F4J4Y0 · P24D6_ARATH
- ProteinTransmembrane emp24 domain-containing protein p24delta6
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids217 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity).
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endoplasmic reticulum membrane | |
Biological Process | protein transport | |
Biological Process | vesicle-mediated transport |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameTransmembrane emp24 domain-containing protein p24delta6
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionF4J4Y0
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Endoplasmic reticulum membrane ; Single-pass type I membrane protein
Note: Cycles between the endoplasmic reticulum and Golgi via COPI and COPII dependent pathways (By similarity).
Mainly located in endoplasmic reticulum
Mainly located in endoplasmic reticulum
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 27-186 | Lumenal | |||
Transmembrane | 187-207 | Helical | |||
Topological domain | 208-217 | Cytoplasmic | |||
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 210 | Does not affect the subcellular location. | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 23 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain, glycosylation, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-26 | ||||
Chain | PRO_0000419786 | 27-217 | Transmembrane emp24 domain-containing protein p24delta6 | ||
Glycosylation | 84 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 116 | N-linked (GlcNAc...) asparagine | |||
Modified residue | 170 | Omega-N-methylated arginine | |||
Modified residue | 175 | Omega-N-methylated arginine | |||
Keywords
- PTM
Proteomic databases
Expression
Gene expression databases
Interaction
Subunit
Probably oligomerizes with other members of the EMP24/GP25L family. Associates with the COPI vesicle coat (coatomer). Associates with the COPII vesicle coat (coatomer).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain, coiled coil, motif.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 36-152 | GOLD | |||
Coiled coil | 138-160 | ||||
Motif | 210-211 | COPII vesicle coat-binding | |||
Motif | 210-217 | COPI vesicle coat-binding | |||
Domain
The cytoplasmic C-terminal domain contains a functional dilysine-retrieval motif, which is involved in the retrograde Golgi-to-ER transport of the protein.
Sequence similarities
Belongs to the EMP24/GP25L family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length217
- Mass (Da)24,230
- Last updated2011-06-28 v1
- Checksum50E4551419456984
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC011708 EMBL· GenBank· DDBJ | AAF19571.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002686 EMBL· GenBank· DDBJ | AEE74954.1 EMBL· GenBank· DDBJ | Genomic DNA |