F4JTJ6 · F4JTJ6_ARATH
- ProteinPantothenate kinase 2
- GenePANK2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids783 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the phosphorylation of pantothenate the first step in CoA biosynthesis. May play a role in the physiological regulation of the intracellular CoA concentration.
Catalytic activity
- (R)-4'-phosphopantetheine + H2O = (R)-pantetheine + phosphateThis reaction proceeds in the forward direction.
- (R)-4'-phosphopantetheine sulfonate + H2O = (R)-pantetheine sulfonate + phosphateThis reaction proceeds in the forward direction.
Cofactor
Protein has several cofactor binding sites:
Pathway
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | pantothenate kinase activity | |
Biological Process | coenzyme A biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePantothenate kinase 2
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionF4JTJ6
Proteomes
Organism-specific databases
Genome annotation databases
PTM/Processing
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-50 | Disordered | ||||
Sequence: MAGQEDEYDPILDNKREAEAKSQVSVAADKNMAPSTSGTPIHRSGSRPQL | ||||||
Compositional bias | 8-23 | Basic and acidic residues | ||||
Sequence: YDPILDNKREAEAKSQ | ||||||
Compositional bias | 28-46 | Polar residues | ||||
Sequence: ADKNMAPSTSGTPIHRSGS | ||||||
Domain | 576-777 | Damage-control phosphatase ARMT1-like metal-binding | ||||
Sequence: KRRGDAFARAFSAHLARLMEEPAAYGKLGLANLLELREECLREFQFVDAYRSIKQRENEASLAVLPDLLEELDSMSEEARLLTLIEGVLAANIFDWGSRACVDLYHKGTIIEIYRMSRNKMQRPWRVDDFDAFKERMLGSGGKQPHRHKRALLFVDNSGADVILGMLPLAREFLRRGTEVVLVANSLPALNDVTAMELPDIV |
Sequence similarities
Belongs to the type II pantothenate kinase family.
In the N-terminal section; belongs to the type II pantothenate kinase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length783
- Mass (Da)86,978
- Last updated2011-06-28 v1
- Checksum987763D2C854EACF
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q8L5Y9 | PANK2_ARATH | PANK2 | 901 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 8-23 | Basic and acidic residues | ||||
Sequence: YDPILDNKREAEAKSQ | ||||||
Compositional bias | 28-46 | Polar residues | ||||
Sequence: ADKNMAPSTSGTPIHRSGS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP002687 EMBL· GenBank· DDBJ | AEE86016.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002687 EMBL· GenBank· DDBJ | AEE86017.1 EMBL· GenBank· DDBJ | Genomic DNA |