Results indicate that haplotypes that provide rapid N-acetyltransferase 1 (NAT1) and slow N-acetyltransferase 2 (NAT2) acetylating phenotypes may influence the development of acute lymphoblastic leukemia (ALL) in children.
The association of colorectal adenomas with the rs6983267 variant at 8q24 was considered as 'highly credible' the 'less credible' associations were identified with a further four variants of four independent genes: MTHFR c.677C>T p.A222V(rs1801133) TP53 c.215C>G p.R72P (rs1042522) NQO1 c.559C>T p.P187S (rs1800566) and NAT1 alleles imputed as fast acetylator genotypes. [meta-analysis]
The rs1799931(G>A) genotype was detected in the control population but not in the T2DM population. The wild type (G) allele frequency was higher in T2DM than controls. The mutant allele (A) in rs1799931(G>A) had a protective effect for T2DM.
Arylamine N-acetyltransferase polymorphisms in Han Chinese patients with ankylosing spondylitis and their correlation to the adverse drug reactions to sulfasalazine
the present study provides evidence for the role of NAT1 and NAT2 variations in NSCLP and indicates that interactions between the NAT1 and NAT2 genes may be important in susceptibility to NSCLP.
Epidemiological studies suggest that the NAT1 and NAT2 acetylation polymorphisms modify the risk of developing cancers of the urinary bladder colorectal breast head and neck and lung
NAT1 rapid acetylation alone as well as combination of NAT1 rapid-NAT2 slow acetylation did not modulate the risk of oral precancer and cancer in an Indian patient population.
individuals with NAT2 genotype have an elevated risk of colorectal cancer; however no evidence was found for association between NAT1 and 2 rapid genotype and colorectal adenoma risk
NAT1 is transcribed from a major promoter NATb and an alternative promoter NATa resulting in messenger RNAs (mRNAs) with distinct 5'-untranslated regions (UTRs).
NAT1 *10 and *11 significantly increase NAT1 protein level/enzyme activity enabling the classification of carriers into reference and rapid acetylators
effects of polymorphisms within NAT1 coding region and 3'-UTR and associated haplotypes on catalytic activity and mRNA and protein levels; findings provide support for reported associations of 1088T>A and 1095C>A polymorphisms with birth defects
Observational study of gene-disease association. (HuGE Navigator); There is a lack of association of the N-acetyltransferase NAT1*10 allele with prostate cancer incidence grade or stage among smokers in Finland.
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