F4JT82 · RPP2C_ARATH
- ProteinProbable disease resistance protein At4g19520
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1744 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Probable disease resistance protein.
Catalytic activity
- H2O + NAD+ = ADP-D-ribose + H+ + nicotinamideThis reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 80 | |||||
Sequence: E |
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Molecular Function | ADP binding | |
Molecular Function | ATP binding | |
Molecular Function | NAD+ nucleosidase activity | |
Molecular Function | NAD+ nucleotidase, cyclic ADP-ribose generating | |
Biological Process | cellular response to hypoxia | |
Biological Process | defense response | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProbable disease resistance protein At4g19520
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionF4JT82
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000444558 | 1-1744 | Probable disease resistance protein At4g19520 | |||
Sequence: MVDGKEVYISFNRWEDTIRHSFVSHLSAEFQRKGVSVFASEDSASDDRFAEESDAAIAKARVSVVIFSENFASSKGCLNEFLKVSKCRRSKGLVVVPVFYGLTNSIVKKHCLELKKMYPDDKVDEWRNALWDIADLRGGHVSSHKRSDSELVEKIVADVRQKLDRRGRIGVYSRLTKIEYLLCKQPGCIIRSLGIWGMAGIGKTTLARAAYDQLSRDFEASCFIEDFDREFQEKGFFGLLEKQLGVNPQVTRLSILLKTLRSKRILLVLDDVRKPLGATSFLCEFDWLGPGSLIIVTSQDKQVLVQCQVNEIYKVQGLNKHESLQLFSRCAFGKDVPDQNLLELSMKFVDYANGNPLALSICGKNLKGKTPLDMKSVVLELKRHLSDKIFVKLKSSYDALSVSEKEIFLDIVFTFRGANVDNVMQSLAGCGFFPRVGIEALVDKSFVTVSENRVQVNNLIYDVGLKIINDQSDEIGMCYRFVDASNSQSLIEHKEIRESEQGYEDVKAINLDTSNLPFKGHIAFQHMYNLRYLTIYSSINPTKDPDLFLPGDPQFLPPELRLLHWTCYPLHSFPQNFGFQYLVELNMPCSKLKKLWGGTKNLEVLKRITLSCSVQLLNVDELQYSPNIEKIDLKGCLELQSFPDTGQLQHLRIVDLSTCKKIKSFPKVPPSIRKLHLQGTGIRDLSSLNHSSESQRLTRKLENVSSSNQDHRKQVLKLKDSSHLGSLPDIVIFESLEVLDFSGCSELEDIQGFPQNLKRLYLAKTAIKEVPSSLCHHISKLVKLDMENCERLRDLPMGMSNMKYLAVLKLSGCSNLENIKELPRNLKELYLAGTAVKEFPSTLLETLSEVVLLDLENCKKLQGLPTGMSKLEFLVMLKLSGCSKLEIIVDLPLNLIELYLAGTAIRELPPSIGDLALLDTLDLKNCNRLRHLPMEMHNLNPLKVLDLSNCSELEVFTSSLPKVRELRPAPTVMLLRSKLPFCFFIFYEHRVTLSLYKARLQYIPEEIRWMPSLKTLDLSRNGFTEVPVSIKDFSKLLSLRLRYCENLRSLPQLPRSLQLLNAHGCSSLQLITPDFKQLPRYYTFSNCFGLPSHMVSEVLANAPAIVECRKPQQGLENALACSFCLPSPTSRDSKLYLQPGSSTMIILNPKTRSTLVGFAILVEVSFSKDFHDTAGLGFRCVCRWNDKKGHAHKRDNIFHCWAPGEVVPKINDDHMFVFFDLKMHPSILFEGDVFGILADLVVFEIFPVNKQEMHVGDSCTITKCGVYVINDAAGSSSGNTMTPQCSSMDSLKLLDGKGKKRLRVNYAGLKQREKALFLYIACLLGGEKADLLAQFLASTDFVIESTLEDLAGRYLIDISSNGEVMMPPLQRNFSREIIHMLPASTKELVSMASGSPCNRNNDVFVSFHGKDFRKQFISDFLKKLVYKGIRICIGDKILSRSLINKVIKESSIAVVVFSENYASSSLCLLQLMEIMKCWEELGQVVMPIFYKVNPSDIRNQSGHFGKGFKKTCKKTINDERQRWSRALTDAASIAGECSLNWASDADMIEKVANDIRKKLISSKKLGKQIQRVDCDHDNPWETEFNKCIERFFQLPYDGNHDESLVSLTTEKVIDMKQTLKEIYQITKVKLKNNLVGRRHINNICFMHILYEKCEERSSFNPTSLHTLYDNGIPYQVYTKRKKHMSGEEKAPIGGCVGCFYMGQNQGITKAGGGRTMPTAYPAAPQANQGYNAGAQPYPPTAYAV |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, repeat.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-163 | TIR 1 | ||||
