F4HWY6 · MYO11_ARATH
- ProteinMyosin-11
- GeneXI-E
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1529 (go to sequence)
- Protein existenceInferred from homology
- Annotation score5/5
Function
function
Myosin heavy chain that is required for the cell cycle-regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Involved in trafficking of Golgi stacks, mitochondria and peroxisomes.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | myosin complex | |
Molecular Function | actin binding | |
Molecular Function | ATP binding | |
Molecular Function | calmodulin binding | |
Molecular Function | cytoskeletal motor activity | |
Molecular Function | microfilament motor activity | |
Biological Process | actin filament organization | |
Biological Process | actin filament-based movement | |
Biological Process | organelle localization | |
Biological Process | pollen tube growth |
Keywords
- Molecular function
- Ligand
Names & Taxonomy
Protein names
- Recommended nameMyosin-11
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionF4HWY6
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with peroxisome, cytoplasmic vesicles and/or organelles.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000422866 | 1-1529 | Myosin-11 | |||
Sequence: MRNSGTPVNIIVGSHVWIEDSDVAWIDGLVEKINGQDVEVQATNGKKITAKLSKIYPKDMEAPAGGVDDMTKLSYLHEPGVLQNLKIRYELNEIYTYTGNILIAINPFQRLPHIYDAHMMQQYKGAPFGELSPHVFAVADVAYRAMINEGKSNSILVSGESGAGKTETTKMLMRYLAYLGGRAVTEGRTVEQQVLESNPVLEAFGNAKTVRNNNSSRFGKFVEIQFDKQGRISGAAVRTYLLERSRVCQISDPERNYHCFYLLCAAPQEELEKYKLGHPKTFHYLNQSKCFELVGISDAHDYIATRRAMDIVGMSEKEQEAIFRVVAAILHLGNVEFTKGKEVDSSVPKDDKSKFHLNTVAELLMCDVKALEDALCKRVMVTPEEVIKRSLDPQSALISRDGLAKTIYSRLFDWLVEKINVSIGQDATSRSLIGVLDIYGFESFKTNSFEQFCINFTNEKLQQHFNQHVFKMEQEEYTKEAIDWSYIEFVDNQDVLDLIEKKPGGIVALLDEACMFPKSTHETFANKLYQTFKTHKRFIKPKLSRTDFAVAHYAGEVQYQSDLFLDKNKDYVIPEHQDLLGASKCPFVVGLFPPLPEETSKSSKFSSIGSRFKLQLQQLMETLNSTEPHYIRCVKPNNLLKPAVFENVNIMQQLRCGGVLEAIRISCAGYPTRKPFFEFINRFGLLYPRALEGNYEEKAAAQKILDNIGLKGYQVGKTKVFLRAGQMAELDARRTMVLSAAAKKIQRRIRTHQAQRRFILLRKATISLQALCRGRLSSKIFDNLRRQAAAVKIQKNARRLHSRKSYKNLHVAALVVQTGLRAMAAHKQFRFRKQTKAATTIQAQFRCHRATLYFKKLKKGVILSQTRWRGKLARRELRQLKMASRETGALKEAKDMLEKKVEELTYRAQLEKRSRVDLEEEKNQEIKKLQSSLEEMRKKVDETNGLLVKEREAAKKAIEEAPPVVTETQVLVEDTQKIEALTEEVEGLKANLEQEKQRADDATRKFDEAQESSEDRKKKLEDTEKKAQQLQESVTRLEEKCNNLESENKVLRQQAVSIAPNKFLSGRSRSILQRGSESGHLSVDARPSLDLHSHSINRRDLSEVDDKPQKSLNEKQQENQELLIRCIVQHLGFQGKRPVTACIIYKCLLQWRSFEVERTSVFDRIIQTIGQAIETQDNNNILAYWLSNASTLLLLLQRTLKASGAAGMAPQRRRSSSATLFGRMTQSFRGTPQGVNLAMINGGVDTLRQVEAKYPALLFKQQLTAYVEKIYGMIRDNLKKEISPLLGLCIQAPRTSRASLVKGASRSVGNTAAQQALIAHWQGIVKSLTNFLNNLKSNHVPPFLVRKVFTQIFSFINVQLFNSLLLRRECCSFSNGEYVKAGLAELEHWCYNATDEYAGSSWDELKHIRQAIGFLVIHQKPKKTLDEISHELCPVLSIQQLYRISTMYWDDKYGTHSVSPDVIANMRVLMTEDSNNAVSNSFLLDDDSSIPFSVDDLSKSMERIEIGDVEPPPLIRENSGFSFLLPCSD |
Proteomic databases
PTM databases
Expression
Gene expression databases
Interaction
Structure
Family & Domains
Features
Showing features for domain, region, coiled coil, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 11-60 | Myosin N-terminal SH3-like | ||||
Sequence: IVGSHVWIEDSDVAWIDGLVEKINGQDVEVQATNGKKITAKLSKIYPKDM | ||||||
Domain | 65-735 | Myosin motor | ||||
Sequence: GGVDDMTKLSYLHEPGVLQNLKIRYELNEIYTYTGNILIAINPFQRLPHIYDAHMMQQYKGAPFGELSPHVFAVADVAYRAMINEGKSNSILVSGESGAGKTETTKMLMRYLAYLGGRAVTEGRTVEQQVLESNPVLEAFGNAKTVRNNNSSRFGKFVEIQFDKQGRISGAAVRTYLLERSRVCQISDPERNYHCFYLLCAAPQEELEKYKLGHPKTFHYLNQSKCFELVGISDAHDYIATRRAMDIVGMSEKEQEAIFRVVAAILHLGNVEFTKGKEVDSSVPKDDKSKFHLNTVAELLMCDVKALEDALCKRVMVTPEEVIKRSLDPQSALISRDGLAKTIYSRLFDWLVEKINVSIGQDATSRSLIGVLDIYGFESFKTNSFEQFCINFTNEKLQQHFNQHVFKMEQEEYTKEAIDWSYIEFVDNQDVLDLIEKKPGGIVALLDEACMFPKSTHETFANKLYQTFKTHKRFIKPKLSRTDFAVAHYAGEVQYQSDLFLDKNKDYVIPEHQDLLGASKCPFVVGLFPPLPEETSKSSKFSSIGSRFKLQLQQLMETLNSTEPHYIRCVKPNNLLKPAVFENVNIMQQLRCGGVLEAIRISCAGYPTRKPFFEFINRFGLLYPRALEGNYEEKAAAQKILDNIGLKGYQVGKTKVFLRAGQMAELDARRT | ||||||
Region | 498-532 | Actin-binding | ||||
Sequence: LIEKKPGGIVALLDEACMFPKSTHETFANKLYQTF | ||||||
Region | 534-557 | Actin-binding | ||||
Sequence: THKRFIKPKLSRTDFAVAHYAGEV | ||||||
Region | 592-616 | Actin-binding | ||||
Sequence: FPPLPEETSKSSKFSSIGSRFKLQL | ||||||
Region | 616-638 | Actin-binding | ||||
Sequence: LQQLMETLNSTEPHYIRCVKPNN | ||||||
Domain | 738-767 | IQ 1 | ||||
Sequence: LSAAAKKIQRRIRTHQAQRRFILLRKATIS | ||||||
Domain | 761-790 | IQ 2 | ||||
Sequence: LRKATISLQALCRGRLSSKIFDNLRRQAAA | ||||||
Domain | 786-815 | IQ 3 | ||||
Sequence: RQAAAVKIQKNARRLHSRKSYKNLHVAALV | ||||||
Domain | 809-838 | IQ 4 | ||||
Sequence: LHVAALVVQTGLRAMAAHKQFRFRKQTKAA | ||||||
Domain | 834-863 | IQ 5 | ||||
Sequence: QTKAATTIQAQFRCHRATLYFKKLKKGVIL | ||||||
Domain | 857-886 | IQ 6 | ||||
Sequence: LKKGVILSQTRWRGKLARRELRQLKMASRE | ||||||
Coiled coil | 887-1059 | |||||
Sequence: TGALKEAKDMLEKKVEELTYRAQLEKRSRVDLEEEKNQEIKKLQSSLEEMRKKVDETNGLLVKEREAAKKAIEEAPPVVTETQVLVEDTQKIEALTEEVEGLKANLEQEKQRADDATRKFDEAQESSEDRKKKLEDTEKKAQQLQESVTRLEEKCNNLESENKVLRQQAVSIA | ||||||
Region | 993-1031 | Disordered | ||||
Sequence: EQEKQRADDATRKFDEAQESSEDRKKKLEDTEKKAQQLQ | ||||||
Compositional bias | 1096-1114 | Basic and acidic residues | ||||
Sequence: INRRDLSEVDDKPQKSLNE | ||||||
Region | 1096-1115 | Disordered | ||||
Sequence: INRRDLSEVDDKPQKSLNEK | ||||||
Domain | 1163-1472 | Dilute | ||||
Sequence: DRIIQTIGQAIETQDNNNILAYWLSNASTLLLLLQRTLKASGAAGMAPQRRRSSSATLFGRMTQSFRGTPQGVNLAMINGGVDTLRQVEAKYPALLFKQQLTAYVEKIYGMIRDNLKKEISPLLGLCIQAPRTSRASLVKGASRSVGNTAAQQALIAHWQGIVKSLTNFLNNLKSNHVPPFLVRKVFTQIFSFINVQLFNSLLLRRECCSFSNGEYVKAGLAELEHWCYNATDEYAGSSWDELKHIRQAIGFLVIHQKPKKTLDEISHELCPVLSIQQLYRISTMYWDDKYGTHSVSPDVIANMRVLMTE |
Domain
IQ domain mediates interaction with calmodulin.
The tail domain is a globular cargo-binding domain.
Sequence similarities
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Plant myosin class XI subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,529
- Mass (Da)173,610
- Last updated2011-06-28 v1
- Checksum1176797078E8193B
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A178WJA4 | A0A178WJA4_ARATH | XIE | 1526 |
Sequence caution
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 1096-1114 | Basic and acidic residues | ||||
Sequence: INRRDLSEVDDKPQKSLNE |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AC005388 EMBL· GenBank· DDBJ | AAC64896.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
CP002684 EMBL· GenBank· DDBJ | AEE33118.1 EMBL· GenBank· DDBJ | Genomic DNA |