F4KD38 · NRPC2_ARATH

Function

function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and NRPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.
Essential for the completion of the three rounds of mitosis in female megaspores required for the development of mature gametophytes (PubMed:18723889).

Catalytic activity

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentDNA-directed RNA polymerase complex
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-directed 5'-3' RNA polymerase activity
Molecular Functionmetal ion binding
Molecular Functionribonucleoside binding
Biological ProcessDNA-templated transcription
Biological Processmegagametogenesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    DNA-directed RNA polymerase III subunit 2
  • Alternative names
    • DNA-directed RNA polymerase III subunit RPC2
      (DNA polymerase I subunit C2
      ) (EC:2.7.7.6
      ) . EC:2.7.7.6 (UniProtKB | ENZYME | Rhea)
    • Nuclear RNA polymerase C2

Gene names

    • Name
      NRPC2
    • Synonyms
      RPC2
    • ORF names
      K18C1.1
    • Ordered locus names
      At5g45140

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    F4KD38
  • Secondary accessions
    • Q9FKF1

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Defect in seed production due to female gametophyte developmental arrest.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 36 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004340111-1161DNA-directed RNA polymerase III subunit 2

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for zinc finger.

TypeIDPosition(s)Description
Zinc finger1104-1125C4-type

Sequence similarities

Belongs to the RNA polymerase beta chain family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,161
  • Mass (Da)
    130,212
  • Last updated
    2011-06-28 v1
  • Checksum
    9A19AAD8E9E44DA9
MGLDQEDLDLTNDDHFIDKEKLSAPIKSTADKFQLVPEFLKVRGLVKQHLDSFNYFINVGIHKIVKANSRITSTVDPSIYLRFKKVRVGEPSIINVNTVENINPHMCRLADMTYAAPIFVNIEYVHGSHGNKAKSAKDNVIIGRMPIMLRSCRCVLHGKDEEELARLGECPLDPGGYFIIKGTEKVLLIQEQLSKNRIIIDSDKKGNINASVTSSTEMTKSKTVIQMEKEKIYLFLHRFVKKIPIIIVLKAMGMESDQEIVQMVGRDPRFSASLLPSIEECVSEGVNTQKQALDYLEAKVKKISYGTPPEKDGRALSILRDLFLAHVPVPDNNFRQKCFYVGVMLRRMIEAMLNKDAMDDKDYVGNKRLELSGQLISLLFEDLFKTMLSEAIKNVDHILNKPIRASRFDFSQCLNKDSRYSISLGLERTLSTGNFDIKRFRMHRKGMTQVLTRLSFIGSMGFITKISPQFEKSRKVSGPRSLQPSQWGMLCPCDTPEGESCGLVKNLALMTHVTTDEEEGPLVAMCYKLGVTDLEVLSAEELHTPDSFLVILNGLILGKHSRPQYFANSLRRLRRAGKIGEFVSVFTNEKQHCVYVASDVGRVCRPLVIADKGISRVKQHHMKELQDGVRTFDDFIRDGLIEYLDVNEENNALIALYESDGTTELDEGAEAAKADTTHIEIEPFTILGVVAGLIPYPHHNQSPRNTYQCAMGKQAMGNIAYNQLNRMDTLLYLLVYPQRPLLTTRTIELVGYDKLGAGQNATVAVMSFSGYDIEDAIVMNKSSLDRGFGRCIVMKKIVAMSQKYDNCTADRILIPQRTGPDAEKMQILDDDGLATPGEIIRPNDIYINKQVPVDTVTKFTSALSDSQYRPAREYFKGPEGETQVVDRVALCSDKKGQLCIKYIIRHTRRPELGDKFSSRHGQKGVCGIIIQQEDFPFSELGICPDLIMNPHGFPSRMTVGKMIELLGSKAGVSCGRFHYGSAFGERSGHADKVETISATLVEKGFSYSGKDLLYSGISGEPVEAYIFMGPIYYQKLKHMVLDKMHARGSGPRVMMTRQPTEGKSKNGGLRVGEMERDCLIAYGASMLIYERLMISSDPFEVQVCRACGLLGYYNYKLKKAVCTTCKNGDNIATMKLPYACKLLFQELQSMNVVPRLKLTEA

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8BFS9A0A1P8BFS9_ARATHNRPC2832

Sequence caution

The sequence BAB11387.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB012240
EMBL· GenBank· DDBJ
BAB11387.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002688
EMBL· GenBank· DDBJ
AED95209.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002688
EMBL· GenBank· DDBJ
ANM70451.1
EMBL· GenBank· DDBJ
Genomic DNA
AY123987
EMBL· GenBank· DDBJ
-mRNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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