F6KSZ4 · F6KSZ4_HUMAN

  • Protein
    Hedgehog protein
  • Gene
    DHH
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    3/5

Function

function

Protein hedgehog N-product

The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development.

Protein hedgehog

The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.

Features

Showing features for binding site, site.

139550100150200250300350
TypeIDPosition(s)Description
Binding site90Ca2+ 2 (UniProtKB | ChEBI)
Binding site90Ca2+ 1 (UniProtKB | ChEBI)
Binding site95Ca2+ 1 (UniProtKB | ChEBI)
Binding site125Ca2+ 1 (UniProtKB | ChEBI)
Binding site126Ca2+ 1 (UniProtKB | ChEBI)
Binding site126Ca2+ 2 (UniProtKB | ChEBI)
Binding site129Ca2+ 2 (UniProtKB | ChEBI)
Binding site131Ca2+ 2 (UniProtKB | ChEBI)
Binding site140Zn2+ (UniProtKB | ChEBI)
Binding site147Zn2+ (UniProtKB | ChEBI)
Binding site182Zn2+ (UniProtKB | ChEBI)
Site197-198Cleavage; by autolysis
Site243Involved in cholesterol transfer
Site267Involved in auto-cleavage
Site270Essential for auto-cleavage

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Cellular ComponentGolgi membrane
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionpeptidase activity
Molecular Functiontransferase activity
Biological Processcell-cell signaling
Biological Processprotein autoprocessing

Keywords

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Hedgehog protein

Gene names

    • Name
      DHH

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    F6KSZ4

Subcellular Location

Sonic hedgehog protein

Endoplasmic reticulum membrane
Golgi apparatus membrane

Protein hedgehog N-product

Cell membrane
; Lipid-anchor

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_500334299223-395Hedgehog protein

Keywords

Proteomic databases

Interaction

Subunit

Multimer.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain196-303Hint
Domain304-348Hint

Sequence similarities

Belongs to the hedgehog family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    395
  • Mass (Da)
    43,448
  • Last updated
    2011-07-27 v1
  • Checksum
    AB41C72AA5B9F966
MALLTNLLPLCCLALLALPAQSCGPGRGPVGRRRYARKQLVPLLYKQFVPGVPERTLGASGPAEGRVARGSERFRDLVPNYNPDIIFKDENSGADRLMTERCKERVNALAIAVMNMWPGVRLRVTEGWDEDGHHAQDSLHYEGRALDITTSDRDRNKYGLLARLAVEAGFDWVYYESRNHVHVSVKADNSLAVRAGGCFPGNATVRLWSGERKGLRELHRGDWVLAADASGRVVPTPVLLFLDRDLQRRASFVAVETEWPPRKLLLTPWHLVFAARGPAPAPGDFAPVFARRLRAGDSVLAPGGDALRPARVARVAREEAVGVFAPLTAHGTLLVNDVLASCYAVLESHQWAHRAFAPLRLLHALGALLPGGAVQPTGMHWYSRLLYRLAEELLG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HQ607677
EMBL· GenBank· DDBJ
AEF38366.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

Disclaimer

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