F4I116 · SYLC_ARATH
- ProteinLeucine--tRNA ligase, cytoplasmic
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1091 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
Catalytic activity
- ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | chloroplast | |
Cellular Component | cytosol | |
Cellular Component | plasmodesma | |
Molecular Function | aminoacyl-tRNA editing activity | |
Molecular Function | ATP binding | |
Molecular Function | leucine-tRNA ligase activity | |
Biological Process | leucyl-tRNA aminoacylation | |
Biological Process | post-embryonic development | |
Biological Process | reproductive structure development |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLeucine--tRNA ligase, cytoplasmic
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionF4I116
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000433547 | 1-1091 | Leucine--tRNA ligase, cytoplasmic | |||
Sequence: MASESKSYARRDRLLEIEATVRKWWEDEDVFRAESCENLPKPGEKFFSTFPFPYMNGYLHIGHAFSLSKVDFASAYHRLRGANVLLPFGFHCTGMPIKASADKLRREIEQFGNPPVFTAEDTTKVPEVQEESSDTIALPIPGQFKGKKSKVAAKAGGQVYQWEIMRSFGLTDSEIANFREPSEWLYYFPPLAVEDLRAYGLGCDWRRSFVTTDVNPFFDAFVRWQMRKLKSMGKIVKDRRYTIFSPLDGQPCADHDRATGEGVQPQEYTLIKMEVVKPFPLKLGPLEGKRVFLAAATLRPETMYGQTNAWVLPDGKYGAYEISETEVFILTERAALNLAYQNFSKNPQEPSCLVELTGYDLIGLPLRSPLSVNEIIYALPMLTILTNKGTGIVTSVPSDAPDDYMALQDLIKKPALQDKYGVKTEWLPTEIIPIINIPEFGDKAAEKVCLDLKIKSQNDKEKLAEAKRLTYLKGFTEGTMLIGEFFGRKVQEIKPIIKTKLIETGEAIIYSEPEKPVMSRSGDECVVALTDQWYITYGESEWRKIAEECLSKMNLYSDETRHGFEHTLSWLNQWACSRSFGLGTRIPWDEQFLVESLSDSSLYMAYYTVAHIFHDGDMYKGSKSLIRPQQMNDEVWEYLFCDGPYPKSSDIPSAVLSEMKQEFDYWYPLDLRVSGKDLIQNHLTFFIYNHTALMANRNWPRGIRCNGHIMLNSEKMSKSTGNFRTLRQSIEEFSATGTRFCLADAGDGVDDANFAFETANAAILRLTKELTWMEEVLDVESSLRTGPPSTYADKVFENDMNIALRLTERAYKDCLFREALKNGFYDLQAARDEYRLSCGTGGMHHDLLLKFMDVQTRLIVPICPHFADYVWRKVLNKEGCVLTAGWPPSNEPDLVLKSANKYLQDSIVLMRKLLQKQLSGSKKGAKKGAQVTAVPEGKLKGLVYVNEQFDGWRAHCLRILQSRFDQQTCSFPPDTEMLAELSATLLQEGKNLKAIQKVCMPFLKFKKDEAISIGTQALNLRLPFGEIEVLQSNKDLIRRQLGLEEVEIYSASDPDDVSIAGPHASLLTQNPPSPGSPTAIFVTSTSVCPPS |
Proteomic databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for motif.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Motif | 53-63 | 'HIGH' region | ||||
Sequence: PYMNGYLHIGH | ||||||
Motif | 715-719 | 'KMSKS' region | ||||
Sequence: KMSKS |
Sequence similarities
Belongs to the class-I aminoacyl-tRNA synthetase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,091
- Mass (Da)123,451
- Last updated2011-06-28 v1
- Checksum7875BD1F436674CC
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 591 | in Ref. 3; BAD95115 | ||||
Sequence: Q → L |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC000132 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
AC003970 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CP002684 EMBL· GenBank· DDBJ | AEE28469.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK222125 EMBL· GenBank· DDBJ | BAD95115.1 EMBL· GenBank· DDBJ | mRNA |