F3YAF8 · F3YAF8_MELPT

Function

function

DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site189[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site196[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site199[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site205[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionclass I DNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular FunctionDNA binding
Molecular FunctionDNA N-glycosylase activity
Molecular Functionendonuclease activity
Molecular Functionmetal ion binding
Biological Processbase-excision repair, AP site formation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease III
  • EC number
  • Alternative names
    • DNA-(apurinic or apyrimidinic site) lyase

Gene names

    • Name
      nth
    • Ordered locus names
      MPTP_1028

Organism names

Accessions

  • Primary accession
    F3YAF8

Proteomes

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain39-187HhH-GPD

Sequence similarities

Belongs to the Nth/MutY family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    217
  • Mass (Da)
    24,591
  • Last updated
    2011-06-28 v1
  • Checksum
    7FA1DDE128043725
MLSKEKTMEAINIMYEMFPNAKGELNRKNPFEYLIAVSLSAQTTDVSVNKVTPALFAAYPTPEALANAPIEAIIEKIKTIGLYRNKAKNIKACAEQLVERFDSQVPQTHKELMSLPGVGQKTANVVMADMFNEPSLAVDTHVERVSKRLRFCSLKANVSQVEETLKKKVPKHLWIKTHHTLIFFGRYHCFARNPKCPVCPLLYMCPEGKKRLKVKND

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP012200
EMBL· GenBank· DDBJ
BAK21486.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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