F4IUX6 · RENT2_ARATH

Function

function

Recruited by UPF3 associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3 stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA (By similarity).
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Required for plant development and adaptation to environmental stresses, including plant defense and response to wounding

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleolus
Cellular Componentperinuclear region of cytoplasm
Molecular FunctionmRNA binding
Biological Processdefense response to bacterium
Biological Processjasmonic acid mediated signaling pathway
Biological Processlong-day photoperiodism
Biological Processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Processresponse to wounding
Biological Processsalicylic acid mediated signaling pathway

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Regulator of nonsense transcripts UPF2
  • Alternative names
    • Nonsense mRNA reducing factor UPF2
    • Up-frameshift suppressor 2 homolog (AtUpf2)

Gene names

    • Name
      UPF2
    • ORF names
      T16B24.10
    • Ordered locus names
      At2g39260

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    F4IUX6
  • Secondary accessions
    • O80955

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Seedling lethal. Accumulation of mRNAs with premature termination codons (PTC). Photoperiod-dependent altered development and stress responses; in long days (16 hours light), altered organ morphologies (e.g. epinastic leaves, small rosette size, long seeds, some abnormal flowers and stunted stem growth), disturbed homeostasis of wounding-induced jasmonic acid and pathogen-elicited salicylic acid. Increased resistance to Pseudomonas syringae pv. tomato strain DC3000.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 68 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004218741-1181Regulator of nonsense transcripts UPF2

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Found in a post-splicing messenger ribonucleoprotein (mRNP) complex. Associates with the exon junction complex (EJC). Interacts with UPF1 and UPF3 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for coiled coil, domain, region, compositional bias.

TypeIDPosition(s)Description
Coiled coil6-41
Domain61-264MIF4G 1
Coiled coil260-309
Region309-348Disordered
Region375-459Disordered
Compositional bias378-392Basic and acidic residues
Compositional bias393-417Polar residues
Compositional bias418-459Basic and acidic residues
Coiled coil425-451
Domain469-655MIF4G 2
Coiled coil539-559
Domain672-871MIF4G 3
Region735-755Binds to UPF3
Compositional bias893-912Basic and acidic residues
Region893-991Disordered
Compositional bias913-928Polar residues
Compositional bias929-943Basic and acidic residues
Compositional bias955-972Basic and acidic residues
Region981-1181Sufficient for interaction with UPF1 C-terminus
Region999-1023Interaction with UPF1
Region999-1102Necessary for interaction with UPF1
Coiled coil1000-1021
Region1066-1111Interaction with UPF1
Region1129-1181Disordered
Compositional bias1135-1157Polar residues

Sequence similarities

Belongs to the RENT2 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,181
  • Mass (Da)
    133,962
  • Last updated
    2011-06-28 v1
  • Checksum
    17C1964D4C402B65
MDHPEDESHSEKQDDEEALARLEEIKKSIEAKLTLRQNNLNPERPDSAYLRTLDSSIKRNTAVIKKLKQINEEQREGLMDDLRGVNLSKFVSEAVTAICEAKLKSSDIQAAVQICSLLHQRYKEFSASLTQGLLKVFFPGKSAEDLEADKNSKAMKKRSTLKLLLELYYVGVIEDSNIFINIIKDLTSVEQLKDRDTTQTNLTLLTSFARQGRIFLGLPISGQDEDFFKGLDVTADQKKSFKKAFNTYYDALADLLQSEHKLLLQMEKENAKLVNAKGELSEDSASSYEKLRKSYDHLYRNISSLAEALDMQPPVMPEDGTTRLTAGDEASPSGTVKDTSVPEPIWDDEDTKTFYECLPDLRAFVPAVLLGEAEPKSNEQSAKAKEKLSESSSEVVENQQTTEDTTEVSADSASMDDRSNAEQPKEKEEVEKEKAKDTKKEKGKEKDSEKKMEHEKEKGKSLDVANFERLLQRLPGCVSRDLIDQLTVEYCYLNSKTNRKKLVKALFNVPRTSLELLAYYSRMVATLASCMKDIPSMLVQMLEDEFNSLVHKKDQMNIETKIRNIRFIGELCKFKIVPAGLVFSCLKACLDEFTHHNIDVACNLLETCGRFLYRSPETTLRMTNMLDILMRLKNVKNLDPRQSTLVENAYYLCKPPERSARISKVRPPLHQYVRKLLFSDLDKDSIANVLKQLRKLPWSECEQYILKCFMKVHKGKYGQIHLIASLTSGLSRHHDEFVVAVVDEVLEEIRVGLELNEYGAQQKRLAHMRFLGELYNYEHVDSSVIFETLYLTLLYGHDTSEQEVLDPPEDFFRVRMVIILLETCGHYFDRGSSKKRLDQFLIHFQRYILSKGHLPLDIEFDLQDLFANLRPNMTRYSTIDEVNAAILQLEEREHASSGDKVSIERHSDTKPSNKSSSDVISSNGKSTAKDIRENGEAHGEESDSDSGSGSVVRDGQNEELDDGNHERGSESGDGDDYDDGDGPGSDDDKFRVRQKVVTVDLEEQADFDQELKALLQESMEQRKLELRGRPALNMTIPMSVFEGSGKDHHHFGRVVGENGEEVLDEENGEQREVQVKVLVKRGNKQQTRQMLIPSDCALVQSTKQKEAAELEEKQDIKRLVLEYNERDEEEANGLGTQILNWTSGGSRGSTRTGEGSGKSGGSRHRFYYHQGGGGSYHARRK

Sequence caution

The sequence AAC28982.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence AK227294 differs from that shown. Reason: Frameshift

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias378-392Basic and acidic residues
Compositional bias393-417Polar residues
Compositional bias418-459Basic and acidic residues
Compositional bias893-912Basic and acidic residues
Compositional bias913-928Polar residues
Compositional bias929-943Basic and acidic residues
Compositional bias955-972Basic and acidic residues
Compositional bias1135-1157Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC004697
EMBL· GenBank· DDBJ
AAC28982.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002685
EMBL· GenBank· DDBJ
AEC09651.1
EMBL· GenBank· DDBJ
Genomic DNA
AK227294
EMBL· GenBank· DDBJ
-mRNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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