F5B8V7 · CONA2_LUPAN
- ProteinConglutin alpha 2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids643 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Sulfur-rich seed storage protein. This protein found in the seeds of many leguminous and non-leguminous plants is the source of sulfur-containing amino acids in seed meals.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | nutrient reservoir activity |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Recommended nameConglutin alpha 2
- Cleaved into 2 chains
- Allergen nameLup an alpha-conglutin
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > fabids > Fabales > Fabaceae > Papilionoideae > 50 kb inversion clade > genistoids sensu lato > core genistoids > Genisteae > Lupinus
Accessions
- Primary accessionF5B8V7
Proteomes
Genome annotation databases
Phenotypes & Variants
Allergenic properties
Causes an allergic reaction in human.
Keywords
- Disease
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MAKPCLFSFSLCLLLLSSLCLA | ||||||
Chain | PRO_0000446135 | 23-457 | Conglutin alpha 2A subunit | |||
Sequence: ERPERYKECQLDRLNALEPDNRVESEGGVTETWNSNRPELRCAGVAFEKHTIQPQGLHLPSYTNYPQLIFIVEGEGALGISVPGCTETYEEAQQSQSSQDPRRRSSRSQSQEQEQQDSHQKIQYFREGDIIAIPPGIPYWTYNYGEQRLVAINLLDTTSLLNQLDPSPRRFYIAGNPEEEHPETQEQQGQQREQQQGAGGRRRGKHQQEQEEEGKNNVLSGFDPQFLTQAFNVDEEIINRLQNPDERLKQIVRVKRGLSIISPKSQEEEEEEEEEPRQRGQPERREERREEEKEEEEEEDEPRSRERYERQSRRRPGRQQGRQGEEQEEESESEQEGRGQQREWERTTRHRRAQGEEGEEEEEETSTRVRRQQGRGRGQEQGQEQGQEQEQEEEQQEGRRGRHGGRGRRSGQQREEEEEEQQQQQGRRKRQESRN | ||||||
Chain | PRO_5010895118 | 23-643 | Conglutin alpha 2 | |||
Sequence: ERPERYKECQLDRLNALEPDNRVESEGGVTETWNSNRPELRCAGVAFEKHTIQPQGLHLPSYTNYPQLIFIVEGEGALGISVPGCTETYEEAQQSQSSQDPRRRSSRSQSQEQEQQDSHQKIQYFREGDIIAIPPGIPYWTYNYGEQRLVAINLLDTTSLLNQLDPSPRRFYIAGNPEEEHPETQEQQGQQREQQQGAGGRRRGKHQQEQEEEGKNNVLSGFDPQFLTQAFNVDEEIINRLQNPDERLKQIVRVKRGLSIISPKSQEEEEEEEEEPRQRGQPERREERREEEKEEEEEEDEPRSRERYERQSRRRPGRQQGRQGEEQEEESESEQEGRGQQREWERTTRHRRAQGEEGEEEEEETSTRVRRQQGRGRGQEQGQEQGQEQEQEEEQQEGRRGRHGGRGRRSGQQREEEEEEQQQQQGRRKRQESRNGLEETICTARLLENIAKPSRADLYNPNAGRISSVNSLTLPILRWFQLSADYVNLYRNGIYAPHWNINANSVIFVTRGRGRVQVVNCQGNSVFNDDLRRGQLLVVPQNFVVAHQAGDEGFEFIAFKTNDLAATSPVKQVFRGIPAEVLANAFGLRLNQVSQLKYSGNQGPLVSPQSESEDHTLPKVA | ||||||
Disulfide bond | 31↔64 | |||||
Sequence: CQLDRLNALEPDNRVESEGGVTETWNSNRPELRC | ||||||
Disulfide bond | 107↔464 | Interchain (between A and B chains) | ||||
Sequence: CTETYEEAQQSQSSQDPRRRSSRSQSQEQEQQDSHQKIQYFREGDIIAIPPGIPYWTYNYGEQRLVAINLLDTTSLLNQLDPSPRRFYIAGNPEEEHPETQEQQGQQREQQQGAGGRRRGKHQQEQEEEGKNNVLSGFDPQFLTQAFNVDEEIINRLQNPDERLKQIVRVKRGLSIISPKSQEEEEEEEEEPRQRGQPERREERREEEKEEEEEEDEPRSRERYERQSRRRPGRQQGRQGEEQEEESESEQEGRGQQREWERTTRHRRAQGEEGEEEEEETSTRVRRQQGRGRGQEQGQEQGQEQEQEEEQQEGRRGRHGGRGRRSGQQREEEEEEQQQQQGRRKRQESRNGLEETIC | ||||||
Chain | PRO_0000446136 | 458-630 | Conglutin alpha 2B subunit | |||
Sequence: GLEETICTARLLENIAKPSRADLYNPNAGRISSVNSLTLPILRWFQLSADYVNLYRNGIYAPHWNINANSVIFVTRGRGRVQVVNCQGNSVFNDDLRRGQLLVVPQNFVVAHQAGDEGFEFIAFKTNDLAATSPVKQVFRGIPAEVLANAFGLRLNQVSQLKYSGNQGPLVSP |
Keywords
- PTM
Expression
Developmental stage
Accumulates during seed development.
