F5H5L0 · F5H5L0_HUMAN
- ProteinLysosomal membrane ascorbate-dependent ferrireductase CYB561A3
- GeneCYB561A3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids199 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- Fe3+(out) + L-ascorbate(in) = Fe2+(out) + H+ + monodehydro-L-ascorbate radical(in)This reaction proceeds in the forward direction.Fe3+ (out)CHEBI:29034
+ L-ascorbate (in)CHEBI:38290= Fe2+ (out)CHEBI:29033+ CHEBI:15378 + CHEBI:59513
Cofactor
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | late endosome membrane | |
Molecular Function | oxidoreductase activity |
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLysosomal membrane ascorbate-dependent ferrireductase CYB561A3
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionF5H5L0
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Late endosome membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-28 | Helical | ||||
Sequence: FYLSCLLLGSLGSMCILFTIYWM | ||||||
Transmembrane | 49-69 | Helical | ||||
Sequence: VLMVAGMVVFYGGASLVYRLP | ||||||
Transmembrane | 81-104 | Helical | ||||
Sequence: LLHAALHLMAFVLTVVGLVAVFTF | ||||||
Transmembrane | 116-143 | Helical | ||||
Sequence: LHSWLGITTVFLFACQWFLGFAVFLLPW | ||||||
Transmembrane | 155-175 | Helical | ||||
Sequence: IHVFFGAAILSLSIASVISGI |
Keywords
- Cellular component
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 178 variants from UniProt as well as other sources including ClinVar and dbSNP.
Genetic variation databases
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 12-199 | Cytochrome b561 | ||||
Sequence: LLGSLGSMCILFTIYWMQYWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGITTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEKLFFSLKNTTRPYHSLPSEAVF |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusFragment
- Length199
- Mass (Da)22,540
- Last updated2016-10-05 v8
- Checksum58C2F2DD9F014276
Computationally mapped potential isoform sequences
There are 11 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q8NBI2 | CYAC3_HUMAN | CYB561A3 | 242 | ||
F5GX87 | F5GX87_HUMAN | CYB561A3 | 124 | ||
F5GWH8 | F5GWH8_HUMAN | CYB561A3 | 95 | ||
F5H832 | F5H832_HUMAN | CYB561A3 | 109 | ||
F5H5Y9 | F5H5Y9_HUMAN | CYB561A3 | 115 | ||
F5H684 | F5H684_HUMAN | CYB561A3 | 55 | ||
F5H466 | F5H466_HUMAN | CYB561A3 | 104 | ||
F5H121 | F5H121_HUMAN | CYB561A3 | 28 | ||
F5H0P5 | F5H0P5_HUMAN | CYB561A3 | 182 | ||
F5H240 | F5H240_HUMAN | CYB561A3 | 105 | ||
F5H1Q2 | F5H1Q2_HUMAN | CYB561A3 | 263 |
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 199 | |||||
Sequence: F |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP003108 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |