F4J4Y0 · P24D6_ARATH

Function

function

Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side (By similarity).

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Biological Processprotein transport
Biological Processvesicle-mediated transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transmembrane emp24 domain-containing protein p24delta6
  • Alternative names
    • p24 family protein delta1d (p24delta1d)
    • p24 family protein delta6 (p24delta6)

Gene names

    • ORF names
      T7M13.14
    • Ordered locus names
      At3g10780

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    F4J4Y0
  • Secondary accessions
    • Q9SG84

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Endoplasmic reticulum membrane
; Single-pass type I membrane protein
Note: Cycles between the endoplasmic reticulum and Golgi via COPI and COPII dependent pathways (By similarity).
Mainly located in endoplasmic reticulum

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain27-186Lumenal
Transmembrane187-207Helical
Topological domain208-217Cytoplasmic

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis210Does not affect the subcellular location.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 23 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain, glycosylation, modified residue.

Type
IDPosition(s)Description
Signal1-26
ChainPRO_000041978627-217Transmembrane emp24 domain-containing protein p24delta6
Glycosylation84N-linked (GlcNAc...) asparagine
Glycosylation116N-linked (GlcNAc...) asparagine
Modified residue170Omega-N-methylated arginine
Modified residue175Omega-N-methylated arginine

Keywords

Proteomic databases

Expression

Gene expression databases

Interaction

Subunit

Probably oligomerizes with other members of the EMP24/GP25L family. Associates with the COPI vesicle coat (coatomer). Associates with the COPII vesicle coat (coatomer).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, coiled coil, motif.

Type
IDPosition(s)Description
Domain36-152GOLD
Coiled coil138-160
Motif210-211COPII vesicle coat-binding
Motif210-217COPI vesicle coat-binding

Domain

The cytoplasmic C-terminal domain contains a functional dilysine-retrieval motif, which is involved in the retrograde Golgi-to-ER transport of the protein.

Sequence similarities

Belongs to the EMP24/GP25L family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    217
  • Mass (Da)
    24,230
  • Last updated
    2011-06-28 v1
  • Checksum
    50E4551419456984
MAISPVLFIGLIYLAGGGSLFPGVEAIWLTVPESGERCVYEEIQANVVVVLDYICIDDAFTQLGPTLDVRVTSPYGKELYKIANVTHGQAAFTTSESGTFLACLAMHHDQSHHSVNSSVIVSLDWKMGIRAKDWDSVAKKEKIEGVELEIRRSTEYASAIRANILYLRIREAYMREINEKTNTRVNQLGLMSLGVAIVVSISQVLYLKRYFLKKKLI

Sequence caution

The sequence AAF19571.1 differs from that shown. Reason: Erroneous gene model prediction

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC011708
EMBL· GenBank· DDBJ
AAF19571.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002686
EMBL· GenBank· DDBJ
AEE74954.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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