F3Y8E0 · F3Y8E0_MELPT
- ProteinHypoxanthine phosphoribosyltransferase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids181 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.
Catalytic activity
- diphosphate + GMP = 5-phospho-alpha-D-ribose 1-diphosphate + guanineThis reaction proceeds in the backward direction.
Cofactor
Pathway
Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | guanine phosphoribosyltransferase activity | |
Molecular Function | hypoxanthine phosphoribosyltransferase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | nucleotide binding | |
Biological Process | GMP salvage | |
Biological Process | guanine salvage | |
Biological Process | hypoxanthine metabolic process | |
Biological Process | IMP salvage | |
Biological Process | purine ribonucleoside salvage |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameHypoxanthine phosphoribosyltransferase
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Enterococcaceae > Melissococcus
Accessions
- Primary accessionF3Y8E0
Proteomes
Subcellular Location
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 14-160 | Phosphoribosyltransferase | ||||
Sequence: KQIFDRTIELGRQLTEDYQDKNPLVIGILKGAVPFIADLTSQIDEKLELDFMAVSSYGNATISSGEVKIIKDLDTNVEGRHILIVEDIIDSGRTLAYLVDLFKYRKAASVKIVTLLDKPEGRVVNITADYVGFDVPDEFVVGYGMDY |
Sequence similarities
Belongs to the purine/pyrimidine phosphoribosyltransferase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length181
- Mass (Da)20,462
- Last updated2011-06-28 v1
- ChecksumCD631D24023F313C
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AP012200 EMBL· GenBank· DDBJ | BAK20768.1 EMBL· GenBank· DDBJ | Genomic DNA |