Sequence: DGKEVYISFNRWEDTIRHSFVSHLSAEFQRKGVSVFASEDSASDDRFAEESDAAIAKARVSVVIFSENFASSKGCLNEFLKVSKCRRSKGLVVVPVFYGLTNSIVKKHCLELKKMYPDDKVDEWRNALWDIADLRGGHVSSHKRSDSELVEKIVADVRQKL | ||||||
Domain | 192-411 | NB-ARC | ||||
Sequence: SLGIWGMAGIGKTTLARAAYDQLSRDFEASCFIEDFDREFQEKGFFGLLEKQLGVNPQVTRLSILLKTLRSKRILLVLDDVRKPLGATSFLCEFDWLGPGSLIIVTSQDKQVLVQCQVNEIYKVQGLNKHESLQLFSRCAFGKDVPDQNLLELSMKFVDYANGNPLALSICGKNLKGKTPLDMKSVVLELKRHLSDKIFVKLKSSYDALSVSEKEIFLDI | ||||||
Repeat | 503-526 | LRR 1 | ||||
Sequence: YEDVKAINLDTSNLPFKGHIAFQH | ||||||
Repeat | 557-581 | LRR 2 | ||||
Sequence: PPELRLLHWTCYPLHSFPQNFGFQY | ||||||
Repeat | 583-602 | LRR 3 | ||||
Sequence: VELNMPCSKLKKLWGGTKNL | ||||||
Repeat | 603-626 | LRR 4 | ||||
Sequence: EVLKRITLSCSVQLLNVDELQYSP | ||||||
Repeat | 648-669 | LRR 5 | ||||
Sequence: LQHLRIVDLSTCKKIKSFPKVP | ||||||
Repeat | 670-692 | LRR 6 | ||||
Sequence: PSIRKLHLQGTGIRDLSSLNHSS | ||||||
Repeat | 710-733 | LRR 7 | ||||
Sequence: DHRKQVLKLKDSSHLGSLPDIVIF | ||||||
Repeat | 734-754 | LRR 8 | ||||
Sequence: ESLEVLDFSGCSELEDIQGFP | ||||||
Repeat | 755-777 | LRR 9 | ||||
Sequence: QNLKRLYLAKTAIKEVPSSLCHH | ||||||
Repeat | 779-802 | LRR 10 | ||||
Sequence: SKLVKLDMENCERLRDLPMGMSNM | ||||||
Repeat | 804-823 | LRR 11 | ||||
Sequence: YLAVLKLSGCSNLENIKELP | ||||||
Repeat | 824-846 | LRR 12 | ||||
Sequence: RNLKELYLAGTAVKEFPSTLLET | ||||||
Repeat | 848-871 | LRR 13 | ||||
Sequence: SEVVLLDLENCKKLQGLPTGMSKL | ||||||
Repeat | 892-915 | LRR 14 | ||||
Sequence: PLNLIELYLAGTAIRELPPSIGDL | ||||||
Repeat | 917-939 | LRR 15 | ||||
Sequence: LLDTLDLKNCNRLRHLPMEMHNL | ||||||
Repeat | 941-963 | LRR 16 | ||||
Sequence: PLKVLDLSNCSELEVFTSSLPKV | ||||||
Repeat | 987-1010 | LRR 17 | ||||
Sequence: YEHRVTLSLYKARLQYIPEEIRWM | ||||||
Repeat | 1011-1035 | LRR 18 | ||||
Sequence: PSLKTLDLSRNGFTEVPVSIKDFSK | ||||||
Repeat | 1037-1059 | LRR 19 | ||||
Sequence: LSLRLRYCENLRSLPQLPRSLQL | ||||||
Repeat | 1062-1086 | LRR 20 | ||||
Sequence: AHGCSSLQLITPDFKQLPRYYTFSN | ||||||
Domain | 1399-1559 | TIR 2 | ||||
Sequence: RNNDVFVSFHGKDFRKQFISDFLKKLVYKGIRICIGDKILSRSLINKVIKESSIAVVVFSENYASSSLCLLQLMEIMKCWEELGQVVMPIFYKVNPSDIRNQSGHFGKGFKKTCKKTINDERQRWSRALTDAASIAGECSLNWASDADMIEKVANDIRKKL |
Domain
The TIR domain mediates NAD+ hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.
Sequence similarities
Belongs to the disease resistance TIR-NB-LRR family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,744
- Mass (Da)196,906
- Last updated2011-06-28 v1
- ChecksumBDEF837606129AFB
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8B850 | A0A1P8B850_ARATH | At4g19520 | 1667 | ||
A0A1P8B852 | A0A1P8B852_ARATH | At4g19520 | 1540 | ||
A0A1P8B854 | A0A1P8B854_ARATH | At4g19520 | 1554 |
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL021768 EMBL· GenBank· DDBJ | CAA16929.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AL161551 EMBL· GenBank· DDBJ | CAB78954.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002687 EMBL· GenBank· DDBJ | AEE84194.1 EMBL· GenBank· DDBJ | Genomic DNA |