F2Y991 · F2Y991_9MUSC

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    COI
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

heme (UniProtKB | Rhea| CHEBI:30413 )

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      COI

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Tephritoidea > Tephritidae > Anastrepha > Anastrepha fraterculus complex

Accessions

  • Primary accession
    F2Y991

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane65-91Helical
Transmembrane103-130Helical
Transmembrane150-174Helical

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-43
ChainPRO_500765668844-197Cytochrome c oxidase subunit 1

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-197Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    197
  • Mass (Da)
    21,348
  • Last updated
    2011-05-31 v1
  • Checksum
    BA1FE831FE2A3C31
WLVPLMLGAPDMAFPRMNNMSFWLLPPSLTLLLVSSMVENGAGTGWTVYPPLSSLIAHGGASVDLAIFSLHLAGISSILGAVNFITTVINMRSTGMTFDRMPLFVWAVVLTALLLLLSLPVLAGAITMLLTDRNLNTSFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGMISHIISQESGKKETFGSLGMIYAM

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1
Non-terminal residue197

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HQ829880
EMBL· GenBank· DDBJ
AEA07669.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829882
EMBL· GenBank· DDBJ
AEA07670.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829883
EMBL· GenBank· DDBJ
AEA07671.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829884
EMBL· GenBank· DDBJ
AEA07672.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829885
EMBL· GenBank· DDBJ
AEA07673.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829887
EMBL· GenBank· DDBJ
AEA07674.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829888
EMBL· GenBank· DDBJ
AEA07675.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829889
EMBL· GenBank· DDBJ
AEA07676.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829890
EMBL· GenBank· DDBJ
AEA07677.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829891
EMBL· GenBank· DDBJ
AEA07678.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829892
EMBL· GenBank· DDBJ
AEA07679.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829893
EMBL· GenBank· DDBJ
AEA07680.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829894
EMBL· GenBank· DDBJ
AEA07681.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829895
EMBL· GenBank· DDBJ
AEA07682.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829896
EMBL· GenBank· DDBJ
AEA07683.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829897
EMBL· GenBank· DDBJ
AEA07684.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829898
EMBL· GenBank· DDBJ
AEA07685.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829899
EMBL· GenBank· DDBJ
AEA07686.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829900
EMBL· GenBank· DDBJ
AEA07687.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829901
EMBL· GenBank· DDBJ
AEA07688.1
EMBL· GenBank· DDBJ
Genomic DNA
HQ829902
EMBL· GenBank· DDBJ
AEA07689.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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