F4MDB5 · F4MDB5_9INFA

Function

function

Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell mitochondrion
Cellular Componenthost cell nucleus
Cellular Componentvirion component
Molecular FunctionRNA binding
Biological Process7-methylguanosine mRNA capping
Biological Processcap snatching
Biological ProcessDNA-templated transcription
Biological Processsymbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Polymerase basic protein 2

Gene names

    • Name
      PB2

Organism names

  • Taxonomic identifier
  • Strain
    • A/slaty-backed gull/Japan/6KS0191/2006
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Negarnaviricota > Polyploviricotina > Insthoviricetes > Articulavirales > Orthomyxoviridae > Alphainfluenzavirus > Alphainfluenzavirus influenzae > Influenza A virus

Accessions

  • Primary accession
    F4MDB5

Subcellular Location

Keywords

Interaction

Subunit

Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-24Influenza RNA polymerase PB2 N-terminal region
Domain25-92Influenza RNA polymerase PB2 second
Domain95-236Influenza RNA polymerase PB2 middle
Domain238-307Polymerase basic protein 2 helical
Domain308-518Influenza RNA polymerase PB2 CAP binding
Domain519-668Influenza RNA polymerase PB2 sixth
Domain671-703Influenza RNA polymerase PB2 C-terminal

Sequence similarities

Belongs to the influenza viruses PB2 family.

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    703
  • Mass (Da)
    79,527
  • Last updated
    2011-06-28 v1
  • Checksum
    A7856C9F4F6BA9CC
QSRTREILTKTTVDHMAIIKKYTSGRQEKNPSLRMKWMMAMKYPITADKRIMEMIPERNEQGQTLWSKTNDAGSDRVMVSPLAVTWWNRNGPTTSTVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHADLSAKEAQDVIMEVVFPNEVGARILTSESQLTITKEKKEELQNCKIAPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGGEVRNDDVDQSLIIAARNIVRRATVSADPLASLLEMCYSTQIGGVRMVDILRQNPTEEQAVDICKAAMGLRISSSFSFGGFTFKRTSGSSVKKEEEVLTGNLQTLKIKIHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAIIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKTAKVLFQNWGIEPIDNVMGMVGILPDMTPSTEVSLRGVRISRMGVDEYSSTERVVVSIDRFLRVRDQQGNILLSPEEVSETQGTEKLTITYSSSMMWEINGPESVLVNTYQWIIRNWEIVKIQWSQDPTMLYNKVEFEPFQSLVPKAARGQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKATKRLAVLGKDAGALTEDPDEGKAGVESAVLRGFLILGKEDKRYGPALSINELSN

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue703

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CY089481
EMBL· GenBank· DDBJ
AEB39682.1
EMBL· GenBank· DDBJ
Viral cRNA

Similar Proteins

Disclaimer

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