F4IS56 · ILK1_ARATH
- ProteinIntegrin-linked protein kinase 1
- GeneILK1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids479 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Functions as a link between plant defense pathways, stress responses and potassium homeostasis. Promotes osmotic stress sensitivity, responses to the bacterial-derived pathogen-associated molecular pattern (PAMP) flg22, and resistance to bacterial pathogens. Promotes the accumulation of POT5/HAK5, a potassium transporter that mediates high-affinity uptake during potassium deficiency.
Catalytic activity
- ATP + L-seryl-[protein] = ADP + H+ + O-phospho-L-seryl-[protein]
Activity regulation
Kinase activity is suppressed by interaction with CML9.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasmic side of plasma membrane | |
Cellular Component | endoplasmic reticulum | |
Cellular Component | endoplasmic reticulum membrane | |
Molecular Function | ATP binding | |
Molecular Function | protein kinase activity | |
Molecular Function | protein serine kinase activity | |
Molecular Function | protein serine/threonine kinase activity | |
Molecular Function | protein serine/threonine/tyrosine kinase activity | |
Biological Process | innate immune response | |
Biological Process | protein autophosphorylation | |
Biological Process | response to osmotic stress |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameIntegrin-linked protein kinase 1
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionF4IS56
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Endoplasmic reticulum membrane ; Peripheral membrane protein
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 222 | Decreases kinase activity. | ||||
Sequence: K → A | ||||||
Mutagenesis | 319 | Increases kinase activity. | ||||
Sequence: D → N |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 32 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000441780 | 1-479 | Integrin-linked protein kinase 1 | |||
Sequence: MENITAQLKRGISRQFSTGSIRRTLSRQFTRQSSLDPRRTNMRFSFGRQSSLDPIRRSPDSSKSDDEPHMSVPENLDSTMQLLFMASKGDVRGIEELLDEGIDVNSIDLDGRTALHIAACEGHLGVVKALLSRRANIDARDRWGSTAAADAKYYGNLDVYNLLKARGAKVPKTRKTPMTVSNPREVPEYELNPLEVQVRKSDGISKGAYQVAKWNGTRVSVKILDKDSYSDPERINAFRHELTLLEKVRHPNVIQFVGAVTQNIPMMIVVEYNPKGDLSVYLQKKGRLSPSKALRFALDIARGMNYLHECKPDPIIHCDLKPKNILLDRGGQLKISGFGMIRLSKISQDKAKVANHKAHIDLSNYYIAPEVYKDEIFDLRVDAHSFGVILYEITEGVPVFHPRPPEEVARMMCLEGKRPVFKTKSRSYPPDIKELIEKCWHPEAGIRPTFSEIIIRLDKIVANCSKQGWWKDTFKFPWK | ||||||
Modified residue | 17 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 26 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Autophosphorylated at Ser-17 and Ser-26.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Induction
Induced by mannitol and the pathogen-associated molecular pattern (PAMP) flg22.
Gene expression databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, repeat, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 29-57 | Polar residues | ||||
Sequence: FTRQSSLDPRRTNMRFSFGRQSSLDPIRR | ||||||
Region | 29-73 | Disordered | ||||
Sequence: FTRQSSLDPRRTNMRFSFGRQSSLDPIRRSPDSSKSDDEPHMSVP | ||||||
Compositional bias | 58-72 | Basic and acidic residues | ||||
Sequence: SPDSSKSDDEPHMSV | ||||||
Repeat | 77-106 | ANK 1 | ||||
Sequence: DSTMQLLFMASKGDVRGIEELLDEGIDVNS | ||||||
Repeat | 110-139 | ANK 2 | ||||
Sequence: DGRTALHIAACEGHLGVVKALLSRRANIDA | ||||||
Domain | 194-461 | Protein kinase | ||||
Sequence: LEVQVRKSDGISKGAYQVAKWNGTRVSVKILDKDSYSDPERINAFRHELTLLEKVRHPNVIQFVGAVTQNIPMMIVVEYNPKGDLSVYLQKKGRLSPSKALRFALDIARGMNYLHECKPDPIIHCDLKPKNILLDRGGQLKISGFGMIRLSKISQDKAKVANHKAHIDLSNYYIAPEVYKDEIFDLRVDAHSFGVILYEITEGVPVFHPRPPEEVARMMCLEGKRPVFKTKSRSYPPDIKELIEKCWHPEAGIRPTFSEIIIRLDKIV |
Sequence similarities
Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
F4IS56-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length479
- Mass (Da)54,415
- Last updated2011-06-28 v1
- Checksum2D4220B043E1F657
F4IS56-2
- Name2
- Differences from canonical
- 207-208: GA → AS
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A1P8B137 | A0A1P8B137_ARATH | ILK1 | 478 |
Sequence caution
Features
Showing features for compositional bias, alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 29-57 | Polar residues | ||||
Sequence: FTRQSSLDPRRTNMRFSFGRQSSLDPIRR | ||||||
Compositional bias | 58-72 | Basic and acidic residues | ||||
Sequence: SPDSSKSDDEPHMSV | ||||||
Alternative sequence | VSP_059111 | 207-208 | in isoform 2 | |||
Sequence: GA → AS | ||||||
Sequence conflict | 307 | in Ref. 3; AAN03744 | ||||
Sequence: L → F |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC002333 EMBL· GenBank· DDBJ | AAF18591.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002685 EMBL· GenBank· DDBJ | AEC10334.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002685 EMBL· GenBank· DDBJ | AEC10335.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF461113 EMBL· GenBank· DDBJ | AAN03744.1 EMBL· GenBank· DDBJ | mRNA |