F4JY12 · GFS12_ARATH
- ProteinProtein GFS12
- GeneGFS12
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1639 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
May act predominantly to suppress BCHC1, which itself is a negative factor in protein storage vacuole (PSV) trafficking regulation and plant effector triggered immunity (ETI). Required for ETI, but not for cell death.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | Cul4-RING E3 ubiquitin ligase complex | |
Molecular Function | ATP binding | |
Molecular Function | protein kinase activity | |
Biological Process | defense response to bacterium | |
Biological Process | protein phosphorylation | |
Biological Process | protein targeting to vacuole |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein GFS12
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionF4JY12
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Disruption phenotype
No visible phenotype. Accumulation of unprocessed 12S globulin in the seeds.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 123 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000434031 | 1-1639 | Protein GFS12 | ||
Proteomic databases
PTM databases
Expression
Tissue specificity
Weakly expressed in the cotyledons of germinating seedlings. Restricted to the vascular tissues of cotyledons. Detected in root tips, apical meristem, young flower buds and receptacles.
Gene expression databases
Interaction
Subunit
Interacts (via protein kinase 2 domain) with BCHC1 (via PH-BEACH domain).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, repeat, region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 206-294 | Protein kinase 1 | |||
Domain | 336-608 | BEACH | |||
Domain | 715-788 | Protein kinase 2 | |||
Repeat | 1290-1333 | WD 1 | |||
Repeat | 1336-1373 | WD 2 | |||
Region | 1377-1399 | Disordered | |||
Repeat | 1465-1499 | WD 3 | |||
Repeat | 1511-1549 | WD 4 | |||
Repeat | 1609-1639 | WD 5 | |||
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,639
- Mass (Da)183,399
- Last updated2011-06-28 v1
- Checksum2B71A76D1D035792
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 978-984 | in Ref. 3; CAQ77322 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC069328 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CP002688 EMBL· GenBank· DDBJ | AED92575.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
FM180203 EMBL· GenBank· DDBJ | CAQ77322.1 EMBL· GenBank· DDBJ | mRNA | ||
AY064158 EMBL· GenBank· DDBJ | AAL36064.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AY143925 EMBL· GenBank· DDBJ | AAN28864.1 EMBL· GenBank· DDBJ | mRNA |