Interaction
Subunit
Hexamer; each subunit is composed of an acidic and a basic chain derived from a single precursor and linked by a disulfide bond (By similarity).
Component of globulins complexes which accumulate in seeds (Probable)
Component of globulins complexes which accumulate in seeds (Probable)
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, compositional bias, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 36-261 | Cupin type-1 1 | ||||
Sequence: LNALEPDNRVESEGGVTETWNSNRPELRCAGVAFEKHTIQPQGLHLPSYTNYPQLIFIVEGEGALGISVPGCTETYEEAQQSQSSQDPRRRSSRSQSQEQEQQDSHQKIQYFREGDIIAIPPGIPYWTYNYGEQRLVAINLLDTTSLLNQLDPSPRRFYIAGNPEEEHPETQEQQGQQREQQQGAGGRRRGKHQQEQEEEGKNNVLSGFDPQFLTQAFNVDEEIIN | ||||||
Compositional bias | 110-126 | Polar residues | ||||
Sequence: TYEEAQQSQSSQDPRRR | ||||||
Region | 110-142 | Disordered | ||||
Sequence: TYEEAQQSQSSQDPRRRSSRSQSQEQEQQDSHQ | ||||||
Region | 190-243 | Disordered | ||||
Sequence: PRRFYIAGNPEEEHPETQEQQGQQREQQQGAGGRRRGKHQQEQEEEGKNNVLSG | ||||||
Compositional bias | 220-235 | Basic and acidic residues | ||||
Sequence: AGGRRRGKHQQEQEEE | ||||||
Region | 285-458 | Disordered | ||||
Sequence: PKSQEEEEEEEEEPRQRGQPERREERREEEKEEEEEEDEPRSRERYERQSRRRPGRQQGRQGEEQEEESESEQEGRGQQREWERTTRHRRAQGEEGEEEEEETSTRVRRQQGRGRGQEQGQEQGQEQEQEEEQQEGRRGRHGGRGRRSGQQREEEEEEQQQQQGRRKRQESRNG | ||||||
Compositional bias | 299-313 | Basic and acidic residues | ||||
Sequence: RQRGQPERREERREE | ||||||
Compositional bias | 325-348 | Basic and acidic residues | ||||
Sequence: RSRERYERQSRRRPGRQQGRQGEE | ||||||
Compositional bias | 356-379 | Basic and acidic residues | ||||
Sequence: EQEGRGQQREWERTTRHRRAQGEE | ||||||
Compositional bias | 430-458 | Basic and acidic residues | ||||
Sequence: RRSGQQREEEEEEQQQQQGRRKRQESRNG | ||||||
Domain | 470-616 | Cupin type-1 2 | ||||
Sequence: ENIAKPSRADLYNPNAGRISSVNSLTLPILRWFQLSADYVNLYRNGIYAPHWNINANSVIFVTRGRGRVQVVNCQGNSVFNDDLRRGQLLVVPQNFVVAHQAGDEGFEFIAFKTNDLAATSPVKQVFRGIPAEVLANAFGLRLNQVS | ||||||
Region | 623-643 | Disordered | ||||
Sequence: NQGPLVSPQSESEDHTLPKVA |
Sequence similarities
Belongs to the 11S seed storage protein (globulins) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length643
- Mass (Da)74,194
- Last updated2011-06-28 v1
- Checksum8A18C45A9A727165
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 110-126 | Polar residues | ||||
Sequence: TYEEAQQSQSSQDPRRR | ||||||
Compositional bias | 220-235 | Basic and acidic residues | ||||
Sequence: AGGRRRGKHQQEQEEE | ||||||
Compositional bias | 299-313 | Basic and acidic residues | ||||
Sequence: RQRGQPERREERREE | ||||||
Compositional bias | 325-348 | Basic and acidic residues | ||||
Sequence: RSRERYERQSRRRPGRQQGRQGEE | ||||||
Compositional bias | 356-379 | Basic and acidic residues | ||||
Sequence: EQEGRGQQREWERTTRHRRAQGEE | ||||||
Compositional bias | 430-458 | Basic and acidic residues | ||||
Sequence: RRSGQQREEEEEEQQQQQGRRKRQESRNG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HQ670407 EMBL· GenBank· DDBJ | AEB33710.1 EMBL· GenBank· DDBJ | mRNA | ||
KV862168 EMBL· GenBank· DDBJ | OIV90516.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CM007380 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |