F4I1T7 · NP214_ARATH

Function

function

Required for normal embryogenesis and seed viability. Involved in the first asymmetrical cell division of the zygote. Regulates the number and planes of cell divisions required for generating the normal embryo proper and suspensor, apical-basal axis, cotyledons and meristem.

Miscellaneous

Named LONO after a Hawaiian god associated with fertility, agriculture, rainfall and music.

GO annotations

all annotationsall molecular functionnucleotide bindingmolecular_functionnucleic acid bindingdna bindingchromatin bindingdna-binding transcription factor activityrna bindingcytoskeletal motor activitycatalytic activitynuclease activitysignaling receptor bindingstructural molecule activitytransporter activitybindingprotein bindingtranslation factor activity, rna bindinglipid bindingkinase activitytransferase activityhydrolase activityoxygen bindingenzyme regulator activitycarbohydrate bindingsignaling receptor activitytranslation regulator activitytranscription regulator activityother molecular functionall biological processcarbohydrate metabolic processgeneration of precursor metabolites and energynucleobase-containing compound metabolic processdna metabolic processtranslationlipid metabolic processtransportresponse to stresscell cyclecell communicationsignal transductioncell-cell signalingmulticellular organism developmentcircadian rhythmbiological_processmetabolic processcatabolic processbiosynthetic processresponse to light stimulusresponse to external stimulustropismresponse to biotic stimulusresponse to abiotic stimulusresponse to endogenous stimulusembryo developmentpost-embryonic developmentfruit ripeningabscissionpollinationflower developmentcellular processprogrammed cell deathphotosynthesiscellular component organizationcell growthprotein metabolic processcellular homeostasissecondary metabolic processreproductive processcell differentiationprotein modification processgrowthepigenetic regulation of gene expressionresponse to chemicalanatomical structure developmentregulation of molecular functionother biological processall cellular componentcellular_componentextracellular regioncell wallintracellular anatomical structurenucleusnuclear envelopenucleoplasmnucleoluscytoplasmmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuscytosolribosomecytoskeletonplasma membranechloroplastplastidthylakoidmembraneexternal encapsulating structureother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmitochondrion
Cellular Componentnuclear pore
Molecular Functionstructural constituent of nuclear pore
Biological Processembryo development ending in seed dormancy
Biological ProcessmRNA transport
Biological Processprotein transport
Biological ProcessRNA export from nucleus
Biological Processzygote asymmetric cell division

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Nuclear pore complex protein NUP214
  • Alternative names
    • Nucleoporin 214
    • Protein EMBRYO DEFECTIVE 1011
    • Protein LNO1
    • Protein LONO1

Gene names

    • Name
      NUP214
    • Synonyms
      EMB1011
      , LNO1
    • ORF names
      T5A14.5
    • Ordered locus names
      At1g55540

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    F4I1T7
  • Secondary accessions
    • F4I1T6
    • Q94C88
    • Q9ZVV0

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Lethal when homozygous. Knockdown alleles have no obvious defect in growth and development.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 220 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004310791-1819Nuclear pore complex protein NUP214

Proteomic databases

PTM databases

Expression

Tissue specificity

Highly expressed in reproductive tissues, such as flowers and early developing seeds. Detected at low levels in vegetative tissues, such as leaves, shoots, stems or roots. Expressed in anthers, stigma papilla, embryo and endosperm.

Gene expression databases

Interaction

Subunit

Part of the nuclear pore complex (NPC). The NPC has an eight-fold symmetrical structure comprising a central transport channel and two rings, the cytoplasmic and nuclear rings, to which eight filaments are attached. The cytoplasmic filaments have loose ends, while the nuclear filaments are joined in a distal ring, forming a nuclear basket. NPCs are highly dynamic in configuration and composition, and can be devided in 3 subcomplexes, the NUP62 subcomplex, the NUP107-160 subcomplex and the NUP93 subcomplex, containing approximately 30 different nucleoporin proteins Interacts (via N-terminus) with RH38.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, repeat, compositional bias, coiled coil.

TypeIDPosition(s)Description
Region494-515Disordered
Repeat533-5341
Region533-180121 X 2 AA repeats of F-G
Repeat550-5512
Repeat586-5873
Compositional bias594-615Polar residues
Region594-646Disordered
Compositional bias626-643Polar residues
Region693-724Disordered
Coiled coil839-868
Compositional bias974-990Polar residues
Region974-999Disordered
Compositional bias1073-1145Polar residues
Region1073-1154Disordered
Repeat1204-12054
Repeat1226-12275
Repeat1307-13086
Region1319-1472Disordered
Compositional bias1331-1419Polar residues
Compositional bias1427-1472Polar residues
Compositional bias1494-1526Polar residues
Region1494-1577Disordered
Repeat1527-15287
Repeat1559-15608
Repeat1562-15639
Repeat1578-157910
Repeat1582-158311
Region1612-1643Disordered
Repeat1621-162212
Repeat1637-163813
Repeat1657-165814
Repeat1672-167315
Repeat1678-167916
Repeat1750-175117
Repeat1760-176118
Repeat1781-178219
Repeat1784-178520
Region1795-1819Disordered
Repeat1800-180121
Compositional bias1804-1819Polar residues

Domain

Contains FG repeats mediating the translocation through the NPC by interacting with transport factors.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

