Study shows that the integration of PDX1.2 into a heteromeric dodecamer assembly with PDX1.3 does not cause a major structural deviation from the overall architecture of the homomeric complex. Nonetheless the structure of the PDX1.2-PDX1.3 complex highlights enhanced flexibility in key catalytic regions for the initial steps of vitamin B6 biosynthesis.
X-ray structures of PDX1.3 from Arabidopsis thaliana the overall architecture of which is a dodecamer of (beta/alpha)8 barrels similar to the majority of its homologs is reported.
Data indicates a negative influence of PDX1.2 on vitamin B6 biosynthesis and a correlation between aberrant vitamin B6 content PDX1 gene expression and light sensitivity specifically for PDX1.3.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.