F2XML4 · F2XML4_9PEZI
- ProteinMultifunctional tryptophan biosynthesis protein
- GeneTRPG
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids641 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.
Catalytic activity
- 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+ = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
Pathway
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.
Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 95 | Nucleophile | |||
Active site | 189 | ||||
Active site | 191 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | anthranilate synthase activity | |
Molecular Function | indole-3-glycerol-phosphate synthase activity | |
Molecular Function | phosphoribosylanthranilate isomerase activity | |
Biological Process | glutamine metabolic process | |
Biological Process | tryptophan biosynthetic process | |
Biological Process | tryptophan metabolic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMultifunctional tryptophan biosynthesis protein
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Sordariomycetes > Sordariomycetidae > Ophiostomatales > Ophiostomataceae > Leptographium
Accessions
- Primary accessionF2XML4
Subcellular Location
UniProt Annotation
GO Annotation
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Domain | 18-207 | Glutamine amidotransferase | |||
Domain | 240-312 | Indole-3-glycerol phosphate synthase | |||
Domain | 313-412 | Indole-3-glycerol phosphate synthase | |||
Domain | 490-629 | N-(5'phosphoribosyl) anthranilate isomerase (PRAI) | |||
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusFragment
- Length641
- Mass (Da)68,434
- Last updated2011-05-31 v1
- MD5 ChecksumDF3F9E740EC95ACCD68586F84E59B0CD
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 1 | ||||
Non-terminal residue | 641 | ||||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
HQ634047 EMBL· GenBank· DDBJ | AEA10207.1 EMBL· GenBank· DDBJ | Genomic DNA |