F5HF47 · UL32_HHV8P

Function

function

Plays a role in efficient localization of neo-synthesized capsids to nuclear replication compartments, thereby controlling cleavage and packaging of virus genomic DNA (PubMed:29875246).
Facilitates thereby the transfer of newly replicated viral genomes to the packaging motor (PubMed:33554858).

Features

Showing features for binding site.

146750100150200250300350400450
TypeIDPosition(s)Description
Binding site52Zn2+ 1 (UniProtKB | ChEBI)
Binding site55Zn2+ 1 (UniProtKB | ChEBI)
Binding site130Zn2+ 1 (UniProtKB | ChEBI)
Binding site136Zn2+ 1 (UniProtKB | ChEBI)
Binding site191Zn2+ 3 (UniProtKB | ChEBI)
Binding site192Zn2+ 3 (UniProtKB | ChEBI)
Binding site296Zn2+ 2 (UniProtKB | ChEBI)
Binding site299Zn2+ 2 (UniProtKB | ChEBI)
Binding site366Zn2+ 2 (UniProtKB | ChEBI)
Binding site373Zn2+ 2 (UniProtKB | ChEBI)
Binding site415Zn2+ 3 (UniProtKB | ChEBI)
Binding site452Zn2+ 3 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componenthost cell nucleus
Cellular Componentviral envelope
Molecular Functionmetal ion binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Packaging protein UL32 homolog

Gene names

    • Name
      ORF68

Organism names

Accessions

  • Primary accession
    F5HF47

Proteomes

Subcellular Location

Host cytoplasm
Host nucleus
Note: Localizes to viral replication compartments.

Keywords

Phenotypes & Variants

Disruption phenotype

Deletion mutants maintain viral DNA replication and late gene expression but does not produce infectious virions. In addition, viral DNA is not cleaved after replication.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis52Strong loss of stability.
Mutagenesis373Strong loss of stability.
Mutagenesis415Strong loss of stability.
Mutagenesis452Strong loss of stability.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004237661-467Packaging protein UL32 homolog

Interaction

Subunit

Forms a homopentameric ring.

Structure

3D structure databases

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region52-136Zinc finger 1
Region191-452Zinc finger 3
Region296-373Zinc finger 2

Sequence similarities

Belongs to the herpesviridae UL32 protein family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    467
  • Mass (Da)
    51,911
  • Last updated
    2011-06-28 v1
  • Checksum
    3B3C423978D2A52C
MFVPWQLGTITRHRDELQKLLAASLLPEHPEESLGNPIMTQIHQSLQPSSPCRVCQLLFSLVRDSSTPMGFFEDYACLCFFCLYAPHCWTSTMAAAADLCEIMHLHFPEEEATYGLFGPGRLMGIDLQLHFFVQKCFKTTAAEKILGISNLQFLKSEFIRGMLTGTITCNFCFKTSWPRTDKEEATGPTPCCQITDTTTAPASGIPELARATFCGASRPTKPSLLPALIDIWSTSSELLDEPRPRLIASDMSELKSVVASHDPFFSPPLQADTSQGPCLMHPTLGLRYKNGTASVCLLCECLAAHPEAPKALQTLQCEVMGHIENNVKLVDRIAFVLDNPFAMPYVSDPLLRELIRGCTPQEIHKHLFCDPLCALNAKVVSEDVLFRLPREQEYKKLRASAAAGQLLDANTLFDCEVVQTLVFLFKGLQNARVGKTTSLDIIRELTAQLKRHRLDLAHPSQTSHLYA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF148805
EMBL· GenBank· DDBJ
AAD46496.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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