The ADCY7 deficiency resulted in decreased cell growth elevated apoptosis and lower c-Myc expression in cultured leukemia cells obtained from acute myeloid leukemia patients.
we found that single nucleotide polymorphisms in ADCY7 associate with alcohol dependence in women and these markers are also associated with ADCY7 expression (messenger RNA) levels.
Brain type VII adenylyl cyclase isoform plays a sex-specific role in the manifestation of a heritable form of depressive symptoms in genetically modified mice.
The first cytoplasmic domain (residues 506-584) of adenylyl cyclase (AC) type VII is an internal regulatory subunit interacting with a cardinal activator of AC (Gs alpha) and with the conserved first catalytic domain of type VII AC.
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