F3Y9K6 · F3Y9K6_MELPT
- ProteinRibosomal RNA small subunit methyltransferase A
- GenersmA
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids294 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
Catalytic activity
- adenosine1518/adenosine1519 in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H+ + N6-dimethyladenosine1518/N6-dimethyladenosine1519 in 16S rRNA + 4 S-adenosyl-L-homocysteine
RHEA-COMP:10232 CHEBI:74411 Position: 1518CHEBI:74411 Position: 1519+ 4 CHEBI:59789 = 4 CHEBI:15378 + RHEA-COMP:10233 CHEBI:74493 Position: 1518CHEBI:74493 Position: 1519+ 4 CHEBI:57856
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 31 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 33 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 58 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 79 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 104 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 129 | S-adenosyl-L-methionine (UniProtKB | ChEBI) | ||||
Sequence: N |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity | |
Molecular Function | 23S rRNA (adenine(2085)-N(6))-dimethyltransferase activity | |
Molecular Function | RNA binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibosomal RNA small subunit methyltransferase A
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Enterococcaceae > Melissococcus
Accessions
- Primary accessionF3Y9K6
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 38-214 | Ribosomal RNA adenine methylase transferase N-terminal | ||||
Sequence: ILKKIVATANLTKEVNVIEVGPGIGALTEQLAQQAGQVLAFEIDHNLIRILADTLQPYNNITIVNQDVLKTDLVKETQAVFQQAYPIKIVANLPYYITTPILMYFLQSDLIVEEMVVMMQKEVADRISAKPGTKAYGSLSIAVQYFMEATIAFIVPKTVFVPQPNVDSAVIKLTRRS |
Sequence similarities
Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length294
- Mass (Da)33,342
- Last updated2011-06-28 v1
- Checksum9E22FF22D87211C5
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP012200 EMBL· GenBank· DDBJ | BAK21184.1 EMBL· GenBank· DDBJ | Genomic DNA |