F4JP48 · MSH4_ARATH
- ProteinDNA mismatch repair protein MSH4
- GeneMSH4
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids792 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Involved in meiotic recombination in association with MSH5. Required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. Promotes homologous recombination through facilitating chiasma formation during prophase I. Involved in the control of class I crossovers formation.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 553-560 | ATP (UniProtKB | ChEBI) | |||
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | condensed nuclear chromosome | |
Cellular Component | germ cell nucleus | |
Cellular Component | plasmodesma | |
Molecular Function | ATP binding | |
Molecular Function | ATP-dependent DNA damage sensor activity | |
Molecular Function | mismatched DNA binding | |
Biological Process | homologous chromosome pairing at meiosis | |
Biological Process | homologous chromosome segregation | |
Biological Process | meiotic mismatch repair involved in reciprocal meiotic recombination |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameDNA mismatch repair protein MSH4
- Short namesAtMSH4
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionF4JP48
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: In pollen mother cells during meiosis, localizes to unsynapsed axes during leptotene and zygotene, but is not present on synapsed regions of zygotene nuclei.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Normal vegetative growth but severe reduction in fertility due to a decrease in chiasma frequency at metaphase I of meiosis.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 97 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000418367 | 1-792 | DNA mismatch repair protein MSH4 | ||
Proteomic databases
Expression
Structure
Sequence
- Sequence statusComplete
- Length792
- Mass (Da)89,015
- Last updated2011-06-28 v1
- ChecksumE1DCE70401C57A65
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8B358 | A0A1P8B358_ARATH | MSH4 | 738 |
Sequence caution
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 254 | in Ref. 1; AAT70180 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY646927 EMBL· GenBank· DDBJ | AAT70180.1 EMBL· GenBank· DDBJ | mRNA | ||
Z97343 EMBL· GenBank· DDBJ | CAB10519.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AL161546 EMBL· GenBank· DDBJ | CAB78741.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002687 EMBL· GenBank· DDBJ | AEE83882.1 EMBL· GenBank· DDBJ | Genomic DNA |