F3Y9R0 · F3Y9R0_MELPT
- ProteinUDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
- GenemurG
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids361 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).
Catalytic activity
- Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + UDP-N-acetyl-alpha-D-glucosamine = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H+ + UDP
Pathway
Cell wall biogenesis; peptidoglycan biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 10-12 | UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI) | ||||
Sequence: TGG | ||||||
Binding site | 124 | UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 195 | UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 248 | UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI) | ||||
Sequence: I | ||||||
Binding site | 293 | UDP-N-acetyl-alpha-D-glucosamine (UniProtKB | ChEBI) | ||||
Sequence: Q |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity | |
Molecular Function | undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity | |
Biological Process | carbohydrate metabolic process | |
Biological Process | cell division | |
Biological Process | cell wall organization | |
Biological Process | lipid glycosylation | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Enterococcaceae > Melissococcus
Accessions
- Primary accessionF3Y9R0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-142 | Glycosyltransferase family 28 N-terminal | ||||
Sequence: VLVTGGGTGGHIYPALALIDHLKKIEPATEFLYVGSTNGLESNIVPTRGISFEQIHTQGFKRSLSIQNIKTVYLFFECIRKSKKILREFQPNIVIGTGGYVSGAVIYAAKQLKIPTIIHEQNSIPGMTNKFLSRYVDKVA | ||||||
Domain | 188-351 | Glycosyl transferase family 28 C-terminal | ||||
Sequence: TVVIFGGSRGALKINQAFVEALPLFENKPYQVLYASGERYYQETIKLVKSKLTNVSIQPYIDKMAEVMANVDLIVGRAGATSIAEITALGLPAILIPSPYVTNDHQTKNAQSLVDVGAATMITDQELSKTTLIKAIDDILLDDDKKRQMAQASKKEGIPDACNR |
Sequence similarities
Belongs to the glycosyltransferase 28 family. MurG subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length361
- Mass (Da)39,771
- Last updated2011-06-28 v1
- Checksum8A490462C23F8BF0
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP012200 EMBL· GenBank· DDBJ | BAK21238.1 EMBL· GenBank· DDBJ | Genomic DNA |