F4IUX6 · RENT2_ARATH
- ProteinRegulator of nonsense transcripts UPF2
- GeneUPF2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1181 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Recruited by UPF3 associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA (By similarity).
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Required for plant development and adaptation to environmental stresses, including plant defense and response to wounding
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Required for plant development and adaptation to environmental stresses, including plant defense and response to wounding
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleolus | |
Cellular Component | perinuclear region of cytoplasm | |
Molecular Function | mRNA binding | |
Biological Process | defense response to bacterium | |
Biological Process | jasmonic acid mediated signaling pathway | |
Biological Process | long-day photoperiodism | |
Biological Process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | |
Biological Process | response to wounding | |
Biological Process | salicylic acid mediated signaling pathway |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameRegulator of nonsense transcripts UPF2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionF4IUX6
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Seedling lethal. Accumulation of mRNAs with premature termination codons (PTC). Photoperiod-dependent altered development and stress responses; in long days (16 hours light), altered organ morphologies (e.g. epinastic leaves, small rosette size, long seeds, some abnormal flowers and stunted stem growth), disturbed homeostasis of wounding-induced jasmonic acid and pathogen-elicited salicylic acid. Increased resistance to Pseudomonas syringae pv. tomato strain DC3000.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 68 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000421874 | 1-1181 | Regulator of nonsense transcripts UPF2 | |||
Sequence: MDHPEDESHSEKQDDEEALARLEEIKKSIEAKLTLRQNNLNPERPDSAYLRTLDSSIKRNTAVIKKLKQINEEQREGLMDDLRGVNLSKFVSEAVTAICEAKLKSSDIQAAVQICSLLHQRYKEFSASLTQGLLKVFFPGKSAEDLEADKNSKAMKKRSTLKLLLELYYVGVIEDSNIFINIIKDLTSVEQLKDRDTTQTNLTLLTSFARQGRIFLGLPISGQDEDFFKGLDVTADQKKSFKKAFNTYYDALADLLQSEHKLLLQMEKENAKLVNAKGELSEDSASSYEKLRKSYDHLYRNISSLAEALDMQPPVMPEDGTTRLTAGDEASPSGTVKDTSVPEPIWDDEDTKTFYECLPDLRAFVPAVLLGEAEPKSNEQSAKAKEKLSESSSEVVENQQTTEDTTEVSADSASMDDRSNAEQPKEKEEVEKEKAKDTKKEKGKEKDSEKKMEHEKEKGKSLDVANFERLLQRLPGCVSRDLIDQLTVEYCYLNSKTNRKKLVKALFNVPRTSLELLAYYSRMVATLASCMKDIPSMLVQMLEDEFNSLVHKKDQMNIETKIRNIRFIGELCKFKIVPAGLVFSCLKACLDEFTHHNIDVACNLLETCGRFLYRSPETTLRMTNMLDILMRLKNVKNLDPRQSTLVENAYYLCKPPERSARISKVRPPLHQYVRKLLFSDLDKDSIANVLKQLRKLPWSECEQYILKCFMKVHKGKYGQIHLIASLTSGLSRHHDEFVVAVVDEVLEEIRVGLELNEYGAQQKRLAHMRFLGELYNYEHVDSSVIFETLYLTLLYGHDTSEQEVLDPPEDFFRVRMVIILLETCGHYFDRGSSKKRLDQFLIHFQRYILSKGHLPLDIEFDLQDLFANLRPNMTRYSTIDEVNAAILQLEEREHASSGDKVSIERHSDTKPSNKSSSDVISSNGKSTAKDIRENGEAHGEESDSDSGSGSVVRDGQNEELDDGNHERGSESGDGDDYDDGDGPGSDDDKFRVRQKVVTVDLEEQADFDQELKALLQESMEQRKLELRGRPALNMTIPMSVFEGSGKDHHHFGRVVGENGEEVLDEENGEQREVQVKVLVKRGNKQQTRQMLIPSDCALVQSTKQKEAAELEEKQDIKRLVLEYNERDEEEANGLGTQILNWTSGGSRGSTRTGEGSGKSGGSRHRFYYHQGGGGSYHARRK |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Subunit
Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Interacts with UPF1 and UPF3 (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for coiled coil, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 6-41 | |||||
Sequence: DESHSEKQDDEEALARLEEIKKSIEAKLTLRQNNLN | ||||||
Domain | 61-264 | MIF4G 1 | ||||
Sequence: TAVIKKLKQINEEQREGLMDDLRGVNLSKFVSEAVTAICEAKLKSSDIQAAVQICSLLHQRYKEFSASLTQGLLKVFFPGKSAEDLEADKNSKAMKKRSTLKLLLELYYVGVIEDSNIFINIIKDLTSVEQLKDRDTTQTNLTLLTSFARQGRIFLGLPISGQDEDFFKGLDVTADQKKSFKKAFNTYYDALADLLQSEHKLLL | ||||||
Coiled coil | 260-309 | |||||
Sequence: HKLLLQMEKENAKLVNAKGELSEDSASSYEKLRKSYDHLYRNISSLAEAL | ||||||
Region | 309-348 | Disordered | ||||
Sequence: LDMQPPVMPEDGTTRLTAGDEASPSGTVKDTSVPEPIWDD | ||||||
