The findings strengthen the importance of NAA40 to maintain colorectal cancer cell growth. We show that NAA40 oncogenic properties stimulate the global levels of H4R3me2s by transcriptionally activating PRMT5 methyltransferase which in turn modulates the expression of key downstream cancer-related genes.
NatD-mediated acetylation of histone H4 serine 1 competes with phosphorylation by CK2alpha at the same residue leading to the upregulation of Slug and lung cancer progression.
The knowledge of detailed molecular architecture of Patt1 is not only the key to understanding its mechanistic functional properties but it also opens the possibility of rational drug and protein design experiments
Results strongly suggest that human Naa40p/NatD is conserved from yeast. Thus the NATs of all classes of N-terminally acetylated proteins in humans now appear to be accounted for.
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