F4I1T7 · NP214_ARATH
- ProteinNuclear pore complex protein NUP214
- GeneNUP214
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1819 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for normal embryogenesis and seed viability. Involved in the first asymmetrical cell division of the zygote. Regulates the number and planes of cell divisions required for generating the normal embryo proper and suspensor, apical-basal axis, cotyledons and meristem.
Miscellaneous
Named LONO after a Hawaiian god associated with fertility, agriculture, rainfall and music.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | mitochondrion | |
Cellular Component | nuclear pore | |
Molecular Function | structural constituent of nuclear pore | |
Biological Process | embryo development ending in seed dormancy | |
Biological Process | mRNA transport | |
Biological Process | protein transport | |
Biological Process | RNA export from nucleus | |
Biological Process | zygote asymmetric cell division |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameNuclear pore complex protein NUP214
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionF4I1T7
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Lethal when homozygous. Knockdown alleles have no obvious defect in growth and development.
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 220 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000431079 | 1-1819 | Nuclear pore complex protein NUP214 | |||
Sequence: MSRVEIEEDTEGDRISTNDYYFERIGEPISIKEDDAQYDLENPPSQPLAISERHAVLFVAHSSGFFVGRTNDVISASKNSNGNGDKVFIQDLSLVDVPVGDVRILSLSADDSILAVTVAADIHFFSVDSLLKKDAKPSFSYSPDESGFVKDFRWRRNDKHSYLVLSNTGKLFHGIDNAPPRHVMDAVDAVEWSSKGSYIAVAQDNSLRIFSSKFNEKRCIALSFDSWIGDSDEDCFVKVDSIRWVRNNCILLGCFQLIEGREENYLVQVIRSPDGKISDGSTNLVALSFSDLFPCSMDDLVPVGVGPHLLFSYIDQCKLAVTANRKSIDEHIVLLDWSSGDDKSAVSVVDIDRETFLPRIGLQENNDDNTVMGLCIDRVSIEGTVNVRSGDDELKELQPYFVLVCLTLEGKLVMFNVASVAGRPASSDTDLASSSDIEDAYTPLIEDDLSKQSSEKHQQLNIAVQNDQKHLNTEKFSTEQRLPNENIFSKEFESVKSSVSGDNNKKQEPYAEKPLQVEDAQQSMIPRLSGTSFGQLPMSLGYDTNKFAGFGPALPVSEKLQKDIFAQSNSMHLQANVESKSTAAFFGSPGLQNAILQSPQNTSSQPWSSGKSVSPPDFVSGPFPSMRDTQHKQSVQSGTGYVNPPMSIKDKSVQVIETGRVSALSNLSPLLGQNQDTNEGVEKIEPIPSIRASQLSQQVKSSFEKSASHQQHKTPLSTGPLRLEHNMSNQPSNINEMAREMDTLLQSIEGPGGFKDSCAFILKSNVEELEQGLESLAGKCQTWKSTIHEQQAEIQHLLDKTIQVLAKKTYMEGMYKQTADNQYWQLWNRQKLNPELEAKRQHIMKLNKDLTHQLIELERYFNRLELDRYNEDGGHPVARRGVPNRSAPSRRVQSLHSLHNTMSSQLAAAEQLSECLSKQMTYLKIDSPVKKNVKQELFETIGIPYDASFSSPDAVKAKNASSAKNLLLSSIPASINQQSRQRQSSAMKNSDPETARRRRESLDRVIFNWAAFEPPKTTVKRMLLQEQQKTGMNQQTVLSERLRSANNTQDRSLLHVKDHASPVVSSNKGIMESFQQDTSEAQSTPFKTRPPMPQSNSPFTISPISASKPSFNWSGNKSSNTTSYAEESAPSQIKDTRTVSQPGGSSFLPKRPVASTVLEQTEKKAGEFKFSEAKANAFVETAAGSVQRLSTTSSGSDFESSKGFGAQFSTMSSGAPASSFSSKSLFGFNSSSSIPGDKFTFPAVTAPLSGTPLDSTSTLFTASSAPVSSSSQDPVPASIPISSAPVPQTFSVTSTSTVSATGFNVPFGKPLTSVKVDLNQAAPSTPSPSPGPTAGFTFNLPALSPSSPEMVSSSTGQSSLFPPSAPTSQVSSDQASATSSLTDSSRLFSSTSLSSTPPITPPDAFQSPQVSTPSSAVPITEPVSEPKKPEAQSSSILSTQSTVDSVANATKTQNEPLPVKSEISNPGTTVTPVSSSGFLSGFSSGTQSSLASMAAPSFSWPGSSQPQQLSSTPAPFPASSPTSASPFGEKKDIVDTQEDEMDEEAPEASQTTELSMGSFGGFGLGSTPNPGAPKTNPFGGPFGNATTTTSNPFNMTVPSGELFKPASFNFQNPQPSQPAGFGSFSVTPSQTPAQSGFGQPSQIGGGQQALGSVLGSFGQSRQIGAGLPGATFGSPTGFGGSNPGSGLPNAPASGGFAAAGSSATGGFAAMASAGRGFAGASSTPTGGFAALASGSGGFAGAAPGGGGGGFGGLGSGTGGFGGFAPQGSSGGFAGAAGGGGFGGFGGQAQGQAGGGGFSAFGGNSGATGKPSELFTQMRK |
Proteomic databases
PTM databases
Expression
Tissue specificity
Highly expressed in reproductive tissues, such as flowers and early developing seeds. Detected at low levels in vegetative tissues, such as leaves, shoots, stems or roots. Expressed in anthers, stigma papilla, embryo and endosperm.
Gene expression databases
Interaction
Subunit
Part of the nuclear pore complex (NPC). The NPC has an eight-fold symmetrical structure comprising a central transport channel and two rings, the cytoplasmic and nuclear rings, to which eight filaments are attached. The cytoplasmic filaments have loose ends, while the nuclear filaments are joined in a distal ring, forming a nuclear basket. NPCs are highly dynamic in configuration and composition, and can be devided in 3 subcomplexes, the NUP62 subcomplex, the NUP107-160 subcomplex and the NUP93 subcomplex, containing approximately 30 different nucleoporin proteins Interacts (via N-terminus) with RH38.
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, repeat, compositional bias, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 494-515 | Disordered | ||||
Sequence: SVKSSVSGDNNKKQEPYAEKPL | ||||||
Repeat | 533-534 | 1 | ||||
Sequence: FG | ||||||
Region | 533-1801 | 21 X 2 AA repeats of F-G | ||||
Sequence: FGQLPMSLGYDTNKFAGFGPALPVSEKLQKDIFAQSNSMHLQANVESKSTAAFFGSPGLQNAILQSPQNTSSQPWSSGKSVSPPDFVSGPFPSMRDTQHKQSVQSGTGYVNPPMSIKDKSVQVIETGRVSALSNLSPLLGQNQDTNEGVEKIEPIPSIRASQLSQQVKSSFEKSASHQQHKTPLSTGPLRLEHNMSNQPSNINEMAREMDTLLQSIEGPGGFKDSCAFILKSNVEELEQGLESLAGKCQTWKSTIHEQQAEIQHLLDKTIQVLAKKTYMEGMYKQTADNQYWQLWNRQKLNPELEAKRQHIMKLNKDLTHQLIELERYFNRLELDRYNEDGGHPVARRGVPNRSAPSRRVQSLHSLHNTMSSQLAAAEQLSECLSKQMTYLKIDSPVKKNVKQELFETIGIPYDASFSSPDAVKAKNASSAKNLLLSSIPASINQQSRQRQSSAMKNSDPETARRRRESLDRVIFNWAAFEPPKTTVKRMLLQEQQKTGMNQQTVLSERLRSANNTQDRSLLHVKDHASPVVSSNKGIMESFQQDTSEAQSTPFKTRPPMPQSNSPFTISPISASKPSFNWSGNKSSNTTSYAEESAPSQIKDTRTVSQPGGSSFLPKRPVASTVLEQTEKKAGEFKFSEAKANAFVETAAGSVQRLSTTSSGSDFESSKGFGAQFSTMSSGAPASSFSSKSLFGFNSSSSIPGDKFTFPAVTAPLSGTPLDSTSTLFTASSAPVSSSSQDPVPASIPISSAPVPQTFSVTSTSTVSATGFNVPFGKPLTSVKVDLNQAAPSTPSPSPGPTAGFTFNLPALSPSSPEMVSSSTGQSSLFPPSAPTSQVSSDQASATSSLTDSSRLFSSTSLSSTPPITPPDAFQSPQVSTPSSAVPITEPVSEPKKPEAQSSSILSTQSTVDSVANATKTQNEPLPVKSEISNPGTTVTPVSSSGFLSGFSSGTQSSLASMAAPSFSWPGSSQPQQLSSTPAPFPASSPTSASPFGEKKDIVDTQEDEMDEEAPEASQTTELSMGSFGGFGLGSTPNPGAPKTNPFGGPFGNATTTTSNPFNMTVPSGELFKPASFNFQNPQPSQPAGFGSFSVTPSQTPAQSGFGQPSQIGGGQQALGSVLGSFGQSRQIGAGLPGATFGSPTGFGGSNPGSGLPNAPASGGFAAAGSSATGGFAAMASAGRGFAGASSTPTGGFAALASGSGGFAGAAPGGGGGGFGGLGSGTGGFGGFAPQGSSGGFAGAAGGGGFGGFGGQAQGQAGGGGFSAFG | ||||||
Repeat | 550-551 | 2 | ||||
Sequence: FG | ||||||
Repeat | 586-587 | 3 | ||||
Sequence: FG | ||||||
Compositional bias | 594-615 | Polar residues | ||||
Sequence: AILQSPQNTSSQPWSSGKSVSP | ||||||
Region | 594-646 | Disordered | ||||
Sequence: AILQSPQNTSSQPWSSGKSVSPPDFVSGPFPSMRDTQHKQSVQSGTGYVNPPM | ||||||
Compositional bias | 626-643 | Polar residues | ||||
Sequence: MRDTQHKQSVQSGTGYVN | ||||||
Region | 693-724 | Disordered | ||||
Sequence: SQLSQQVKSSFEKSASHQQHKTPLSTGPLRLE | ||||||
Coiled coil | 839-868 | |||||
Sequence: KRQHIMKLNKDLTHQLIELERYFNRLELDR | ||||||
Compositional bias | 974-990 | Polar residues | ||||
Sequence: SINQQSRQRQSSAMKNS | ||||||
Region | 974-999 | Disordered | ||||
Sequence: SINQQSRQRQSSAMKNSDPETARRRR | ||||||
Compositional bias | 1073-1145 | Polar residues | ||||
Sequence: SFQQDTSEAQSTPFKTRPPMPQSNSPFTISPISASKPSFNWSGNKSSNTTSYAEESAPSQIKDTRTVSQPGGS | ||||||
Region | 1073-1154 | Disordered | ||||
Sequence: SFQQDTSEAQSTPFKTRPPMPQSNSPFTISPISASKPSFNWSGNKSSNTTSYAEESAPSQIKDTRTVSQPGGSSFLPKRPVA | ||||||
Repeat | 1204-1205 | 4 | ||||
Sequence: FG | ||||||
Repeat | 1226-1227 | 5 | ||||
Sequence: FG | ||||||
Repeat | 1307-1308 | 6 | ||||
Sequence: FG | ||||||
Region | 1319-1472 | Disordered | ||||
Sequence: NQAAPSTPSPSPGPTAGFTFNLPALSPSSPEMVSSSTGQSSLFPPSAPTSQVSSDQASATSSLTDSSRLFSSTSLSSTPPITPPDAFQSPQVSTPSSAVPITEPVSEPKKPEAQSSSILSTQSTVDSVANATKTQNEPLPVKSEISNPGTTVTP | ||||||
Compositional bias | 1331-1419 | Polar residues | ||||
Sequence: GPTAGFTFNLPALSPSSPEMVSSSTGQSSLFPPSAPTSQVSSDQASATSSLTDSSRLFSSTSLSSTPPITPPDAFQSPQVSTPSSAVPI | ||||||
Compositional bias | 1427-1472 | Polar residues | ||||
Sequence: KKPEAQSSSILSTQSTVDSVANATKTQNEPLPVKSEISNPGTTVTP | ||||||
Compositional bias | 1494-1526 | Polar residues | ||||
Sequence: AAPSFSWPGSSQPQQLSSTPAPFPASSPTSASP | ||||||
Region | 1494-1577 | Disordered | ||||
Sequence: AAPSFSWPGSSQPQQLSSTPAPFPASSPTSASPFGEKKDIVDTQEDEMDEEAPEASQTTELSMGSFGGFGLGSTPNPGAPKTNP | ||||||
Repeat | 1527-1528 | 7 | ||||
Sequence: FG | ||||||
Repeat | 1559-1560 | 8 | ||||
Sequence: FG | ||||||
Repeat | 1562-1563 | 9 | ||||
Sequence: FG | ||||||
Repeat | 1578-1579 | 10 | ||||
Sequence: FG | ||||||
Repeat | 1582-1583 | 11 | ||||
Sequence: FG | ||||||
Region | 1612-1643 | Disordered | ||||
Sequence: NPQPSQPAGFGSFSVTPSQTPAQSGFGQPSQI | ||||||
Repeat | 1621-1622 | 12 | ||||
Sequence: FG | ||||||
Repeat | 1637-1638 | 13 | ||||
Sequence: FG | ||||||
Repeat | 1657-1658 | 14 | ||||
Sequence: FG | ||||||
Repeat | 1672-1673 | 15 | ||||
Sequence: FG | ||||||
Repeat | 1678-1679 | 16 | ||||
Sequence: FG | ||||||
Repeat | 1750-1751 | 17 | ||||
Sequence: FG | ||||||
Repeat | 1760-1761 | 18 | ||||
Sequence: FG | ||||||
Repeat | 1781-1782 | 19 | ||||
Sequence: FG | ||||||
Repeat | 1784-1785 | 20 | ||||
Sequence: FG | ||||||
Region | 1795-1819 | Disordered | ||||
Sequence: GGFSAFGGNSGATGKPSELFTQMRK | ||||||
Repeat | 1800-1801 | 21 | ||||
Sequence: FG | ||||||
Compositional bias | 1804-1819 | Polar residues | ||||
Sequence: SGATGKPSELFTQMRK |
Domain
Contains FG repeats mediating the translocation through the NPC by interacting with transport factors.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
F4I1T7-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length1,819
- Mass (Da)192,930
- Last updated2011-06-28 v1
- Checksum2F5771A153DB287B
F4I1T7-2
- Name2
- Differences from canonical
- 1005-1007: Missing
Sequence caution
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 594-615 | Polar residues | ||||
Sequence: AILQSPQNTSSQPWSSGKSVSP | ||||||
Compositional bias | 626-643 | Polar residues | ||||
Sequence: MRDTQHKQSVQSGTGYVN | ||||||
Compositional bias | 974-990 | Polar residues | ||||
Sequence: SINQQSRQRQSSAMKNS | ||||||
Alternative sequence | VSP_057126 | 1005-1007 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 1073-1145 | Polar residues | ||||
Sequence: SFQQDTSEAQSTPFKTRPPMPQSNSPFTISPISASKPSFNWSGNKSSNTTSYAEESAPSQIKDTRTVSQPGGS | ||||||
Compositional bias | 1331-1419 | Polar residues | ||||
Sequence: GPTAGFTFNLPALSPSSPEMVSSSTGQSSLFPPSAPTSQVSSDQASATSSLTDSSRLFSSTSLSSTPPITPPDAFQSPQVSTPSSAVPI | ||||||
Compositional bias | 1427-1472 | Polar residues | ||||
Sequence: KKPEAQSSSILSTQSTVDSVANATKTQNEPLPVKSEISNPGTTVTP | ||||||
Compositional bias | 1494-1526 | Polar residues | ||||
Sequence: AAPSFSWPGSSQPQQLSSTPAPFPASSPTSASP | ||||||
Compositional bias | 1804-1819 | Polar residues | ||||
Sequence: SGATGKPSELFTQMRK |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC005223 EMBL· GenBank· DDBJ | AAD10642.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002684 EMBL· GenBank· DDBJ | AEE33262.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002684 EMBL· GenBank· DDBJ | AEE33263.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY035068 EMBL· GenBank· DDBJ | AAK59573.2 EMBL· GenBank· DDBJ | mRNA |