F5H4B4 · F227A_HUMAN
- ProteinProtein FAM227A
- GeneFAM227A
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids570 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein FAM227A
Gene names
Organism names
- Organism
- Taxonomic lineagecellular organisms > Eukaryota (eucaryotes) > Opisthokonta > Metazoa (metazoans) > Eumetazoa > Bilateria > Deuterostomia > Chordata (chordates) > Craniata > Vertebrata (vertebrates) > Gnathostomata (jawed vertebrates) > Teleostomi > Euteleostomi (bony vertebrates) > Sarcopterygii > Dipnotetrapodomorpha > Tetrapoda (tetrapods) > Amniota (amniotes) > Mammalia (mammals) > Theria > Eutheria (placentals) > Boreoeutheria > Euarchontoglires > Primates > Haplorrhini > Simiiformes > Catarrhini > Hominoidea (apes) > Hominidae (great apes) > Homininae > Homo
Accessions
- Primary accessionF5H4B4
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 646 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000419264 | 1-570 | Protein FAM227A | |||
Sequence: MNHFRKMEVINLTTLPMIPVDEHLAVSLVARNTMVKTVRKELENNPPSCLIGSMHQVNQKIADINLRTEPSANSLAIERFELEKKALREKTRSSPEDKVKRQRKSQYSCKGSELRHARSSVIKRKTADKNLLAELYQYSNFNSSKPNKLPNGVDFCDMVGNVVRAERDCLSGKHFCSGRELEKFLSSSSPRAIWLDSFWWIFHERYQPNKELQNNLFDRIAQHYALLLFRVPKSHSEEALLKRLPSLLSKAVYTSFCCCFPQSWFDTHEFKSDICNTMSLWISGTYPSPQSYDSWDYSELDPERFRREELMLYRRRLTKGREFSLFAGKRAFSQKPAQSRKFYHPQSSSANSPSEKTSSAKQNSEKSLRMQNTAKEHHCQTLVLKKPTQEVKRISEARECENMFPKKSCAACKSPELTSNLFNIYGKSPLIVYFLQNYASLQQHGKNVLIVRREKTTSTPDCTPTYTDVISETLCSMKKRKDNLNQLYQHHWTEWNYFDKHLKELQDNFSREMKNIDPKAADTKKANHMFIPPSAVNEESPDKKTKEGKGGEGKRRETEVEHFFPLTSKP | ||||||
Modified residue | 343 | Phosphotyrosine | ||||
Sequence: Y | ||||||
Modified residue | 348 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 349 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 87-112 | Disordered | ||||
Sequence: LREKTRSSPEDKVKRQRKSQYSCKGS | ||||||
Region | 336-374 | Disordered | ||||
Sequence: PAQSRKFYHPQSSSANSPSEKTSSAKQNSEKSLRMQNTA | ||||||
Compositional bias | 339-374 | Polar residues | ||||
Sequence: SRKFYHPQSSSANSPSEKTSSAKQNSEKSLRMQNTA | ||||||
Region | 519-570 | Disordered | ||||
Sequence: KAADTKKANHMFIPPSAVNEESPDKKTKEGKGGEGKRRETEVEHFFPLTSKP | ||||||
Compositional bias | 539-564 | Basic and acidic residues | ||||
Sequence: ESPDKKTKEGKGGEGKRRETEVEHFF |
Sequence similarities
Belongs to the FAM227 family.
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
F5H4B4-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length570
- Mass (Da)66,188
- Last updated2011-06-28 v1
- ChecksumAC7F64938A80E6F7
F5H4B4-2
- Name2
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A2R8YCE3 | A0A2R8YCE3_HUMAN | FAM227A | 622 | ||
A0A0A0MRD0 | A0A0A0MRD0_HUMAN | FAM227A | 651 |
Features
Showing features for alternative sequence, compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_044139 | 1-93 | in isoform 2 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_044140 | 94-98 | in isoform 2 | |||
Sequence: SPEDK → MLFSW | ||||||
Compositional bias | 339-374 | Polar residues | ||||
Sequence: SRKFYHPQSSSANSPSEKTSSAKQNSEKSLRMQNTA | ||||||
Sequence conflict | 391 | in Ref. 1; BAH13562 | ||||
Sequence: V → A | ||||||
Sequence conflict | 410 | in Ref. 1; BAH13562 | ||||
Sequence: A → T | ||||||
Compositional bias | 539-564 | Basic and acidic residues | ||||
Sequence: ESPDKKTKEGKGGEGKRRETEVEHFF |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AK301819 EMBL· GenBank· DDBJ | BAH13562.1 EMBL· GenBank· DDBJ | mRNA | ||
AL021707 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL022320 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AL035495 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |