Claudin-7 in keratinocytes is downregulated by the inhibition of HMG-CoA reductase and is highly expressed in the stratum granulosum of the psoriatic epidermis.
the findings of the present study demonstrated that the expression levels of CLDN1 3 7 and 8 varied between laryngeal squamous carcinoma tissues and nonneoplastic tissues
Authors have demonstrated a previously undescribed role of CLDN7 as a ccRCC suppressor and suggest that loss of CLDN7 potentiates EMT and tumor progression.
In the salivary gland ducts from patients with IgG4-related disease there was significant infiltration of IgG-positive plasma cells and expression of GBP-1 CLDN-7 and LSR was increased.
the present study revealed the distinct expression profiles of claudin5 7 and 8 in nonneoplastic mucosal tissues and gastric carcinoma tissues. Furthermore the expression of these claudin proteins was highly associated with metastatic progression and prognosis in patients with gastric carcinoma
CLDN7 expression is significantly elevated in gastric cancer tissues and the overexpression of CLDN7 is closely related to lymph node metastasis. CLDN7 executes an oncogenic function promoting cancer cell proliferation invasion and epithelial-mesenchymal transition.
DICFM approach may be applied as an appropriate approach to quantify the immunohistochemical staining of claudin-7 on the cell membrane and claudin-7 may serve as a marker for identification of lung cancer
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