F3YAD0 · F3YAD0_MELPT
- ProteinATP-dependent helicase/deoxyribonuclease subunit B
- GenerexB
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1202 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. This subunit has 5' -> 3' nuclease activity but not helicase activity.
Miscellaneous
Despite having helicase-like domains, this subunit does not have helicase activity.
Cofactor
Protein has several cofactor binding sites:
Note: Binds 1 [4Fe-4S] cluster.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | 5'-3' exonuclease activity | |
Molecular Function | ATP binding | |
Molecular Function | double-stranded DNA binding | |
Molecular Function | helicase activity | |
Molecular Function | hydrolase activity, acting on acid anhydrides | |
Molecular Function | metal ion binding | |
Biological Process | double-strand break repair via homologous recombination |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameATP-dependent helicase/deoxyribonuclease subunit B
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Enterococcaceae > Melissococcus
Accessions
- Primary accessionF3YAD0
Proteomes
Interaction
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 5-282 | ATP-dependent helicase/deoxyribonuclease subunit B N-terminal | ||||
Sequence: FIRGKMTADLEEPLIQQAVNWLDQSANHEVFYLVPRHIEFEKEIDVLKKIRQMNRDTMIASTRLQIFNFDRLAWYYLRDTSYYSSKLLPEAGAAMLFRQVLLENEQELQIFQGEITKEGFIQQLFVFYQEIQDGNITIDELDTFLTQLDKGAKEQELQIKLKDLALIFTKFEEKAKNYQFDTKKIVENLTKYLTNQNLSHVSFLISGFHQFTAKELELICLLIKKAGEVKISLPLDRSYTNSLPEPMDIFAETGTLYYQFYQFARTNRVPLFTDYVVN | ||||||
Domain | 809-1156 | PD-(D/E)XK endonuclease-like | ||||
Sequence: TSISQMEAFHHCQFQYFLQFGLNLKERLLFQLTSAATGEFFHEALDQFFKLLIRQNKYLPDLTDEEVANFSDNVLTAVLDEPKFSILTSSNRMNYLRYQLSQTIKKVSWALKKQSQKSGFSTVQTEILFGQLAIQQGIPGLELALEKQGKISVRGKIDRVDQLITNDHEVYLGVIDYKSSHRKFNITEVYYGLAMQMLTYLDVALMDAVQLVGKTAKPAGSFYLHVHNPTLSYDTTGAIEQKLLKKYQYDGLLINDSELLNYLDKELEEKTSSTIFPIEASAKGIIKPGRKQENKFVTEMELQSLLKNNREKIKKAGNKIINGEIQMNPAYQGKERIACRFCQFKSIC |
Sequence similarities
Belongs to the helicase family. AddB/RexB type 2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,202
- Mass (Da)140,130
- Last updated2011-06-28 v1
- ChecksumD927F0ABA59E4E5B
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP012200 EMBL· GenBank· DDBJ | BAK21458.1 EMBL· GenBank· DDBJ | Genomic DNA |