F5XWJ7 · F5XWJ7_RAMTT

Function

function

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

Catalytic activity

Cofactor

FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site65-69FMN (UniProtKB | ChEBI)
Binding site69substrate
Binding site89FMN (UniProtKB | ChEBI)
Binding site114-118substrate
Binding site150FMN (UniProtKB | ChEBI)
Binding site183FMN (UniProtKB | ChEBI)
Binding site183substrate
Active site186Nucleophile
Binding site188substrate
Binding site228FMN (UniProtKB | ChEBI)
Binding site256FMN (UniProtKB | ChEBI)
Binding site257-258substrate
Binding site279FMN (UniProtKB | ChEBI)
Binding site308FMN (UniProtKB | ChEBI)
Binding site329-330FMN (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functiondihydroorotate dehydrogenase (quinone) activity
Biological Process'de novo' pyrimidine nucleobase biosynthetic process
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase (quinone)
  • EC number
  • Alternative names
    • DHOdehase
      (DHOD
      ; DHODase
      )
    • Dihydroorotate oxidase

Gene names

    • Name
      pyrD
    • Ordered locus names
      Rta_18600

Organism names

Accessions

  • Primary accession
    F5XWJ7

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Membrane

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain50-340Dihydroorotate dehydrogenase catalytic

Sequence similarities

Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    354
  • Mass (Da)
    38,074
  • Last updated
    2011-07-27 v1
  • Checksum
    0381C85A4F92EF2A
MPLLPYPLARPFLFHLDAERAHDLTLASLARLQGTPLQWAWRSRRVDDPVELAGLRFPNRVGLAAGLDKNARCIDAFAGMGFGFVEVGTVTPLAQPGNAKPRMFRLPQAQALVNRLGFNNEGLEAFVANVQRSAVRRRSLHDGGIVLGLNIGKNAATPIEDATRDYLTGLEGVYPHADYVTVNISSPNTQNLRALQSDEALDALLAALARRRAELEQRHGRRVPLFVKIAPDLDEAQVRVIAATLQRHGMDGVIATNTTLSRDAVQGLPHAQEAGGLSGAPVLEASNRVIRQLRAALGPRFPIVGVGGVMSGPDAVSKIEAGADLVQVYTGLIYRGPALAGEAAYALRAHGRRR

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000245
EMBL· GenBank· DDBJ
AEG92951.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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