F4I1T7-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,819
  • Mass (Da)
    192,930
  • Last updated
    2011-06-28 v1
  • Checksum
    2F5771A153DB287B
MSRVEIEEDTEGDRISTNDYYFERIGEPISIKEDDAQYDLENPPSQPLAISERHAVLFVAHSSGFFVGRTNDVISASKNSNGNGDKVFIQDLSLVDVPVGDVRILSLSADDSILAVTVAADIHFFSVDSLLKKDAKPSFSYSPDESGFVKDFRWRRNDKHSYLVLSNTGKLFHGIDNAPPRHVMDAVDAVEWSSKGSYIAVAQDNSLRIFSSKFNEKRCIALSFDSWIGDSDEDCFVKVDSIRWVRNNCILLGCFQLIEGREENYLVQVIRSPDGKISDGSTNLVALSFSDLFPCSMDDLVPVGVGPHLLFSYIDQCKLAVTANRKSIDEHIVLLDWSSGDDKSAVSVVDIDRETFLPRIGLQENNDDNTVMGLCIDRVSIEGTVNVRSGDDELKELQPYFVLVCLTLEGKLVMFNVASVAGRPASSDTDLASSSDIEDAYTPLIEDDLSKQSSEKHQQLNIAVQNDQKHLNTEKFSTEQRLPNENIFSKEFESVKSSVSGDNNKKQEPYAEKPLQVEDAQQSMIPRLSGTSFGQLPMSLGYDTNKFAGFGPALPVSEKLQKDIFAQSNSMHLQANVESKSTAAFFGSPGLQNAILQSPQNTSSQPWSSGKSVSPPDFVSGPFPSMRDTQHKQSVQSGTGYVNPPMSIKDKSVQVIETGRVSALSNLSPLLGQNQDTNEGVEKIEPIPSIRASQLSQQVKSSFEKSASHQQHKTPLSTGPLRLEHNMSNQPSNINEMAREMDTLLQSIEGPGGFKDSCAFILKSNVEELEQGLESLAGKCQTWKSTIHEQQAEIQHLLDKTIQVLAKKTYMEGMYKQTADNQYWQLWNRQKLNPELEAKRQHIMKLNKDLTHQLIELERYFNRLELDRYNEDGGHPVARRGVPNRSAPSRRVQSLHSLHNTMSSQLAAAEQLSECLSKQMTYLKIDSPVKKNVKQELFETIGIPYDASFSSPDAVKAKNASSAKNLLLSSIPASINQQSRQRQSSAMKNSDPETARRRRESLDRVIFNWAAFEPPKTTVKRMLLQEQQKTGMNQQTVLSERLRSANNTQDRSLLHVKDHASPVVSSNKGIMESFQQDTSEAQSTPFKTRPPMPQSNSPFTISPISASKPSFNWSGNKSSNTTSYAEESAPSQIKDTRTVSQPGGSSFLPKRPVASTVLEQTEKKAGEFKFSEAKANAFVETAAGSVQRLSTTSSGSDFESSKGFGAQFSTMSSGAPASSFSSKSLFGFNSSSSIPGDKFTFPAVTAPLSGTPLDSTSTLFTASSAPVSSSSQDPVPASIPISSAPVPQTFSVTSTSTVSATGFNVPFGKPLTSVKVDLNQAAPSTPSPSPGPTAGFTFNLPALSPSSPEMVSSSTGQSSLFPPSAPTSQVSSDQASATSSLTDSSRLFSSTSLSSTPPITPPDAFQSPQVSTPSSAVPITEPVSEPKKPEAQSSSILSTQSTVDSVANATKTQNEPLPVKSEISNPGTTVTPVSSSGFLSGFSSGTQSSLASMAAPSFSWPGSSQPQQLSSTPAPFPASSPTSASPFGEKKDIVDTQEDEMDEEAPEASQTTELSMGSFGGFGLGSTPNPGAPKTNPFGGPFGNATTTTSNPFNMTVPSGELFKPASFNFQNPQPSQPAGFGSFSVTPSQTPAQSGFGQPSQIGGGQQALGSVLGSFGQSRQIGAGLPGATFGSPTGFGGSNPGSGLPNAPASGGFAAAGSSATGGFAAMASAGRGFAGASSTPTGGFAALASGSGGFAGAAPGGGGGGFGGLGSGTGGFGGFAPQGSSGGFAGAAGGGGFGGFGGQAQGQAGGGGFSAFGGNSGATGKPSELFTQMRK

F4I1T7-2

Sequence caution

The sequence AAD10642.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias, alternative sequence.

TypeIDPosition(s)Description
Compositional bias594-615Polar residues
Compositional bias626-643Polar residues
Compositional bias974-990Polar residues
Alternative sequenceVSP_0571261005-1007in isoform 2
Compositional bias1073-1145Polar residues
Compositional bias1331-1419Polar residues
Compositional bias1427-1472Polar residues
Compositional bias1494-1526Polar residues
Compositional bias1804-1819Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC005223
EMBL· GenBank· DDBJ
AAD10642.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CP002684
EMBL· GenBank· DDBJ
AEE33262.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE33263.1
EMBL· GenBank· DDBJ
Genomic DNA
AY035068
EMBL· GenBank· DDBJ
AAK59573.2
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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