F4JBY2 · F4JBY2_ARATH

Function

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Co2+ (UniProtKB | Rhea| CHEBI:48828 )

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

thiamine diphosphate (UniProtKB | Rhea| CHEBI:58937 )

Note: Binds 1 thiamine pyrophosphate per subunit. During the reaction, the substrate forms a covalent intermediate with the cofactor.

Features

Showing features for binding site, site, active site.

Type
IDPosition(s)Description
Binding site103substrate
Site103Important for catalytic activity
Binding site143thiamine diphosphate (UniProtKB | ChEBI)
Binding site191-193thiamine diphosphate (UniProtKB | ChEBI)
Binding site233thiamine diphosphate (UniProtKB | ChEBI)
Binding site262thiamine diphosphate (UniProtKB | ChEBI)
Binding site339substrate
Binding site339thiamine diphosphate (UniProtKB | ChEBI)
Site339Important for catalytic activity
Binding site433substrate
Binding site460substrate
Active site487Proton donor
Binding site514thiamine diphosphate (UniProtKB | ChEBI)
Binding site538substrate
Binding site546substrate
Binding site550substrate
Binding site597substrate

GO annotations

AspectTerm
Molecular Functionmetal ion binding
Molecular Functiontransketolase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    transketolase
  • EC number

Gene names

    • Name
      TKL1
    • Synonyms
      AtTKL1
      , transketolase 1
    • Ordered locus names
      At3g60750

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    F4JBY2

Proteomes

Organism-specific databases

Genome annotation databases

PTM/Processing

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region22-52Disordered
Domain430-602Transketolase-like pyrimidine-binding

Sequence similarities

Belongs to the transketolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    740
  • Mass (Da)
    79,839
  • Last updated
    2011-06-28 v1
  • MD5 Checksum
    DEDF18BDBD8D105CCCF9979561429C03
MASTSSLALSQALLARAISHHGSDQRGSLPAFSGLKSTGSRASASSRRRIAQSMTKNRSLRPLVRAAAVETVEPTTDSSIVDKSVNSIRFLAIDAVEKAKSGHPGLPMGCAPMAHILYDEVMRYNPKNPYWFNRDRFVLSAGHGCMLLYALLHLAGYDSVQEDLKQFRQWGSKTPGHPENFETPGIEVTTGPLGQGIANAVGLALAEKHLAARFNKPDAEVVDHYTYAILGDGCQMEGISNEACSLAGHWGLGKLIAFYDDNHISIDGDTEIAFTENVDQRFEALGWHVIWVKNGNTGYDEIRAAIKEAKTVTDKPTLIKVTTTIGYGSPNKANSYSVHGAALGEKEVEATRNNLGWPYEPFQVPDDVKSHWSRHTPEGATLESDWSAKFAAYEKKYPEEASELKSIITGELPAGWEKALPTYTPESPGDATRNLSQQCLNALAKVVPGFLGGSADLASSNMTLLKAFGDFQKATPEERNLRFGVREHGMGAICNGIALHSPGLIPYCATFFVFTDYMRGAMRISALSEAGVIYVMTHDSIGLGEDGPTHQPIEHIASFRAMPNTLMFRPADGNETAGAYKIAVTKRKTPSILALSRQKLPHLPGTSIEGVEKGGYTISDDSSGNKPDVILIGTGSELEIAAQAAEVLRKDGKTVRVVSFVCWELFDEQSDEYKESVLPSDVSARVSIEAASTFGWGKIVGGKGKSIGINSFGASAPAPLLYKEFGITVEAVVDAAKSFF

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
Q8RWV0TKTC1_ARATHTKL-1741

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002686
EMBL· GenBank· DDBJ
AEE80104.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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