F5Y554 · F5Y554_RAMTT

Function

function

Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 zinc ions per subunit.

Pathway

Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site8substrate
Binding site38Zn2+ 1 (UniProtKB | ChEBI)
Binding site42Zn2+ 1 (UniProtKB | ChEBI)
Binding site44Zn2+ 2 (UniProtKB | ChEBI)
Binding site44Zn2+ 1 (UniProtKB | ChEBI)
Active site48Proton donor/acceptor
Binding site150Zn2+ 2 (UniProtKB | ChEBI)
Binding site162Zn2+ 2 (UniProtKB | ChEBI)
Binding site162Zn2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionarylformamidase activity
Molecular Functionformamidase activity
Molecular Functionzinc ion binding
Biological Processtryptophan catabolic process to kynurenine

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Kynurenine formamidase
  • EC number
  • Short names
    KFA
    ; KFase
  • Alternative names
    • Arylformamidase
    • N-formylkynurenine formamidase
      (FKF
      )

Gene names

    • Name
      kynB
    • Ordered locus names
      Rta_27910

Organism names

Accessions

  • Primary accession
    F5Y554

Proteomes

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the Cyclase 1 superfamily. KynB family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    198
  • Mass (Da)
    21,383
  • Last updated
    2011-07-27 v1
  • Checksum
    0B569B53522D000C
MHAGAPVFPGDTPYSQRWAATIAPGCPVNVSSLTLSPHVGAHADAPLHYDPQGEPVGALDLAPFLGRCRVIHALQPGPLVEWRHLEHAARGLPPRVLVRTYERAPVDRWDPALAAFAPQTVERLADLGVRLVGIDTASIDPAQSKELPSHQVIRRRGLRVLENLVLDGVPEGDYELVALPLKLMTADASPVRAVLRSL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000245
EMBL· GenBank· DDBJ
AEG93894.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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