F5Y554 · F5Y554_RAMTT
- ProteinKynurenine formamidase
- GenekynB
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids198 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.
Catalytic activity
- N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H+
Cofactor
Note: Binds 2 zinc ions per subunit.
Pathway
Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 8 | substrate | |||
Binding site | 38 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 42 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 44 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 44 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Active site | 48 | Proton donor/acceptor | |||
Binding site | 150 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 162 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 162 | Zn2+ 1 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | arylformamidase activity | |
Molecular Function | formamidase activity | |
Molecular Function | zinc ion binding | |
Biological Process | tryptophan catabolic process to kynurenine |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameKynurenine formamidase
- EC number
- Short namesKFA ; KFase
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Comamonadaceae > Ramlibacter
Accessions
- Primary accessionF5Y554
Proteomes
Interaction
Structure
Sequence
- Sequence statusComplete
- Length198
- Mass (Da)21,383
- Last updated2011-07-27 v1
- Checksum0B569B53522D000C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000245 EMBL· GenBank· DDBJ | AEG93894.1 EMBL· GenBank· DDBJ | Genomic DNA |