Region | 375-459 | Disordered | ||||
Sequence: PKSNEQSAKAKEKLSESSSEVVENQQTTEDTTEVSADSASMDDRSNAEQPKEKEEVEKEKAKDTKKEKGKEKDSEKKMEHEKEKG | ||||||
Compositional bias | 378-392 | Basic and acidic residues | ||||
Sequence: NEQSAKAKEKLSESS | ||||||
Compositional bias | 393-417 | Polar residues | ||||
Sequence: SEVVENQQTTEDTTEVSADSASMDD | ||||||
Compositional bias | 418-459 | Basic and acidic residues | ||||
Sequence: RSNAEQPKEKEEVEKEKAKDTKKEKGKEKDSEKKMEHEKEKG | ||||||
Coiled coil | 425-451 | |||||
Sequence: KEKEEVEKEKAKDTKKEKGKEKDSEKK | ||||||
Domain | 469-655 | MIF4G 2 | ||||
Sequence: RLLQRLPGCVSRDLIDQLTVEYCYLNSKTNRKKLVKALFNVPRTSLELLAYYSRMVATLASCMKDIPSMLVQMLEDEFNSLVHKKDQMNIETKIRNIRFIGELCKFKIVPAGLVFSCLKACLDEFTHHNIDVACNLLETCGRFLYRSPETTLRMTNMLDILMRLKNVKNLDPRQSTLVENAYYLCKP | ||||||
Coiled coil | 539-559 | |||||
Sequence: VQMLEDEFNSLVHKKDQMNIE | ||||||
Domain | 672-871 | MIF4G 3 | ||||
Sequence: YVRKLLFSDLDKDSIANVLKQLRKLPWSECEQYILKCFMKVHKGKYGQIHLIASLTSGLSRHHDEFVVAVVDEVLEEIRVGLELNEYGAQQKRLAHMRFLGELYNYEHVDSSVIFETLYLTLLYGHDTSEQEVLDPPEDFFRVRMVIILLETCGHYFDRGSSKKRLDQFLIHFQRYILSKGHLPLDIEFDLQDLFANLRP | ||||||
Region | 735-755 | Binds to UPF3 | ||||
Sequence: DEFVVAVVDEVLEEIRVGLEL | ||||||
Compositional bias | 893-912 | Basic and acidic residues | ||||
Sequence: EHASSGDKVSIERHSDTKPS | ||||||
Region | 893-991 | Disordered | ||||
Sequence: EHASSGDKVSIERHSDTKPSNKSSSDVISSNGKSTAKDIRENGEAHGEESDSDSGSGSVVRDGQNEELDDGNHERGSESGDGDDYDDGDGPGSDDDKFR | ||||||
Compositional bias | 913-928 | Polar residues | ||||
Sequence: NKSSSDVISSNGKSTA | ||||||
Compositional bias | 929-943 | Basic and acidic residues | ||||
Sequence: KDIRENGEAHGEESD | ||||||
Compositional bias | 955-972 | Basic and acidic residues | ||||
Sequence: GQNEELDDGNHERGSESG | ||||||
Region | 981-1181 | Sufficient for interaction with UPF1 C-terminus | ||||
Sequence: DGPGSDDDKFRVRQKVVTVDLEEQADFDQELKALLQESMEQRKLELRGRPALNMTIPMSVFEGSGKDHHHFGRVVGENGEEVLDEENGEQREVQVKVLVKRGNKQQTRQMLIPSDCALVQSTKQKEAAELEEKQDIKRLVLEYNERDEEEANGLGTQILNWTSGGSRGSTRTGEGSGKSGGSRHRFYYHQGGGGSYHARRK | ||||||
Region | 999-1023 | Interaction with UPF1 | ||||
Sequence: VDLEEQADFDQELKALLQESMEQRK | ||||||
Region | 999-1102 | Necessary for interaction with UPF1 | ||||
Sequence: VDLEEQADFDQELKALLQESMEQRKLELRGRPALNMTIPMSVFEGSGKDHHHFGRVVGENGEEVLDEENGEQREVQVKVLVKRGNKQQTRQMLIPSDCALVQST | ||||||
Coiled coil | 1000-1021 | |||||
Sequence: DLEEQADFDQELKALLQESMEQ | ||||||
Region | 1066-1111 | Interaction with UPF1 | ||||
Sequence: ENGEQREVQVKVLVKRGNKQQTRQMLIPSDCALVQSTKQKEAAELE | ||||||
Region | 1129-1181 | Disordered | ||||
Sequence: EEANGLGTQILNWTSGGSRGSTRTGEGSGKSGGSRHRFYYHQGGGGSYHARRK | ||||||
Compositional bias | 1135-1157 | Polar residues | ||||
Sequence: GTQILNWTSGGSRGSTRTGEGSG |
Sequence similarities
Belongs to the RENT2 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,181
- Mass (Da)133,962
- Last updated2011-06-28 v1
- Checksum17C1964D4C402B65
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 378-392 | Basic and acidic residues | ||||
Sequence: NEQSAKAKEKLSESS | ||||||
Compositional bias | 393-417 | Polar residues | ||||
Sequence: SEVVENQQTTEDTTEVSADSASMDD | ||||||
Compositional bias | 418-459 | Basic and acidic residues | ||||
Sequence: RSNAEQPKEKEEVEKEKAKDTKKEKGKEKDSEKKMEHEKEKG | ||||||
Compositional bias | 893-912 | Basic and acidic residues | ||||
Sequence: EHASSGDKVSIERHSDTKPS | ||||||
Compositional bias | 913-928 | Polar residues | ||||
Sequence: NKSSSDVISSNGKSTA | ||||||
Compositional bias | 929-943 | Basic and acidic residues | ||||
Sequence: KDIRENGEAHGEESD | ||||||
Compositional bias | 955-972 | Basic and acidic residues | ||||
Sequence: GQNEELDDGNHERGSESG | ||||||
Compositional bias | 1135-1157 | Polar residues | ||||
Sequence: GTQILNWTSGGSRGSTRTGEGSG |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC004697 EMBL· GenBank· DDBJ | AAC28982.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002685 EMBL· GenBank· DDBJ | AEC09651.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK227294 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |