F3YC44 · F3YC44_MELPT
- ProteinUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
- GenemurF
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids461 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.
Catalytic activity
- UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine + ATP = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP + phosphate + H+
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | ATP binding | |
Molecular Function | UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity | |
Molecular Function | UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity | |
Biological Process | cell division | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Enterococcaceae > Melissococcus
Accessions
- Primary accessionF3YC44
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 26-95 | Mur ligase N-terminal catalytic | ||||
Sequence: INTIEFDSRQLASGSLFIPLGGKTDGHQFIMDARSQGAKAALWSKESSLAPEGFPILEVVDTLKAIQDLA | ||||||
Domain | 109-292 | Mur ligase central | ||||
Sequence: VTGSNGKTTTKDMIAAVLAKKYITYKTQGNYNNQIGLPYTILHMPEETEMLVLEMGMDHADEIDFLSQLASPTVAAITMIGEAHIENLGSRQEIAKAKMGITKGLVEDGLLIIPENEPLLKPLTANSTQTIKTFGFTNEADFVECVQLEEKNKTTFKLSGYQLPFTIPVPGKYNVDNACIALII | ||||||
Domain | 316-441 | Mur ligase C-terminal | ||||
Sequence: RTEWVTANNGVEILSDVYNANPTAVSLVLDSFGQMFTNGRRIVVLGDMLELGATSKMMHQQLSKHLFPAIIQEVFLYGTEMKNLFLILEKTYGNHVHYYPKMEKEHLIVYLKATLQPNDLLLVKGS |
Sequence similarities
Belongs to the MurCDEF family. MurF subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length461
- Mass (Da)51,534
- Last updated2011-06-28 v1
- Checksum118FE7E735368144
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP012200 EMBL· GenBank· DDBJ | BAK22072.1 EMBL· GenBank· DDBJ | Genomic DNA |