F4RBY2 · CSEPA_MELLP
- ProteinCandidate secreted effector protein MPL124478
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Rust effector delivered into infected tissues to modulate host functions and contribute to pathogen virulence (PubMed:30283062).
Binds the TGA1a-binding DNA sequence to repress the expression of genes involved in immune responses such as the defense-related transcription factors WRKY18, WRKY27, WRKY33, MYB51, the defense-related proteins NHL3, RPP8, YLS9, AZI1, CRK11 and the jasmonate pathway and regulation genes JAZ1, ASA1, ASB1. Other genes involved in diverse mechanisms also down-regulated include the chitinase CHI, the brassinosteroid-related genes BAS1, BES1 PAR1, BEE1, the salicylic acid-related gene NPR3, the ethylene-related response genes ARGOS and ARGOS-like (ARL), EBF2, ERF6, ETR2, RTE1, the carbon metabolism-related gene EXO, as well as the red/far red light signalization-related genes FAR1, GA2OX2, PAR1, PIF3, PKS4 (PubMed:30283062).
Binds the TGA1a-binding DNA sequence to repress the expression of genes involved in immune responses such as the defense-related transcription factors WRKY18, WRKY27, WRKY33, MYB51, the defense-related proteins NHL3, RPP8, YLS9, AZI1, CRK11 and the jasmonate pathway and regulation genes JAZ1, ASA1, ASB1. Other genes involved in diverse mechanisms also down-regulated include the chitinase CHI, the brassinosteroid-related genes BAS1, BES1 PAR1, BEE1, the salicylic acid-related gene NPR3, the ethylene-related response genes ARGOS and ARGOS-like (ARL), EBF2, ERF6, ETR2, RTE1, the carbon metabolism-related gene EXO, as well as the red/far red light signalization-related genes FAR1, GA2OX2, PAR1, PIF3, PKS4 (PubMed:30283062).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | extracellular region | |
Cellular Component | host cell nucleolus |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameCandidate secreted effector protein MPL124478
- Short namesCSEP MPL124478
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Basidiomycota > Pucciniomycotina > Pucciniomycetes > Pucciniales > Melampsoraceae > Melampsora
Accessions
- Primary accessionF4RBY2
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 29-38 | Impairs the translocation to he host nucleolus but still localizes to the nucleoplasm. | |||
Miscellaneous
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-26 | ||||
Chain | PRO_5003320712 | 27-96 | Candidate secreted effector protein MPL124478 | ||
Expression
Induction
Expressed during host infection.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 27-51 | Disordered | |||
Region | 29-36 | Nucleolar localization signal | |||
Domain
The nucleolar localization signal (residues 29 to 38) is required for host nucleolar accumulation but not for the nuclear localization, nor for the augmented plant susceptibility to pathogens.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length96
- Mass (Da)9,731
- Last updated2011-06-28 v1
- Checksum636AAFCCF9DB06A9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
GL883095 EMBL· GenBank· DDBJ | EGG10259.1 EMBL· GenBank· DDBJ | Genomic DNA |