVTSAARILLKNPGNQAAYEHFDTMKNQWIDNIEKMTSLVDEAIDTKSLLDASEEAIKKDIDKCRVAMANVQPQMLVAGATSIARRANRVLLVAKREVENSEDPKFRELVKAASDELGRTISPMVMAAKGVAGNIQDPGLQKGFLDSGYRILAAVGKVREAFQPQELDFPPPPPDLDQLHVNDDQAPPKPPLPEGEVPPPRPPPPEEKDEEFPEQKAGEMVSEPMMVAARSLHDEARKWSSKGNDIIGAAKRMALLMAEMSRLVRGGSGNKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTISTQLKILSTVKATMLGRTNISEEESEQATEMLVHNAQNLMQSVKETVREAEAASIKIRTDAGFTLRWVRKTPWYQ

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
B3DI32B3DI32_DANREvcla1131
A0A8M2B3M1A0A8M2B3M1_DANREvcla1130
A0A8M9QJN2A0A8M9QJN2_DANREvcla1067

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias859-873Pro residues
Compositional bias874-890Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CR762430
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CR788251
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CT025777
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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