F3YAS9 · F3YAS9_MELPT

Function

function

Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD+.

Cofactor

Protein has several cofactor binding sites:
FAD (UniProtKB | Rhea| CHEBI:57692 )

Note: Binds 1 FAD per subunit.
[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Note: Binds 1 [2Fe-2S] cluster per subunit.
[2Fe-2S] cluster (UniProtKB | Rhea| CHEBI:190135 )

Note: Binds 1 [2Fe-2S] cluster per subunit.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD+ route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site51-54FAD (UniProtKB | ChEBI)
Binding site68-70FAD (UniProtKB | ChEBI)
Binding site75-76FAD (UniProtKB | ChEBI)
Binding site222[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site227[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site230[2Fe-2S] cluster (UniProtKB | ChEBI)
Binding site247[2Fe-2S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function2 iron, 2 sulfur cluster binding
Molecular Functionelectron transfer activity
Molecular Functionflavin adenine dinucleotide binding
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity
Biological Process'de novo' UMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit
  • Alternative names
    • Dihydroorotate oxidase B, electron transfer subunit

Gene names

    • Name
      pyrK
    • Ordered locus names
      MPTP_1156

Organism names

Accessions

  • Primary accession
    F3YAS9

Proteomes

Interaction

Subunit

Heterotetramer of 2 PyrK and 2 PyrD type B subunits.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-100FAD-binding FR-type

Sequence similarities

Belongs to the PyrK family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    260
  • Mass (Da)
    28,351
  • Last updated
    2011-06-28 v1
  • Checksum
    6E9E19309EDF687C
MKQEQMTVVLQKQLAPHIYQMTLTGELVKEMNMPGQFLHIKVPKADLLLRRPISLNQIDHEKNTCTIIYRTEGTGTKILSTLNADDKLDVMGPLGNGFKIDGVNSGQIAFIVGGGIGIPPLYELSKQLTKRGVHVVHFLGYATKELIYFKEEFMNLGETQFATDDGTYGVEGNVGNLLAEASQTMFPDAIYACGPNGMLKTIVQLFSTLSNIFLSLEERMACGIGACNACVCPVQGDKTGTRSVKVCEDGPVFLANEVVL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP012200
EMBL· GenBank· DDBJ
BAK21607.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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