F4Y9M3 · F4Y9M3_MUGCE

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strains
    • 05KL6_HT27
    • 05KP3_HT24
    • 07KL1_HT19
    • 07KL21_HT17
    • 07KL3_HT22
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Neoteleostei > Acanthomorphata > Ovalentaria > Mugilomorphae > Mugilidae > Mugil

Accessions

  • Primary accession
    F4Y9M3

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane24-54Helical
Transmembrane75-99Helical
Transmembrane119-142Helical
Transmembrane154-181Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-208Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    208
  • Mass (Da)
    22,265
  • Last updated
    2011-06-28 v1
  • Checksum
    E60C3A8F56AFED2F
GTALSLLIRAELSQPGALLGDDQIYNVIVTAHAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSGVEAGAGTGWTVYPPLASNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPATSQYQTPLFVWAVLITAVLLLLSLPVLAAGITMLLTDRNLNTSFFDPAGGGDPILYQHLFWF

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue208

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GU260679
EMBL· GenBank· DDBJ
ADK46918.1
EMBL· GenBank· DDBJ
Genomic DNA
GU260680
EMBL· GenBank· DDBJ
ADK46919.1
EMBL· GenBank· DDBJ
Genomic DNA
GU260681
EMBL· GenBank· DDBJ
ADK46920.1
EMBL· GenBank· DDBJ
Genomic DNA
GU260682
EMBL· GenBank· DDBJ
ADK46921.1
EMBL· GenBank· DDBJ
Genomic DNA
GU260683
EMBL· GenBank· DDBJ
ADK46922.1
EMBL· GenBank· DDBJ
Genomic DNA
GU260684
EMBL· GenBank· DDBJ
ADK46923.1
EMBL· GenBank· DDBJ
Genomic DNA
GU260685
EMBL· GenBank· DDBJ
ADK46924.1
EMBL· GenBank· DDBJ
Genomic DNA
GU260686
EMBL· GenBank· DDBJ
ADK46925.1
EMBL· GenBank· DDBJ
Genomic DNA
GU260687
EMBL· GenBank· DDBJ
ADK46926.1
EMBL· GenBank· DDBJ
Genomic DNA
GU260688
EMBL· GenBank· DDBJ
ADK46927.1
EMBL· GenBank· DDBJ
Genomic DNA
GU260689
EMBL· GenBank· DDBJ
ADK46928.1
EMBL· GenBank· DDBJ
Genomic DNA
GU260692
EMBL· GenBank· DDBJ
ADK46931.1
EMBL· GenBank· DDBJ
Genomic DNA
GU260693
EMBL· GenBank· DDBJ
ADK46932.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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