F6KAF1 · F6KAF1_PHYMI
- ProteinNADH dehygrogenase subunit 2
- Genenad2
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids497 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | mitochondrion | |
Molecular Function | NADH dehydrogenase (ubiquinone) activity | |
Biological Process | ATP synthesis coupled electron transport |
Names & Taxonomy
Protein names
- Submitted names
Gene names
Encoded on
- Mitochondrion
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Sar > Stramenopiles > Oomycota > Peronosporales > Peronosporaceae > Phytophthora
Accessions
- Primary accessionF6KAF1
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 13-33 | Helical | ||||
Sequence: IIIPEFFLTTILLILLLFGVF | ||||||
Transmembrane | 45-67 | Helical | ||||
Sequence: IIKNITTIIIYLLLILLILTLNI | ||||||
Transmembrane | 79-102 | Helical | ||||
Sequence: LIINNFTQFIKVILILSTIVCFLI | ||||||
Transmembrane | 169-193 | Helical | ||||
Sequence: LKYFILGSIASGFILFGSSIIYAIT | ||||||
Transmembrane | 213-233 | Helical | ||||
Sequence: NINILISLSYGLIFILVGILF | ||||||
Transmembrane | 254-276 | Helical | ||||
Sequence: NISSFFAIVPKIAFIGILIRLFF | ||||||
Transmembrane | 282-302 | Helical | ||||
Sequence: ISYFFEIFFYIISFLSMLIGA | ||||||
Transmembrane | 314-335 | Helical | ||||
Sequence: LLAYSSISHVGFILIGFTSNML | ||||||
Transmembrane | 341-362 | Helical | ||||
Sequence: ILLYVLIYIITSINLWTSYLSL | ||||||
Transmembrane | 383-403 | Helical | ||||
Sequence: KLIAIIIIINIFSLAGIPPLA | ||||||
Transmembrane | 423-446 | Helical | ||||
Sequence: LVFFGILISVLSSFYYLKIIKIIY | ||||||
Transmembrane | 467-488 | Helical | ||||
Sequence: LIINTQFILFLFISPNIILVNL |
Keywords
- Cellular component
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 135-434 | NADH:quinone oxidoreductase/Mrp antiporter membrane subunit | ||||
Sequence: NHLITLYLAIELQSLSFYILTSTQKKSILSIEAGLKYFILGSIASGFILFGSSIIYAITGSLNFNNIFLILSNINFLENINILISLSYGLIFILVGILFKVGASPFHFWLPDVYEGAPNNISSFFAIVPKIAFIGILIRLFFEIFFNISYFFEIFFYIISFLSMLIGALSALQQKKIKRLLAYSSISHVGFILIGFTSNMLNNIPFILLYVLIYIITSINLWTSYLSLNINHKPIKYLTDLSNIHTINKLIAIIIIINIFSLAGIPPLAGFFSKLFIFFSAIKNNYFSLVFFGILISVLS |
Sequence similarities
Belongs to the complex I subunit 2 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length497
- Mass (Da)57,074
- Last updated2011-07-27 v1
- Checksum5BE74E7B49408D83
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HM590421 EMBL· GenBank· DDBJ | ADK76339.1 EMBL· GenBank· DDBJ | Genomic DNA |