Arylamine N-acetyltransferase 1 deficiency inhibits drug-induced cell death in breast cancer cells: switch from cytochrome C-dependent apoptosis to necroptosis.
Deletion of arylamine N-acetyltransferase 1 in MDA-MB-231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis.
Effect arylamine N-acetyltransferase 1 on morphology adhesion migration and invasion of MDA-MB-231 cells: role of matrix metalloproteinases and integrin alphaV.
We propose that phenotypic designations as 'rapid' and 'slow' acetylator should be discontinued for NAT1 alleles although these designations remain very appropriate for NAT2 alleles.
multiple populations in breast cancer can be segregated based on NAT1 mRNA levels; for patients with low expression overall survival is significantly less than for patients with intermediate or high expression; low NAT1 expression shows a distinct poor response to chemotherapy
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