F3YAD0 · F3YAD0_MELPT

Function

function

The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity but not helicase activity.

Miscellaneous

Despite having helicase-like domains, this subunit does not have helicase activity.

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site820[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site1150[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site1156[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Function5'-3' exonuclease activity
Molecular FunctionATP binding
Molecular Functiondouble-stranded DNA binding
Molecular Functionhelicase activity
Molecular Functionhydrolase activity, acting on acid anhydrides
Molecular Functionmetal ion binding
Biological Processdouble-strand break repair via homologous recombination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent helicase/deoxyribonuclease subunit B
  • EC number
  • Alternative names
    • ATP-dependent helicase/nuclease subunit RexB

Gene names

    • Name
      rexB
    • Ordered locus names
      MPTP_0999

Organism names

Accessions

  • Primary accession
    F3YAD0

Proteomes

Interaction

Subunit

Heterodimer of AddA and RexB.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-282ATP-dependent helicase/deoxyribonuclease subunit B N-terminal
Domain809-1156PD-(D/E)XK endonuclease-like

Sequence similarities

Belongs to the helicase family. AddB/RexB type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,202
  • Mass (Da)
    140,130
  • Last updated
    2011-06-28 v1
  • Checksum
    D927F0ABA59E4E5B
MSLQFIRGKMTADLEEPLIQQAVNWLDQSANHEVFYLVPRHIEFEKEIDVLKKIRQMNRDTMIASTRLQIFNFDRLAWYYLRDTSYYSSKLLPEAGAAMLFRQVLLENEQELQIFQGEITKEGFIQQLFVFYQEIQDGNITIDELDTFLTQLDKGAKEQELQIKLKDLALIFTKFEEKAKNYQFDTKKIVENLTKYLTNQNLSHVSFLISGFHQFTAKELELICLLIKKAGEVKISLPLDRSYTNSLPEPMDIFAETGTLYYQFYQFARTNRVPLFTDYVVNESSLIPTTGICQLENYWIAAQKQYFPKMQQQILDNCVQIWKGENVKEEILSVACEIRRLVAEEGYRYKDIQLITRDMACYENLLKPLLALYDIPIYLDHDQTMEQHPLVEWIQSFFAIYNYNYRYRDILRFLRTELFFPKENQKWETIEQWQAACREWRNKVDITENVVLAYGYEGTYWSRKQDWSFIQYDFEEHKLENTKQIEEDSNEIRQKVQKYLPVCFKKLKKAKNGLEAAKIFHHFLIESGVKYQMNQWRIQAIEAGNLEEAKNHEQVWTALMTLLDEYVEIYKNEPFFFETFQEIFTSGLAGINYSRIPATIDQVQVRLIDLTRAAAAKVIFAIGLTEEAFPKKIENKTLLSDEERQLIDLYLADDQFLANSTEKKIAQEPFIAYKMLVSATEKLYLTYHCTKDTKQEIKCSPYIRNIQQAFMLPIIEKREGLPTDDEAISLTHIGTYPALIGELTRLKRQNQEIGEPVSGFWLAMEKALTRQPEISQTASFVFSSLGYTNNPENLTETFAEALYGKHIYTSISQMEAFHHCQFQYFLQFGLNLKERLLFQLTSAATGEFFHEALDQFFKLLIRQNKYLPDLTDEEVANFSDNVLTAVLDEPKFSILTSSNRMNYLRYQLSQTIKKVSWALKKQSQKSGFSTVQTEILFGQLAIQQGIPGLELALEKQGKISVRGKIDRVDQLITNDHEVYLGVIDYKSSHRKFNITEVYYGLAMQMLTYLDVALMDAVQLVGKTAKPAGSFYLHVHNPTLSYDTTGAIEQKLLKKYQYDGLLINDSELLNYLDKELEEKTSSTIFPIEASAKGIIKPGRKQENKFVTEMELQSLLKNNREKIKKAGNKIINGEIQMNPAYQGKERIACRFCQFKSICTFDTMLKENNYHKIATLSKKEVMERLSKEGIECIDDGKKDSITTTK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP012200
EMBL· GenBank· DDBJ
BAK21458.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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