F4RBY2 · CSEPA_MELLP

Function

function

Rust effector delivered into infected tissues to modulate host functions and contribute to pathogen virulence (PubMed:30283062).
Binds the TGA1a-binding DNA sequence to repress the expression of genes involved in immune responses such as the defense-related transcription factors WRKY18, WRKY27, WRKY33, MYB51, the defense-related proteins NHL3, RPP8, YLS9, AZI1, CRK11 and the jasmonate pathway and regulation genes JAZ1, ASA1, ASB1. Other genes involved in diverse mechanisms also down-regulated include the chitinase CHI, the brassinosteroid-related genes BAS1, BES1 PAR1, BEE1, the salicylic acid-related gene NPR3, the ethylene-related response genes ARGOS and ARGOS-like (ARL), EBF2, ERF6, ETR2, RTE1, the carbon metabolism-related gene EXO, as well as the red/far red light signalization-related genes FAR1, GA2OX2, PAR1, PIF3, PKS4 (PubMed:30283062).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componenthost cell nucleolus

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Candidate secreted effector protein MPL124478
  • Short names
    CSEP MPL124478
  • Alternative names
    • Small secreted protein MPL124478
      (SSP MPL124478
      )

Gene names

    • ORF names
      MELLADRAFT_124478, MPL124478

Organism names

Accessions

  • Primary accession
    F4RBY2

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis29-38Impairs the translocation to he host nucleolus but still localizes to the nucleoplasm.

Miscellaneous

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-26
ChainPRO_500332071227-96Candidate secreted effector protein MPL124478

Expression

Induction

Expressed during host infection.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region27-51Disordered
Region29-36Nucleolar localization signal

Domain

The nucleolar localization signal (residues 29 to 38) is required for host nucleolar accumulation but not for the nuclear localization, nor for the augmented plant susceptibility to pathogens.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    96
  • Mass (Da)
    9,731
  • Last updated
    2011-06-28 v1
  • Checksum
    636AAFCCF9DB06A9
MMSQRYFKLLVVFLGLFAMIASIAEGKGRHKNGGGSRKKTNTVNNGGNNGGKPKVPMCGTTAATCSKGSPSCKGGKPTCGSKGAFNACGGNVKVTC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GL883095
EMBL· GenBank· DDBJ
EGG10259.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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