F4IS56 · ILK1_ARATH

Function

function

Functions as a link between plant defense pathways, stress responses and potassium homeostasis. Promotes osmotic stress sensitivity, responses to the bacterial-derived pathogen-associated molecular pattern (PAMP) flg22, and resistance to bacterial pathogens. Promotes the accumulation of POT5/HAK5, a potassium transporter that mediates high-affinity uptake during potassium deficiency.

Catalytic activity

Activity regulation

Kinase activity is suppressed by interaction with CML9.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site200-208ATP (UniProtKB | ChEBI)
Binding site222ATP (UniProtKB | ChEBI)
Active site319Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytoplasmic side of plasma membrane
Cellular Componentendoplasmic reticulum
Cellular Componentendoplasmic reticulum membrane
Molecular FunctionATP binding
Molecular Functionprotein kinase activity
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Molecular Functionprotein serine/threonine/tyrosine kinase activity
Biological Processinnate immune response
Biological Processprotein autophosphorylation
Biological Processresponse to osmotic stress

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Integrin-linked protein kinase 1
  • EC number
  • Alternative names
    • Ankyrin protein kinase 1

Gene names

    • Name
      ILK1
    • Synonyms
      APK1
    • ORF names
      F18O19.4
    • Ordered locus names
      At2g43850

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    F4IS56
  • Secondary accessions
    • F4IS57
    • Q8LL75
    • Q9SDB3

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Cell membrane
; Peripheral membrane protein
Endoplasmic reticulum membrane
; Peripheral membrane protein

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis222Decreases kinase activity.
Mutagenesis319Increases kinase activity.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 32 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00004417801-479Integrin-linked protein kinase 1
Modified residue17Phosphoserine
Modified residue26Phosphoserine

Post-translational modification

Autophosphorylated at Ser-17 and Ser-26.

Keywords

Proteomic databases

PTM databases

Expression

Induction

Induced by mannitol and the pathogen-associated molecular pattern (PAMP) flg22.

Gene expression databases

Interaction

Subunit

Interacts with CML9 and POT5/HAK5.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, repeat, domain.

TypeIDPosition(s)Description
Compositional bias29-57Polar residues
Region29-73Disordered
Compositional bias58-72Basic and acidic residues
Repeat77-106ANK 1
Repeat110-139ANK 2
Domain194-461Protein kinase

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

F4IS56-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    479
  • Mass (Da)
    54,415
  • Last updated
    2011-06-28 v1
  • Checksum
    2D4220B043E1F657
MENITAQLKRGISRQFSTGSIRRTLSRQFTRQSSLDPRRTNMRFSFGRQSSLDPIRRSPDSSKSDDEPHMSVPENLDSTMQLLFMASKGDVRGIEELLDEGIDVNSIDLDGRTALHIAACEGHLGVVKALLSRRANIDARDRWGSTAAADAKYYGNLDVYNLLKARGAKVPKTRKTPMTVSNPREVPEYELNPLEVQVRKSDGISKGAYQVAKWNGTRVSVKILDKDSYSDPERINAFRHELTLLEKVRHPNVIQFVGAVTQNIPMMIVVEYNPKGDLSVYLQKKGRLSPSKALRFALDIARGMNYLHECKPDPIIHCDLKPKNILLDRGGQLKISGFGMIRLSKISQDKAKVANHKAHIDLSNYYIAPEVYKDEIFDLRVDAHSFGVILYEITEGVPVFHPRPPEEVARMMCLEGKRPVFKTKSRSYPPDIKELIEKCWHPEAGIRPTFSEIIIRLDKIVANCSKQGWWKDTFKFPWK

F4IS56-2

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8B137A0A1P8B137_ARATHILK1478

Sequence caution

The sequence AAF18591.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias, alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Compositional bias29-57Polar residues
Compositional bias58-72Basic and acidic residues
Alternative sequenceVSP_059111207-208in isoform 2
Sequence conflict307in Ref. 3; AAN03744

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC002333
EMBL· GenBank· DDBJ
AAF18591.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002685
EMBL· GenBank· DDBJ
AEC10334.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
AEC10335.1
EMBL· GenBank· DDBJ
Genomic DNA
AF461113
EMBL· GenBank· DDBJ
AAN03744.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp