F4IMQ0 · FLX_ARATH

Function

function

Transactivator required for FRIGIDA-mediated activation of FLC and for the expression of the repressors of flowering AGL27/MAF1 and AGL31/MAF2. Does not alter expression of known activators of FLC expression. Not required for the photoperiod response or for the vernalization response. Not redundant with FLXL4.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Biological Processcell differentiation
Biological Processflower development

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein FLC EXPRESSOR
  • Short names
    AtFLX
  • Alternative names
    • Protein SUPPRESSOR OF FRI 5

Gene names

    • Name
      FLX
    • Synonyms
      SUF5
    • ORF names
      E13.14
    • Ordered locus names
      At2g30120

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    F4IMQ0
  • Secondary accessions
    • O64735
    • Q93ZA1

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Cytoplasm
Nucleus
Note: homodimers present in the cytosol and heterodimers with FRI and FES1 detected only in the nucleus.

Keywords

Phenotypes & Variants

Disruption phenotype

Early flowering. Decreased level of H3K4me3 and histone H3 and H4 acetylation in the region spanning the transcription-translation start site of FLC, but not of UFC or DFC.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis176In flx-3; early flowering.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 28 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004237341-288Protein FLC EXPRESSOR

Proteomic databases

Expression

Tissue specificity

Expressed in roots and leaves. Expressed in shoot and root apical meristems and vascular tissues.

Gene expression databases

Interaction

Subunit

Homodimer. Component of the transcription activator complex FRI-C composed of FRI, FRL1, SUF4, FLX and FES1. Interacts with FES1 and (via N-terminus) with FRI (via C-terminus). Interacts with SWC6, TAF14B and RIN1, three components of the SWR1 chromatin-remodeling complex.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY F4IMQ0BIM1 Q9LEZ33EBI-4447281, EBI-617095

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for coiled coil, region.

TypeIDPosition(s)Description
Coiled coil38-94
Coiled coil132-231
Region225-257Disordered

Sequence similarities

Belongs to the FLX family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

F4IMQ0-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    288
  • Mass (Da)
    32,086
  • Last updated
    2011-06-28 v1
  • Checksum
    123F1678A852DD96
MAGRDRYIPSSAVSTSSSSRLLESQLIESDRNRARSVILEDRIAIQHREIQSLLNDNQRLAVAHIGLKDQLNVAKRELERLLETAVKVKAEGEAKVREVYQNALRMEAEARVIDGLGAELGQVRSDVQRLGSDRQELATELAMFDDEMAKAKPNSDRAIEVKLEIEILRGEIRKGRAALELEKKTRASNLHHERGMEKTIDHLNREIVKLEEELVDLETKAREANAAAEAAPTPSPGLAASYGNNTDDIYGGQGRQYPEANGTHELVLREKSYVHRLVSVQLVQVSVG

F4IMQ0-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8B1N9A0A1P8B1N9_ARATHAt2g30120179
A0A1P8B1P6A0A1P8B1P6_ARATHAt2g30120294
A0A1P8B1P9A0A1P8B1P9_ARATHAt2g30120270

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_053267177-288in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC004165
EMBL· GenBank· DDBJ
AAC16960.2
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
AEC08347.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
AEC08348.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002685
EMBL· GenBank· DDBJ
ANM62825.1
EMBL· GenBank· DDBJ
Genomic DNA
AY057695
EMBL· GenBank· DDBJ
AAL15325.1
EMBL· GenBank· DDBJ
mRNA
AY116952
EMBL· GenBank· DDBJ
AAM51586.1
EMBL· GenBank· DDBJ
mRNA
AK221657
EMBL· GenBank· DDBJ
BAD95329.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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